Granted Patent
B2
US 9,737,478 · App. 12/881,124 · Granted Aug 22, 2017
Treatment of malaria
A61K9/0019A61K9/0004A61K9/2004A61K9/2806A61K31/137A61K31/155A61K31/357A61K31/365A61K31/4706A61K31/4709A61K31/49A61K31/505A61K45/06
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Abstract
The invention contemplates compositions for the treatment of malaria comprising an anti-malaria drug and an adjuvant which promotes vasodilation and methods of using same.
Claims (3)
1. A method for the treatment of cerebral malaria, said method comprising simultaneously or serially administering to said mammal a therapeutically effective amount of an artemisinin or an artemisinin derivative, and nimodipine in a therapeutically effective amount to promote vasodilation.
2. The method of claim 1 wherein the artemisinin derivative is selected from artesunate, artemether, and arteether.
3. The method of claim 1 , comprising administering a single formulation comprising nimodipine and artemisinin or an artemisinin derivative.
Assignments (2)
CONFIRMATORY LICENSE
Recorded Dec 7, 2010
From: LA JOLLA BIOENGINEERING INSTITUTE
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 025445/0945 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Sep 14, 2010
From: CARVALHO, LEONARDO JOSE DE MOURA; CABRALES, PEDRO
To: LA JOLLA BIOENGINEERING INSTITUTE
Reel/Frame 024986/0417 →
Continuity (2)
Provisional Application
61246507
· Sep 28, 2009