Pyrimidine compounds and their uses

1. A method of treatment of COPD in a mammal comprising administering an effective amount of a compound of formula (I), their tautomeric forms, stereoisomers or pharmaceutically acceptable salts, to the mammal in need thereof

wherein

A represents substituted or unsubstituted aryl group;

B represents substituted or unsubstituted groups selected from aryl or pyridyl;

X represents carbon or nitrogen atom;

R represents substituted or unsubstituted groups selected from azido; halogens; linear or branched alkyl groups comprising methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, t-butyl, n-pentyl, isopentyl and hexyl; alkoxy groups comprising methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy and t-butoxy; haloalkyl groups comprising dichloromethyl, difluoromethyl, trifluoromethyl and trichloromethyl; acyl groups comprising acetyl and propanoyl; cycloalkyl groups comprising cyclopropyl, cyclobutyl and cyclopentyl; amino; hydrazine; monoalkylamino; dialkylamino; acylamino groups comprising acetylamino and propanoylamino; alkylsulfonyl groups comprising methylsulfonyl, ethylsulfonyl and propylsulfonyl; alkylsulfinyl; arylsulfonyl; arylsulfinyl; alkoxycarbonyl comprising methoxycarbonyl and ethoxycarbonyl; aryloxycarbonyl; alkoxyalkyl; sulfamoyl; aryl groups comprising phenyl and naphthyl; heteroaryl groups comprising pyridyl, thienyl, furyl, pyrrolyl, pyrazolyl, oxazolyl, thiazolyl, imidazolyl, thiadiazolyl, triazolyl, tetrazolyl, pyrimidinyl, pyrazinyl, benzofuranyl, benzimidazolyl and benzothiazolyl; aryloxy; —OSO 2 R′ and heterocyclyl groups comprising morpholine, thiomorpholine, piperazine, piperidine, piperidin-4-one, pyrrolidine, pyrrol-2,5-dione, thiazolidine, 1-oxido-thiazolidine and 1,1-dioxido-1,3-thiazolidine; the heterocyclyl group is optionally substituted with substitutents independently selected from substituted or unsubstituted alkyl, aryl, heteroaryl, aralkyl (—CH 2 -aryl), alkylheteroaryl (—CH 2 -heteroaryl), substituted arylcarbonyl (—CO—Ar), heteroarylcarbonyl (—CO-heteroaryl), heteroarylthiocarbonyl (—CS-heteroaryl), cycloalkylcarbonyl (—CO-cycloalkyl), cyanoalkyl, —O-methyloxime, alkylsulfonyl, haloalkylsulfonyl, haloacyl, —SO 2 Cl, formyl, hydroxamic acid and another substituted or unsubstituted heterocyclyl group; the attachment of the heterocyclyl group to the pyrimidine ring is through carbon or nitrogen; wherein R′ represents substituted or unsubstituted groups selected from alkyl, aryl, alkyldialkylamino, haloalkyl, heterocyclyl and heteroaryl groups;

R 1 represents hydrogen; hydroxy; nitro; formyl; azido; halogens; substituted or unsubstituted groups selected from alkyl; haloalkyl; alkoxy; aryl; aryloxy groups selected from phenoxy and naphthoxy; acyloxy groups comprising MeCOO—, EtCOO— and PhCOO—; amino; hydrazine; monoalkylamino; dialkylamino; acylamino; alkylsulfonyl; alkylsulfinyl; alkylthio; alkoxycarbonyl; alkoxyalkyl; sulfamoyl; —SO 2 NHNH 2 ; —SO 2 Cl; carboxylic acid and its derivatives selected from hydroxamic acid, hydroxamate, esters, amides and acid halides;

R 2 represents hydrogen; hydroxy; nitro; formyl; azido; halogens; substituted or unsubstituted groups selected from alkyl; haloalkyl; alkoxy; aryl; aryloxy; acyloxy; amino; hydrazine; monoalkylamino; dialkylamino; acylamino; alkylsulfonyl; alkylsulfinyl; alkylthio; alkoxycarbonyl; alkoxyalkyl; sulfamoyl; —SO 2 NHNH 2 ; —SO 2 Cl; carboxylic acid and its derivatives selected from hydroxamic acid, hydroxamate, esters, amides and acid halides;

R 3 represents hydrogen; hydroxy; nitro; formyl; azido; halogens; substituted or unsubstituted groups selected from alkyl; haloalkyl; alkoxy; aryl; aryloxy; acyloxy; amino; hydrazine; monoalkylamino; dialkylamino; acylamino; alkylsulfonyl; alkylsulfinyl; alkylthio; alkoxycarbonyl; alkoxyalkyl; sulfamoyl; —SO 2 NHNH 2 ; —SO 2 Cl; carboxylic acid and its derivatives selected from hydroxamic acid, hydroxamate, esters, amides and acid halides;

