Combination Therapy For Modulating The Human Sexual Response
The invention is directed to compositions and methods for modulating the human sexual response. The compositions comprise two or more pharmaceutically active agents which preferably include an alpha-adrenergic antagonist and a phosphodiesterase inhibitor.
1 . A method for treating male impotence comprising administering to the gastrointestinal tract of a subject, a tablet or capsule comprising an alpha-adrenergic antagonist and a dopaminergic agonist and having a disintegration time of less than about twenty minutes, wherein the dopaminergic agonist is apomorphine and the alpha-adrenergic antagonist is selected from the group consisting of phentolamine, phentolamine hydrochloride and phentolamine mesylate.
2 . The method of claim 1 , wherein the tablet or capsule comprises from about 5 mg to about 100 mg phentolamine.
3 . The method of claim 2 , wherein the tablet or capsule comprises about 20 mg phentolamine.
4 . The method of claim 2 , wherein the tablet or capsule comprises about 40 mg phentolamine.
5 . The method of claim 2 , wherein the tablet or capsule comprises about 60 mg phentolamine.
6 . The method of claim 1 , wherein the tablet or capsule has a disintegration time of less than about ten minutes.
7 . The method of claim 1 , wherein the tablet or capsule has a disintegration time of less than about one minute.
8 . The method of claim 1 , wherein the tablet or capsule is effective to improve sexual responsiveness in from about 1 minute to about 60 minutes following administration.
9 . The method of claim 1 , wherein the tablet or capsule comprises apomorphine and from about 5 mg to about 100 mg phentolamine mesylate and has a disintegration time of less than about twenty minutes.
10 . The method of claim 9 , wherein the tablet or capsule has a disintegration time of less than about ten minutes.
11 . The method of claim 10 , wherein the tablet or capsule has a disintegration time of less than about one minute.
12 . The method of claim 9 , wherein the tablet or capsule is effective to improve sexual responsiveness in from about 1 minute to about 60 minutes following administration.
13 . The method of claim 1 , wherein the tablet or capsule comprises apomorphine and about 40 mg phentolamine mesylate and has a disintegration time of less than about twenty minutes.
14 . The method of claim 13 , wherein the tablet or capsule has a disintegration time of less than about ten minutes.
15 . The method of claim 13 , wherein the tablet or capsule has a disintegration time of less than about one minute.
16 . The method of claim 13 , wherein the tablet or capsule is effective to improve sexual responsiveness in from about 1 minute to about 60 minutes following administration.