Multi-sample scattering measurements
In one general aspect, a multi-sample liquid scattering measurement apparatus is disclosed. It includes a coherent light source having an optical output axis, with sample cells that each include a volume that intersects with the optical output axis. Detectors are each positioned to detect scattered light resulting from an interaction between light from the coherent light source and one of the cells. Light scattering analysis logic is responsive to the detectors and operative to determine a property of a liquid sample in each of the sample cells based on the detected scattered light.
1. A multi-sample liquid scattering measurement apparatus, including:
a coherent light source having an optical output axis,
a plurality of walls that define a plurality of sample cells that each include a sample volume to hold one of the samples in place and wherein the optical output axis of the coherent light source passes through at least some of the walls to intersect with the sample volumes,
a plurality of detectors each positioned to detect scattered light resulting from an interaction between light from the coherent light source and a sample held in the sample volume in one of the plurality of cells, and
light scattering analysis logic responsive to the detectors and operative to determine a property of a liquid sample in each of the sample cells based on amounts of the detected scattered light detected by the detectors.
2. The apparatus of claim 1 wherein the sample cells are part of a linear array of sample cells.
3. The apparatus of claim 2 wherein the linear array is part of a larger two-dimensional array.
4. The apparatus of claim 1 wherein the sample cells are part of a unitary block.
5. The apparatus of claim 1 wherein the coherent light source is positioned to provide an optical axis that is at least generally horizontal and wherein the detectors in the plurality of detectors are each positioned to receive light in a generally horizontal direction from one side of its corresponding sample cell.
6. The apparatus of claim 1 wherein the coherent light source is positioned to provide an optical axis that is at least generally horizontal and wherein the detectors in the plurality of detectors are positioned to receive light in a generally horizontal direction from alternating sides of corresponding sample cells.
7. The apparatus of claim 1 wherein the coherent light source is positioned to provide an optical axis that is at least generally horizontal and wherein the detectors in the plurality of detectors are positioned to receive light in a generally vertical direction from bottom surfaces of corresponding sample cells.
8. The apparatus of claim 1 wherein the coherent light source is positioned to provide an optical axis that is at least generally horizontal and wherein the detectors in the plurality of detectors are positioned to receive light in a generally vertical direction from tops of corresponding sample cells.
9. The apparatus of claim 1 wherein the coherent light source is a laser.
10. The apparatus of claim 1 wherein the coherent light source is an unfocussed laser.
11. The apparatus of claim 1 further including an environmental control system proximate the plurality of cells for regulating the temperature of the plurality of cells.
12. The apparatus of claim 1 further including one or more lenses disposed between the sample cells in the plurality of sample cells.
13. The apparatus of claim 1 wherein the detectors are photon counting detectors and wherein the light scattering analysis logic is dynamic light scattering analysis logic.
14. The apparatus of claim 1 wherein the light scattering analysis logic is static light scattering analysis logic.
15. The apparatus of claim 1 wherein at least part of the sample cells is disposable.
16. The apparatus of claim 1 further including parallel loading fluid handling equipment operative to simultaneously load the liquid samples into the sample cells.
17. The apparatus of claim 16 wherein the parallel loading fluid handling equipment is operative to simultaneously transfer a plurality of liquid samples from a multi-well plate to the plurality of sample cells.
18. A multi-sample liquid scattering measurement method, comprising:
shining a beam of coherent light along an optical axis that simultaneously passes through a plurality of liquid samples held in sample cells,
detecting light scattered from each of the liquid samples, and
deriving properties of the liquid samples based on amounts of the detected light.
19. The method of claim 18 further including the step of simultaneously transferring the liquid samples from a multi-well plate to the plurality of a sample cells before the step of shining a beam.
20. A multi-sample liquid scattering measurement apparatus, including:
means for shining a beam of coherent light along an optical axis that simultaneously passes through a plurality of liquid samples held in sample cells,
means for detecting light scattered from each of the liquid samples, and
means for deriving properties of the liquid samples based on amounts of the detected light.