R 4 represents hydrogen; hydroxy; nitro; formyl; azido; halogens; substituted or unsubstituted groups selected from alkyl; haloalkyl; alkoxy; aryl; aryloxy; acyloxy; amino; hydrazine; monoalkylamino; dialkylamino; acylamino; alkylsulfonyl; alkylsulfinyl; alkylthio; alkoxycarbonyl; alkoxyalkyl; sulfamoyl; —SO 2 NHNH 2 ; —SO 2 Cl; carboxylic acid and its derivatives selected from hydroxamic acid, hydroxamate, esters, amides and acid halides;

R, R 1 , R 2 , R 3 , R 4 and R′ groups are optionally substituted by one or more substituents selected from halogens; hydroxy; nitro; cyano; ureas; azido; amino; imino-1-phenyl butanone; amide groups selected from acetamide and benzamide; thioamide; hydrazine; linear or branched alkyl groups comprising methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, t-butyl, n-pentyl, isopentyl and hexyl; alkoxy groups comprising methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy and t-butoxy; haloalkyl groups comprising dichloromethyl, difluoromethyl, trifluoromethyl and trichloromethyl; acyl groups comprising acetyl, propanoyl and benzoyl; haloalkoxy groups comprising trifluoromethoxy, trifluoroethoxy, trichloromethoxy; cycloalkyl groups comprising cyclopropyl and cyclobutyl; haloacyl groups comprising trifluoroacetyl and trichloroacetyl; acyloxyacyl; heterocyclyl; aryl; heteroaryl; monoalkylamino; dialkylamino; acylamino; aryloxy groups comprising phenoxy and naphthoxy; alkoxycarbonyl groups comprising methoxycarbonyl and ethoxycarbonyl; aryloxycarbonyl; alkylsulfonyl; haloalkylsulfonyl; —SO 2 Cl; arylsulfonyl; alkylsulfinyl; arylsulfinyl; thioalkyl; thioaryl; sulfamoyl; alkoxyalkyl groups; carboxylic acids and its derivatives comprising hydroxamic acids, hydroxamates, esters, amides and acid halides; these substituents are further optionally substituted with substituents selected from hydroxy; alkoxy; halogens; alkylsulfonyl; haloalkyl; alkyl and aryl group which in turn is optionally further substituted by halogens and alkyl.

2. A method according to claim 1 , wherein the compound of formula (I) is selected from the group consisting of:

N-({4-[4-Amino-6-[4-(methylsulfonyl)phenyl]-2-(trifluoromethyl)pyrimidin-5-yl]phenyl}sulfonyl)acetamide;

4-{4-Amino-6-[4-(methylsulfonyl)phenyl]-2-(trifluoromethyl)pyrimidin-5-yl}-N-methylbenzenesulfonamide;

4-{4-Chloro-6-[4-(methylsulfonyl)phenyl]-2-(trifluoromethyl)pyrimidin-5-yl}benzenesulfonyl chloride;

4-{4-Chloro-6-[4-(methylsulfonyl)phenyl]-2-(trifluoromethyl)pyrimidin-5-yl}-N-methylbenzenesulfonamide;

4-{4-(Methylamino)-6-[4-(methylsulfonyl)phenyl]-2-(trifluoromethyl)pyrimidin-5-yl}-N-methylbenzenesulfonamide;

N-[(4-{4-(Methylamino)-6-[4-(methylsulfonyl)phenyl]-2-(trifluoromethyl)pyrimidin-5-yl}phenyl)sulfonyl]acetamide;

4-{4-Hydrazino-6-[4-(methylsulfonyl)phenyl]-2-(trifluoromethyl)pyrimidin-5-yl}benzenesulfonohydrazide;

4-[4-(4-Fluorophenyl)-6-hydrazino-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonohydrazide;

N-[(4-{4-Hydrazino-6-[4-(methylsulfonyl)phenyl]-2-(trifluoromethyl)pyrimidin-5-yl}phenyl)sulfonyl]acetamide;

4-{4-Hydrazino-6-[4-(methylsulfonyl)phenyl]-2-(trifluoromethyl)pyrimidin-5-yl}-N-methylbenzenesulfonamide;

4-Hydrazino-5-phenyl-6-pyridin-3-yl-2-(trifluoromethyl)pyrimidine;

4-Hydrazino-5-phenyl-6-pyridin-4-yl-2-(trifluoromethyl)pyrimidine;

5-(4-Fluorophenyl)-4-hydrazino-6-pyridin-4-yl-2-(trifluoromethyl)pyrimidine;

2,2,2-Trifluoro-N-[5-(4-fluorophenyl)-6-pyridin-4-yl-2-(trifluoromethyl)pyrimidin-4-yl]acetohydrazide;

N′-[5-Phenyl-6-pyridin-4-yl-2-(trifluoromethyl)pyrimidin-4-yl]acetohydrazide;

2,2,2-Trifluoro-N′-[5-phenyl-6-pyridin-4-yl-2-(trifluoromethyl)pyrimidin-4-yl]acetohydrazide;

