Bioadhesive for periodontal gingival and/or bone tissues
The invention is directed to an adhesive strip, particularly an adhesive strip or bandage for use in periodontal treatments. The biocompatible adhesive strip comprises a flexible barrier with a biocompatible adhesive for use in an oral environment, wherein the adhesive is in a non-tacky state when dry and becomes adherent upon contact with liquids.
1. A flexible adhesive strip comprising:
a flexible barrier material having a first side and an opposite second side, the barrier material selected from the group consisting of gelatin, collagen, polysaccharides, poly(ethylene glycol)-block-poly(epsilon-caprolactone)-block-poly(DL-lactide), PEG-PCL-P(DL) lactic acid, RGD-containing peptides (Arg-Gly-Asp) on a polyvinyl alcohol (PVA) surface, glycol-polymer matrix, heparin, alginate cross linked gels, agarose hydro-gels, carboxylated polyurethane (CPU) membrane, expanded polytetrafluoroethylene (ePTFE) membranes, and combination thereof; and
a biocompatible adhesive comprising a cyanoacrylate adhesive compatible with an aqueous oral environment, the biocompatible adhesive including a first side and an opposite second side, the first side of the biocompatible adhesive being adhered to the second side of the flexible barrier material,
wherein the first side of the flexible barrier material is uncovered and the biocompatible adhesive is in a non-tacky state when dry and becomes adherent upon contact with a liquid, and
wherein the flexible barrier material is substantially clear.
2. The flexible adhesive strip of claim 1 , further comprising a first series of perforations formed in the flexible adhesive strip extending through opposite surfaces of flexible adhesive strip and a second series of perforations formed in the flexible adhesive strip extending through the opposite surfaces of the flexible adhesive strip that is spaced apart from the first series of perforations, the first and second series of perforations being configured to facilitate tearing of the flexible adhesive strip at the site of the perforations.
3. The flexible adhesive strip of claim 1 , wherein the flexible adhesive strip comprises at least two recessed areas and protruding areas along a first edge, wherein the at least two recessed areas are configured to at least partially accept a patient's tooth and the protruding areas are configured to reside at least partially between the teeth.
4. The flexible adhesive strip of claim 1 , wherein the flexible adhesive strip comprises a first end having an enlarged surface area, a middle section having a smaller surface area and a second end having an enlarged surface area, wherein the first and second ends are configured to be connected to tissue in the mouth of a patient on either side of a tooth line and the middle section is configured to cover an area between two non-adjacent teeth.
5. The flexible adhesive strip of claim 1 , wherein the barrier material comprises an expanded polytetrafluoroethylene (ePTFE) membrane.
6. The flexible adhesive strip of claim 1 , wherein the biocompatible adhesive further comprises a fibrin glue, a denture adhesive or a combination thereof.
7. The flexible adhesive strip of claim 1 , wherein the cyanoacrylate adhesive comprises an octyl ester cyanoacrylate adhesive.
8. The flexible adhesive strip of claim 1 , further comprising a therapeutic agent in combination with the biocompatible adhesive.
9. The flexible adhesive strip of claim 8 , wherein the therapeutic agent comprises a growth factor or an antibiotic.
10. The flexible adhesive strip of claim 9 , wherein the therapeutic agent comprises a growth factor selected from the group consisting of OP-1, BMP-2, GDF-5, PDGF, βFGF, TGF-β and combinations thereof.
11. The flexible adhesive strip of claim 9 , wherein the therapeutic agent comprises chlorohexidine.
12. The flexible adhesive strip of claim 7 , further comprising chlorohexidine.
13. The flexible adhesive strip of claim 8 , wherein the therapeutic agent is an analgesic.
14. A periodontal treatment kit, comprising:
at least one flexible adhesive strip of claim 1 ; and
a surgical jelly compatible with the barrier material of the adhesive strip.
15. The periodontal treatment kit of claim 14 , wherein the biocompatible adhesive comprises cyanoacrylate adhesive, a fibrin glue, a denture adhesive or combinations thereof.
16. The flexible adhesive strip of claim 1 , wherein the flexible barrier material has a thickness of less than 1 mm and the biocompatible adhesive has a thickness of less than 1 mm.
17. The flexible adhesive strip of claim 1 , wherein the biocompatible adhesive comprises calcium sulfate, zinc sulfate, zinc oxide, dimethoxy tetraethylenglycol, or ascorbic acid.
18. The flexible adhesive strip of claim 16 , wherein the biocompatible adhesive comprises calcium sulfate, zinc sulfate, zinc oxide, dimethoxy tetraethylenglycol, or ascorbic acid.