Blood substitute solution
The invention relates generally to blood substitute solutions and methods for using blood substitute solutions. The solutions may be used in a variety of applications and are particularly suited for use in applications where at least a portion of a host's blood is replaced with a substitute solution.
1. A physiologically acceptable solution suitable for administration as a blood substitute, wherein said composition comprises:
0.01-3.0 L distilled water
0.1-0.5 gm/L calcium chloride
0.1-0.5 gm/L potassium chloride
0.01-0.25 gm/L potassium phosphate
0.05-0.5 gm/L magnesium chloride
0.05-0.5 gm/L magnesium sulfate
5-10 gm/L sodium chloride
0.25-0.75 gm/L sodium bicarbonate
0.01-0.1 gm/L sodium phosphate
0.1-1.0 gm/L pyruvate
0.1-1.0 gm/L glutathione
0.05-0.5 gm/L ascorbic acid
0.5-2.5 gm/L L-Arginine
0.1-1.0 gm/L L-Taurine
0.1-1.0 gm/L Beta-alanine
0.1-0.5 gm/L creatine monohydrate
0.5-1.5 gm/L L-Carnitine
1.0-5.0 gm/L L-Carnosine.
2. The solution of claim 1 , wherein said solution further comprises D-glucose.
3. The solution of claim 1 , wherein said solution further comprises 3-beta hydroxy butyrate.
4. The solution of claim 1 , wherein said solution further comprises alpha-ketoglutarate.
5. The solution of claim 1 , wherein said solution further comprises acetoacetate.
6. The solution of claim 1 , wherein said solution further comprises and intralipid solution.
7. A physiologically acceptable solution suitable for administration as a blood substitute, wherein said composition comprises:
Calcium chloride (1.3 mM)
Potassium chloride (4.0 mM)
Potassium phosphate (monobasic; 0.5 mM)
Magnesium chloride (hexahydrate; 0.5 mM)
Magnesium sulfate (heptahydrate; 0.5 mM)
Sodium chloride (130 mM)
Sodium bicarbonate (5.0 mM)
Sodium phosphate (dibasic; hepatahydrate; 0.19 mM)
Pyruvate (5 mM)
Glutathione (reduced; 1.5 mM)
Ascorbic acid (1 mM)
L-Arginine (5 mM)
L-Taurine (5 mM)
Beta-alanine (5 mM)
Creatine monohydrate (2 mM)
L-Carnitine (5 mM)
L-Carnosine (10 mM).