N-[(4-{4-Chloro-6-[4-(methylsulfonyl)phenyl]-2-(trifluoromethyl)pyrimidin-5-yl}phenyl)sulfonyl]acetamide;

6-[4-(Methylsulfonyl)phenyl]-5-phenyl-2-(trifluoromethyl)pyrimidin-4-ylnapthalenesulfonate;

6-[4-(Methylsulfonyl)phenyl]-5-phenyl-2-(trifluoromethyl)pyrimidin-4-yl-3-chloropropane-1-sulfonate;

6-[4-(Methylsulfonyl)phenyl]-5-phenyl-2-(trifluoromethyl)pyrimidin-4-yl-3-(trifluoromethyl)benzenesulfonate;

6-[4-(Methylsulfonyl)phenyl]-5-phenyl-2-(trifluoromethyl)pyrimidin-4-yl-2-(trifluoromethyl)benzenesulfonate;

6-[4-(Methylsulfonyl)phenyl]-5-phenyl-2-(trifluoromethyl)pyrimidin-4-yl-4-methylbenzenesulfonate;

6-[4-(Methylsulfonyl)phenyl]-5-phenyl-2-(trifluoromethyl)pyrimidin-4-yl-4-nitrobenzenesulfonate;

6-[4-(Methylsulfonyl)phenyl]-5-phenyl-2-(trifluoromethyl)pyrimidin-4-yl-4-trifluoromethoxybenzenesulfonate;

6-[4-(Methylsulfonyl)phenyl]-5-phenyl-2-(trifluoromethyl)pyrimidin-4-yl-thiophene-2-sulfonate;

6-[4-(Methylsulfonyl)phenyl]-5-phenyl-2-(trifluoromethyl)pyrimidin-4-yl-4-fluorobenzenesulfonate;

6-[4-(Methylsulfonyl)phenyl]-5-phenyl-2-(trifluoromethyl)pyrimidin-4-yl-2-fluorobenzenesulfonate;

6-[4-(Methylsulfonyl)phenyl]-5-phenyl-2-(trifluoromethyl)pyrimidin-4-yl-(dimethylamino)propanesulfonate;

6-[4-(Methylsulfonyl)phenyl]-5-phenyl-4-(N-benzyl-piperazin-1-yl)-2-(trifluoromethyl)pyrimidine;

4-[4-(4-Fluorophenyl)-6-piperazin-1-yl-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

4-[5-(4-Fluorophenyl)-6-piperazin-1-yl-2-(trifluoromethyl)pyrimidin-4-yl]benzenesulfonamide;

N-Methyl-4-[4-(methylsulfonyl)phenyl]-6-piperazin-1-yl-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

4-[4-(Methylsulfonyl)phenyl]-6-piperazin-1-yl-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

4-{4-(Morpholin-4yl)-6-[4-(methylsulfonyl)phenyl]-2-(trifluoromethyl)pyrimidin-5-yl}-N-methylbenzenesulfonamide;

5-{4-[4-(Methylsulfonyl)phenyl]-6-piperidin-1-yl-2-(trifluoromethyl)pyrimidin-5-yl}-N-methylbenzenesulfonamide;

4-[4-(Methylsulfonyl)phenyl]-6-{4-[(5-methylpyrazin-2-yl)carbonyl]piperazin-1-yl}-5-phenyl-2-(trifluoromethyl)pyrimidine;

6-[4-(Methylsulfonyl)phenyl]-5-phenyl-4-{4-[(1-methyl-1H-pyrrol-2-yl)carbonyl]piperazin-1-yl}-2-(trifluoromethyl)pyrimidine;

6-[4-(Methylsulfonyl)phenyl]-4-[4-(5-nitro-2-furoyl)piperazin-1-yl]-5-phenyl-2-(trifluoromethyl)pyrimidine;

N-Methyl-4-{4-[4-(5-nitro-2-furoyl)piperazin-1-yl]-6-[4-(methylsulfonyl)phenyl]-2-(trifluoromethyl)pyrimidin-5-yl}benzenesulfonamide;

4-{5-[4-Fluorophenyl]-4-[4-(5-nitro-2-furoyl)piperazin-1-yl]-2-(trifluoromethyl)pyrimidin-6-yl}benzenesulfonamide;

4-{6-[4-Fluorophenyl]-4-[4-(5-nitro-2-furoyl)piperazin-1-yl]-2-(trifluoromethyl)pyrimidin-5-yl}benzenesulfonamide;

6-[4-(Methylsulfonyl)phenyl]-4-{4-[(5-nitro-1H-pyrazol-3-yl)carbonyl]piperazin-1-yl}-5-phenyl-2-(trifluoromethyl)pyrimidine;

5,6-Diphenyl-4-[4-(5-nitro-2-furoyl)piperazin-1-yl]-2-(trifluoromethyl)pyrimidine;

