IP Library › Granted Patent US 8,343,463
Granted Patent B2
US 8,343,463 · App. 12/848,911 · Granted Jan 1, 2013

Optical imaging agent

Assignee: Numira Biosciences Inc.
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Quick Facts
Patent No.
US 8,343,463
App. No.
12/848,911
Granted
Jan 1, 2013
Kind
B2
Abstract

The near-infrared wavelengths (700 nm-900 nm) are a suitable optical window for light penetration and deep tissue imaging. The present invention provides a near-infrared fluorescent blood pool contrast agent. The agent is of use to detect and quantify pathological capillary leak in live animals, e.g., serially imaging of traumatized tissue (muscle) as well as tumors.

Claims (6)

1. A compound having the formula:

in which

X is a member selected from —CH 3 , —COOH, and —SO 3 H

a, b, c, and d are independently selected integers from 1 to 10; and

CD is cyclodextrin.

2. A pharmaceutical formulation comprising the compound according to claim 1 and a pharmaceutically acceptable carrier.

Assignments (5)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 16, 2015
From: NUMIRA INC; CASTELLA KIRSH V, L.P.
To: INVICRO, LLC.
Reel/Frame 035428/0193 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 4, 2014
From: NUMIRA BIOSCIENCES, INC.
To: NUMIRA, INC.
Reel/Frame 033030/0458 →
RELEASE Recorded Sep 24, 2012
From: SILICON VALLEY BANK
To: NUMIRA BIOSCIENCES, INC.
Reel/Frame 029059/0182 →
SECURITY AGREEMENT Recorded Jun 15, 2011
From: NUMIRA BIOSCIENCES, INC.
To: SILICON VALLEY BANK
Reel/Frame 026461/0757 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 30, 2010
From: DOW, KAREN B.
To: NUMIRA BIOSCIENCES INC.
Reel/Frame 024911/0918 →
Continuity (2)
Provisional Application 61230574 · Jul 31, 2009
Related Publication 20110027191A1 · Feb 3, 2011