METHODS FOR TREATING SKIN DISORDERS WITH TOPICAL NITROGEN MUSTARD COMPOSITIONS
Provided are methods for treating skin disorders comprising topically applying to the affected skin a composition comprising a nitrogen mustard or a pharmaceutically acceptable salt thereof.
1 . A method for treating mycosis fungoides comprising topically applying to the affected skin a composition comprising an effective amount of bis-(2-chloroethyl)methylamine or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient, wherein the response rate in a group of human patients is greater than about 60% after at least six months of treatment.
2 . The method of claim 1 , wherein the bis-(2-chloroethyl)methylamine or pharmaceutically acceptable salt thereof is present in an amount of about 0.015% to about 0.030% by weight of the composition.
3 . The method of claim 1 , wherein the bis-(2-chloroethyl)methylamine or pharmaceutically acceptable salt thereof is present in an amount of about 0.01% to about 0.10% by weight of the composition.
4 . A method for treating mycosis fungoides comprising topically applying to the affected skin a composition comprising an effective amount of bis-(2-chloroethyl)methylamine or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient, wherein the response rate in a group of human patients is greater than about 55% upon two months of treatment.
5 . The method of claim 4 , wherein the bis-(2-chloroethyl)methylamine or pharmaceutically acceptable salt thereof is present in an amount of about 0.015% to about 0.030% by weight of the composition.
6 . The method of claim 4 , wherein the bis-(2-chloroethyl)methylamine or pharmaceutically acceptable salt thereof is present in an amount of about 0.01% to about 0.10% by weight of the composition.
7 . A method for treating mycosis fungoides comprising topically applying to the affected skin a composition comprising an effective amount of bis-(2-chloroethyl)methylamine or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient, wherein the response rate in an intent-to-treat group of human patients is greater than about 50%.
8 . The method of claim 7 , wherein the bis-(2-chloroethyl)methylamine or pharmaceutically acceptable salt thereof is present in an amount of about 0.015% to about 0.030% by weight of the composition.
9 . The method of claim 7 , wherein the bis-(2-chloroethyl)methylamine or pharmaceutically acceptable salt thereof is present in an amount of about 0.01% to about 0.10% by weight of the composition.
10 . A method for treating mycosis fungoides comprising topically applying to the affected skin a composition comprising an effective amount of bis-(2-chloroethyl)methylamine or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient, wherein the time to achieve a response rate of 50% in a group of human patients is about 40 weeks or less.
11 . The method of claim 10 , wherein the response rate is about 30 weeks or less.
12 . The method of claim 10 , wherein the bis-(2-chloroethyl)methylamine or pharmaceutically acceptable salt thereof is present in an amount of about 0.015% to about 0.030% by weight of the composition.
13 . The method of claim 10 , wherein the bis-(2-chloroethyl)methylamine or pharmaceutically acceptable salt thereof is present in an amount of about 0.01% to about 0.10% by weight of the composition.