5-[4-Fluorophenyl]-4-[4-(5-nitro-2-furoyl)piperazin-1-yl]-6-pyridin-4-yl-2-(trifluoromethyl)pyrimidine;

6-[4-(Methylsulfonyl)phenyl]-5-phenyl-4-[4-(1,3-thiazol-2-ylmethyl)piperazin-1-yl]-2-(trifluoromethyl)pyrimidine;

4-[4-(Methylsulfonyl)phenyl]-5-phenyl-6-[4-(pyridin-4-ylmethyl)piperazin-1-yl]-2-(trifluoromethyl)pyrimidine;

6-[4-(Methylsulfonyl)phenyl]-4-{4-[(5-nitro-2-thienyl)methyl]piperazin-1-yl}-5-phenyl-2-(trifluoromethyl)pyrimidine;

4,5-Diphenyl-6-(4-pyridin-2-yl-piperazin-1-yl)-2-(trifluoromethyl)pyrimidine;

4-[4-(Methylsulfonyl)phenyl]-5-phenyl-6-(4-pyridin-2-yl-piperazin-1-yl)-2-(trifluoromethyl)pyrimidine;

3-[4-(4-Fluorophenyl)-6-piperazin-1-yl-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

3-[4-Phenyl-6-piperazin-1-yl-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

3-[5-(3-Aminosulfonylphenyl)]-6-piperazin-1-yl-2-(trifluoromethyl)pyrimidin-4-yl]benzenesulfonamide;

3-[4-(4-Fluorophenyl)-6-(4-pyridin-2-ylpiperazin-1-yl)-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

3-[4-(4-Fluorophenyl)-6-(4-pyrimidin-2-ylpiperazin-1-yl)-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

3-[4-Phenyl-6-(1,3-thiazolidin-3-yl)-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

3-[6-[(4-Hydroxycyclohexyl)amino]-5-(3-aminosulfonylphenyl)-2-(trifluoromethyl)pyrimidin-4-yl]benzenesulfonamide;

3-[6-(4-Pyrimidin-2-ylpiperazin-1-yl)]-4-phenyl-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

3-[6-(4-Pyridin-2-ylpiperazin-1-yl)]-4-phenyl-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

Ethyl-1-[5-(3-aminosulfonylphenyl)-6-(4-fluorophenyl)-2-(trifluoromethyl)pyrimidin-4-yl]piperidine-4-carboxylate;

3-[4-[(4-Hydroxycyclohexyl)amino]-6-(4-fluorophenyl)-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

Ethyl 1-[6-phenyl-5-(3-aminosulfonylphenyl)-2-(trifluoromethyl)pyrimidin-4-yl]piperidine-4-carboxylate;

4-[6-Phenyl-5-(3-morpholinosulfonylphenyl)-2-(trifluoromethyl)pyrimidin-4-yl]morpholine;

3-[4-(4-Fluorophenyl)-6-morpholin-4-yl-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

(3R)-1-[6-(4-Fluorophenyl)-5-(3-aminosulfonylphenyl)-2-(trifluoromethyl)pyrimidin-4-yl]pyrrolidin-3-ol;

Ethyl (2S,4R)-4-hydroxy-1-[6-(4-fluorophenyl)-5-(3-aminosulfonylphenyl)-2-(trifluoromethyl)pyrimidin-4-yl]pyrrolidine-2-carboxylate;

4-[4-(2,6-Dimethoxypyrimidin-4-yl)piperazin-1-yl]-5-(3-aminosulfonylphenyl)-6-(4-fluorophenyl)-2-(trifluoromethyl)pyrimidine;

5-(4-Fluorophenyl)-4-(4-pyridin-2-ylpiperazin-1-yl)-6-[4-(methylsulfonyl)phenyl]-2-(trifluoromethyl)pyrimidine;

4-(4-Methylsulfonylphenyl)-5-(4-fluorophenyl)-6-(4-pyrimidin-2-ylpiperazin-1-yl)-2-(trifluoromethyl)pyrimidine;

4-[5-(4-Fluorophenyl)-6-[4-(methylsulfonyl)phenyl]-2-(trifluoromethyl)pyrimidin-4-yl]piperazine-1-carbaldehyde;

1′-[5-(4-Fluorophenyl)-6-(4-methylsulfonylphenyl)-2-(trifluoromethyl)pyrimidin-4-yl]-1,4′-bipiperidine;

3-[4-(4-Fluorophenyl)-6-(1,4′-bipiperidin-1′-yl)-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

3-[4-(2-Furoyl)piperazin-1-yl)-6-(4-fluorophenyl)-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

5-(3-Aminosulfonylphenyl)-4-(4-fluorophenyl)-2-(trifluoromethyl)-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine;

5-(4-Fluorophenyl)-4-(4-methylsulfonylphenyl)-2-(trifluoromethyl)-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine;

3-[4-(4-Fluorophenyl)-6-(1,3-thiazolidin-3-yl)-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

