IP Library › Granted Patent US 8,507,648
Granted Patent B2
US 8,507,648 · App. 12/850,499 · Granted Aug 13, 2013

Detection of truncation mutations by mass spectrometry

Inventors: Alex Garvin (Durmenach, FR); Sadanand Gite (Cambridge, MA); Vladislav B. Bergo (Boston, MA); Kenneth J. Rothschild (Newton, MA)
Assignee: Ambergen, Inc.
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Quick Facts
Patent No.
US 8,507,648
App. No.
12/850,499
Granted
Aug 13, 2013
Kind
B2
Abstract

This invention relates to the detection and analysis by mass spec of nascent proteins, and in particular truncated proteins, translated within cellular or cell-free translation systems. N-terminal and C-terminal epitopes introduced into these nascent proteins permit rapid and efficient isolation, as well as mass difference.

Claims (2)

1. An isolated protease-sensitive peptide having the sequence of SEQ ID NO: 7.

2. A kit for a mass spec-based protease detection assay, wherein said kit comprises the protease-sensitive peptide of claim 1 .

Assignments (1)
CONFIRMATORY LICENSE Recorded Jun 19, 2012
From: AMBERGEN INCORPORATED
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 028398/0174 →
Continuity (2)
Continuation 10903612 · Jul 30, 2004
Related Publication 20110015369A1 · Jan 20, 2011