Development of new selective estrogen receptor modulators
View Patent ↗The present disclosure concerns a new class of selective estrogen receptor modulators (SERMs). The disclosure also includes the identification of a previously unknown membrane associated estrogen receptor. Methods for making and using the disclosed SERMs are disclosed, including pharmaceutical formulations of the disclosed novel compounds in useful compositions.
1. A method for treating a condition associated with estrogen insufficiency in a subject, the condition comprising a disorder of temperature regulation, the method comprising administering to the subject an effective amount of a compound according to formula I:
2. The method of claim 1 , wherein the disorder of temperature regulation comprises hot flushes.
3. The method of claim 1 , further comprising administering an effective amount of a second compound comprising a steroid hormone to the subject.
4. The method of claim 1 , further comprising administering an effective amount of a second compound comprising a selective estrogen receptor modulator to the subject.