1-[5-[3-(Aminosulfonyl)phenyl]-6-(4-fluorophenyl)-2-(trifluoromethyl)pyrimidin-4-yl]pyrrolidine-2-carboxamide;

5-(3-Aminosulfonylphenyl)-4-(4-fluorophenyl)-2-(trifluoromethyl)-6-{4-[(trifluoromethyl)sulfonyl]piperazin-1-yl}pyrimidine;

3-[4-[4-(Methylsulfonyl)piperazin-1-yl]-6-(4-fluorophenyl)-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

3-[4-[4-(Cyanomethyl)piperazin-1-yl]-6-(4-fluorophenyl)-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

3-[4-(4-Fluorophenyl)-6-(1-imidazol-1-yl)-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

5-(4-Fluorophenyl)-4-(1H-imidazol-1-yl)-6-[4-(methylsulfonyl)phenyl]-2-(trifluoromethyl)pyrimidine;

3-[6-(4-Fluorophenyl)-4-(morpholin-4-yl)-2-(trifluoromethyl)pyrimidin-5-yl]-N-cyclopropylbenzenesulfonamide;

3-[6-(4-Fluorophenyl)-4-(4-methylpiperazin-1-yl)-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

3-[6-(4-Fluorophenyl)-4-(2-methyl-5-nitro-1H-imidazol-1-yl)-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

3-[6-(4-Fluorophenyl)-4-(4-oxopiperidin-1-yl)-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

3-[4-(Cyclopropylamino)-6-(4-fluorophenyl)-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

3-[6-(4-Fluorophenyl)-4-(4-phenyl-1-imidazol-1-yl)-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

3-[6-(4-Fluorophenyl)-4-(2,6-dimethylmorpholin-4-yl)-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

3-[6-(4-Fluorophenyl)-4-(2,6-dimethylpiperazin-4-yl)-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

3-[6-(4-Fluorophenyl)-4-(2-methylpiperazin-4-yl)-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

3-[6-(4-Fluorophenyl)-4-(1H-1,2,4-triazol-1-yl)-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

3-[6-(4-Fluorophenyl)-4-(3-amino-1H-pyrazol-1-yl)-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

3-[6-(4-Fluorophenyl)-4-(thiomorpholin-4-yl)-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

3-[6-(4-Fluorophenyl)-4-({2-[(methylsulfonyl)amino]ethyl}amino)-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

3-{6-(4-Fluorophenyl)-4-[3-methyl-4-(methylsulfonyl)piperazin-1-yl]-2-trifluoromethylpyrimidin-5-yl}benzenesulfonamide;

3-{6-(4-Fluorophenyl)-4-[3-(hydroxymethyl)-4-(4-fluorophenyl)piperidin-1-yl]-2-(trifluoromethyl)pyrimidin-5-yl}benzenesulfonamide;

3-[4-Morpholin-4-yl-2-(trifluoromethyl)-6-phenyl-pyrimidin-5-yl]benzenesulfonamide;

3-[6-(4-Fluorophenyl)-4-(2-morpholin-4-ylethoxy)-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

3-{4-[4-(2-Cyanoethyl)piperazin-1-yl]-6-(4-fluorophenyl)-2-(trifluoromethyl)pyrimidin-5-yl}benzenesulfonamide;

3-{6-(4-Fluorophenyl)-4-[3-methyl-4-(pyridin-2-yl-methyl)piperazin-1-yl]-2-(trifluoromethyl)pyrimidin-5-yl}benzenesulfonamide;

3-{6-(4-Fluorophenyl)-4-[3-methyl-4-(3-methoxybenzyl)piperazin-1-yl]-2-(trifluoromethyl)pyrimidin-5-yl}benzenesulfonamide;

3-(6-(4-Fluorophenyl)-4-[4-(pyridin-2-yl-methyl)piperazin-1-yl]-2-(trifluoromethyl)pyrimidin-5-yl)benzenesulfonamide;

3-(6-(4-Fluorophenyl)-[4-(3-methoxybenzyl)piperazin-1-yl]-2-(trifluoromethyl)pyrimidin-5-yl)benzenesulfonamide;

3-{6-(4-Fluorophenyl)-[4-(2-hydroxyethyl)piperazin-1-yl]-2-(trifluoromethyl)pyrimidin-5-yl}benzenesulfonamide;

3-(6-(4-Fluorophenyl)-4-[4-(1H-imidazol-1-ylcarbonothioyl)piperazin-1-yl]-2-(trifluoromethyl)pyrimidin-5-yl)benzenesulfonamide;

3-[4-(1,1-Dioxido-1,3-thiazolidin-3-yl)-6-(4-fluorophenyl)-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

3-[6-(4-Fluorophenyl)-4-(1-oxido-1,3-thiazolidin-3-yl)-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

3-{6-(4-Fluorophenyl)-4-[4-(trifluoroacetyl)piperazin-1-yl]-2-(trifluoromethyl)pyrimidin-5-yl}benzenesulfonamide;

3-{6-(4-Fluorophenyl)-4-[4-(2-fluorobenzoyl)piperazin-1-yl]-2-trifluoromethylpyrimidin-5-yl}benzenesulfonamide;

4-{5-[3-(Aminosulfonyl)phenyl]-6-(4-fluorophenyl)-2-(trifluoromethyl)pyrimidin-4-yl}piperazine-1-sulfonyl chloride;

3-(4-[4-(Cyclopropylcarbonyl)piperazin-1-yl]-6-(4-fluorophenyl)-2-(trifluoromethyl)-pyrimidin-5-yl)benzenesulfonamide;

3-{6-(4-Fluorophenyl)-4-[4-(methoxyimino)piperidin-1-yl]-2-(trifluoromethyl)pyrimidin-5-yl}benzenesulfonamide;

3-{6-(4-Fluorophenyl)-4-[(3-methyl-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)amino]-2-(trifluoromethyl)pyrimidin-5-yl}benzenesulfonamide;

3-{4-[(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)amino]-6-(4-fluorophenyl)-2-(trifluoromethyl)pyrimidin-5-yl}benzenesulfonamide;

3-[6-{4-[5-(Trifluoromethyl)pyridin-2-yl]piperazin-1-yl}-4-phenyl-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

3-[6-{4-[2,6-Dimethoxypyrimidin-4-yl]piperazin-1-yl}-4-phenyl-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

3-[6-{4-[5-(Nitro)pyridin-2-yl]piperazin-1-yl}-4-phenyl-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

3-[6-{4-[5-(Amino)pyridin-2-yl]piperazin-1-yl}-4-[4-fluorophenyl]-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

4-[5-(Acetylamino)pyridin-2-yl]piperazin-1-yl-5-(4-fluorophenyl)-6-[4-(methylsulfonyl)phenyl]-2-(trifluoromethyl)pyrimidine;

N-({3-[4-Pyridin-2-yl]piperazin-1-yl)-6-(4-fluorophenyl)-2-(trifluoromethyl)pyrimidin-5-yl]phenyl}sulfonyl)acetamide;

4-Fluorophenyl-5-(3-propionylaminosulfonylphenyl)-6-([4-pyridin-2-yl]piperazin-1-yl)-2-(trifluoromethyl)pyrimidine;

1-{5-[3-(Aminosulfonyl)phenyl]-6-(4-fluorophenyl)-2-(trifluoromethyl)pyrimidin-4-yl}piperidine-4-carboxylic acid;

4-[4-(Methoxyaminocarbonyl)piperidin-1-yl}-5-(4-fluorophenyl)-6-[4-(methylsulfonyl)phenyl]-2-(trifluoromethyl)pyrimidine;

1-{5-[3-(Aminosulfonyl)phenyl]-6-(4-fluorophenyl)-2-(trifluoromethyl)pyrimidin-4-yl}-N-hydroxypiperidine-4-carboxamide;

Methyl-3-methoxy-4-({6-[4-(methylsulfonyl)phenyl]-5-(4-fluorophenyl)-2-(trifluoromethyl)pyrimidin-4-yl}oxy)benzoate;

3-Methoxy-4-({6-(4-fluorophenyl)-5-[3-(aminosulfonyl)phenyl]-2-(trifluoromethyl)pyrimidin-4-yl}oxy)-N-methoxybenzamide;

4-{[5-(4-Fluorophenyl)-6(4-methylsulfonylphenyl)-2-(trifluoromethyl)pyrimidin-4-yl]oxy}-N,3-dimethoxybenzamide;

5-Amino-1-[5,6-diphenyl-2-(trifluoromethyl)pyrimidin-4-yl]-3-methyl-1H-pyrazole-4-carbonitrile;

Ethyl-5-amino-1-[5,6-diphenyl-2-(trifluoromethyl)pyrimidin-4-yl]-3-(methylthio)-1H-pyrazole-4-carboxylate;

5-Amino-1-[5,6-diphenyl-2-(trifluoromethyl)pyrimidin-4-yl]-1H-pyrazole-4-carbonitrile;

3-t-Butyl-1-[5,6-diphenyl-2-(trifluoromethyl)pyrimidin-4-yl]-1H-pyrazol-5-amine;

4-(3,5-Dimethyl-1H-pyrazol-1-yl)-5,6-diphenyl-2-(trifluoromethyl)pyrimidine;

3-[4-(5-Amino-4-cyano-3-methyl-1H-pyrazol-1-yl)-6-(4-fluorophenyl)-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

Ethyl-5-amino-1-[5-[3-(aminosulfonyl)phenyl]-6-(4-fluorophenyl)-2-(trifluoromethyl)pyrimidin-4-yl]-3-(methylthio)-1H-pyrazole-4-carboxylate;

4-[4-(Methylsulfonyl)phenyl]-5-phenyl-2-(trifluoromethyl)-6-[5-(trifluoromethyl)-1H-pyrazol-1-yl]pyrimidine;

5-Amino-1-[5,6-diphenyl-2-(trifluoromethyl)pyrimidin-4-yl]-1H-pyrazole-4-carbothioamide;

(3Z)-4,4,4-Trifluoro-1-phenylbutane-1,3-dione-3-{[5-phenyl-6-(4-methylsulfonylphenyl)-2-(trifluoromethyl)pyrimidin-4-yl]hydrazone};

N-{1-[5,6-Diphenyl-2-(trifluoromethyl)pyrimidin-4-yl]-3-t-butyl-1H-pyrazol-5-yl}-4-methoxybenzamide;

N-{1-[5,6-Diphenyl-2-(trifluoromethyl)pyrimidin-4-yl]-3-t-butyl-1H-pyrazol-5-yl}-3-fluorobenzamide;

N-{1-[5,6-Diphenyl-2-(trifluoromethyl)pyrimidin-4-yl]-3-t-butyl-1H-pyrazol-5-yl}-4-(trifluoromethyl)benzamide;

Ethyl-5-amino-1-[5-phenyl-6-[4-(methylsulfonyl)phenyl]-2-(trifluoromethyl)pyrimidin-4-yl]-3-(methylthio)-1H-pyrazole-4-carboxylate;

5-Amino-1-[5,6-diphenyl-2-(trifluoromethyl)pyrimidin-4-yl]-3-(methylthio)-N-phenyl-1H-pyrazole-4-carboxamide;

5-Amino-N-(4,5-dimethylphenyl)-1-[5-(4-fluorophenyl)-6-pyridin-4-yl-2-(trifluoromethyl)pyrimidin-4-yl]-3-(methylthio)-1H-pyrazole-4-carboxamide;

1-(2,6-Dichlorophenyl)-3-{1-[5,6-diphenyl-2-(trifluoromethyl)pyrimidin-4-yl]-3-t-butyl-1H-pyrazol-5-yl}urea;

4-[4-(Methylthio)phenyl]-5,6-diphenyl-2-(trifluoromethyl)pyrimidine;

5-Phenyl-4-[4-(methylsulfonyl)phenyl]-6-[4-(methylthio)phenyl]-2-(trifluoromethyl)pyrimidine;

3-[4-(3,5-Dimethylpiperazin-1-yl)-6-phenyl-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

3-{4-[(3S)-3-Methylpiperazin-1-yl]-6-phenyl-2-(trifluoromethyl)pyrimidin-5-yl}benzenesulfonamide;

3-[4-(2,6-Dimethylmorpholin-4-yl)-6-phenyl-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

2,2,2-Trifluoro-N-({3-[6-phenyl-4-(4-(trifluoroacetyl)piperazin-1-yl)-2-(trifluoromethyl)pyrimidin-5-yl]phenyl}sulfonyl)acetamide;

3-[4-(2-Amino-1H-imidazol-1-yl)-6-phenyl-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

5-(4-Chlorophenyl)-6-[4-(methylsulfonyl)phenyl]-4-(piperazin-1-yl)-2-(trifluoromethyl)pyrimidine;

4,5-Diphenyl-6-[4-(methylsulfonyl)piperazin-1-yl]-2-(trifluoromethyl)pyrimidine;

4-[5-(4-Chlorophenyl)-6-[4-(methylsulfonyl)phenyl]-2-trifluoromethyl-pyrimidin-4-yl]morpholine;

2-Chloro-4-fluoro-5-({4-[6-(4-methylsulfonylphenyl)-5-phenyl-2-(trifluoromethyl)pyrimidin-4-yl]piperazin-1-yl}sulfonyl)benzoic acid;

2-Chloro-4-fluoro-5-({4-[6-(4-methylsulfonylphenyl)-5-phenyl-2-(trifluoromethyl)pyrimidin-4-yl]piperazin-1-yl}sulfonyl)benzoic acid sodium salt;

4-{4-[(2-Chloro-4-fluorophenyl)sulfonyl]piperazin-1-yl}-6-(4-methylsulfonyl phenyl)-5-phenyl-2-(trifluoromethyl)pyrimidine;

4-(4-Methylsulfonylphenyl)-5-phenyl-6-[4-((4-chlorophenyl)phenyl-methyl)piperazin-1-yl]-2-(trifluoromethyl)pyrimidine;

Ethyl 4-[5-phenyl-6-(4-methylsulfonylphenyl)-2-(trifluoromethyl)pyrimidin-4-yl]piperazine-1-carboxylate;

t-Butyl 4-[5-phenyl-6-(4-methylsulfonylphenyl)-2-(trifluoromethyl)pyrimidin-4-yl]piperazine-1-carboxylate;

6-(4-Methylphenyl)-5-phenyl-4-(4-(pyrimidin-2-yl)-piperazin-1-yl)-2-(trifluoromethyl)pyrimidine;

6-(4-Fluorophenyl)-5-phenyl-4-(1,3-thiazolidin-3-yl)-2-(trifluoromethyl)pyrimidine;

6-(4-Fluorophenyl)-5-phenyl-4-(4-(pyrimidin-2-yl)-piperazin-1-yl-2-(trifluoromethyl)pyrimidine;

6-(4-Fluorophenyl)-N-(4-methylpiperazin-1-yl)-5-phenyl-2-(trifluoromethyl)pyrimidin-4-amine;

3-[4-(1H-imidazol-1-yl)-5-phenyl-2-(trifluoromethyl)pyrimidin-6-yl]benzenesulfonamide;

3-[4-(4-Acetylpiperazin-1-yl)-6-(4-Fluorophenyl)-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

1-{5-[3-(Aminosulfonyl)phenyl]-6-phenyl-2-(trifluoromethyl)pyrimidin-4-yl}piperidine-4-carboxylic acid;

N-({3-[4-(4-Acetylpiperazin-1-yl)-6-phenyl-2-(trifluoromethyl)pyrimidin-5-yl]phenyl}sulfonyl)acetamide;

3-[4-(1-Oxido-1,3-thiazolidin-3-yl)-6-phenyl-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

3-{6-Phenyl-4-[4-(trifluoroacetyl)piperazin-1-yl]-2-(trifluoromethyl)pyrimidin-5-yl}benzenesulfonamide;

3-[4-(Cyclopropylamino)-6-(4-methylsulfonylphenyl)-2-(trifluoromethyl)pyrimidin-5-yl]-N-methylbenzenesulfonamide;

N-Cyclopropyl-6-(4-fluorophenyl)-5-phenyl-2-(trifluoromethyl)pyrimidin-4-amine;

5-Phenyl-6-(4-methylphenyl)-2-(trifluoromethyl)-4-{4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}pyrimidine;

1-[6-(4-Methylphenyl)-5-phenyl-2-(trifluoromethyl)pyrimidin-4-yl]piperidin-4-one;

3-{4-[4-(Hydroxymethyl)piperidin-1-yl]-6-phenyl-2-(trifluoromethyl)pyrimidin-5-yl}benzenesulfonamide;

3-[6-Phenyl-4-(4-oxopiperidin-1-yl)-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

3-(4-[4-(2-Furoyl)piperazin-1-yl]-6-phenyl-2-(trifluoromethyl)pyrimidin-5-yl)benzenesulfonamide;

6-(4-Methylphenyl)-5-phenyl-4-[4-(2-propylpentanoyl)piperazin-1-yl]-2-(trifluoromethyl)pyrimidine;

N-Cyclopropyl-6-(4-methylphenyl)-5-phenyl-2-(trifluoromethyl)pyrimidin-4-amine;

4-[6-(4-Fluorophenyl)-4-(4-methylpiperazin-1-yl)-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

4-[6-(4-Fluorophenyl)-4-(morpholin-4-yl)-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

3-[4-(2-Methyl-1H-imidazol-1-yl)-6-phenyl-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide; and

6-[4-(Methylsulfonyl)phenyl]-5-phenyl-4-[4-(2-thienylcarbonyl)piperazin-1-yl]-2-(trifluoromethyl)pyrimidine.

3. A method according to claim 1 , wherein the compound is selected from the group consisting of:

4-{4-(Morpholin-4yl)-6-[4-(methylsulfonyl)phenyl]-2-(trifluoromethyl)pyrimidin-5-yl}-N-methylbenzenesulfonamide;

3-[4-(4-Fluorophenyl)-6-morpholin-4-yl-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

3-[6-(4-Fluorophenyl)-4-(morpholin-4-yl)-)-2-(trifluoromethyl)pyrimidin-5-yl]-N-cyclopropylbenzenesulfonamide;

3-[6-(4-Fluorophenyl)-4-(2,6-dimethylmorpholin-4-yl)-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

3-[4-Morpholin-4-yl-2-(trifluoromethyl)-6-phenyl-pyrimidin-5-yl]benzenesulfonamide;

3-[4-(2,6-Dimethylmorpholin-4-yl)-6-phenyl-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide;

4-[5-(4-Chlorophenyl)-6-[4-(methylsulfonyl)phenyl]-2-(trifluoromethyl)pyrimidin-4-yl]morpholine;

4-[6-(4-Fluorophenyl)-4-(morpholin-4-yl)-2-(trifluoromethyl)pyrimidin-5-yl]benzenesulfonamide; and

3-[4-(Morpholin-N-yl)-6-(4-fluorophenyl)-2-(trifluoromethyl)pyrimidin-5-yl]-N-cyclopropylbenzenesulfonamide.

4. A method according to claim 1 , wherein the compound is 3-[4-Morpholin-4-yl-2-(trifluoromethyl)-6-phenyl-pyrimidin-5-yl]benzenesulfonamide and its pharmaceutically acceptable salts.