Delivery agent
A composition and method comprising a polycationic agent and a polyanionic agent for delivering a peptide or protein into a cell.
1. A composition for delivering a peptide or protein into a cell, the composition comprising:
a polycationic delivery agent comprising a polyalkyleneimine or a polyhydroxyalkyleneimine and one of
(a) a polyoxometalate, or
(b) (PO 3 )x where x is 12-13.
2. The composition according to claim 1 , wherein the polyoxometalate comprises a molybdenum or tungsten polyoxometalate and optionally carries a heteroatom.
3. The composition according to claim 1 , wherein the polycationic agent comprises a polyhydroxyalkyleneimine.
4. The composition according to claim 3 , wherein the polyhydroxyalkyleneimine is polyhydroxypropyleneimine.
5. The composition according to claim 1 , wherein the polyalkyleneimine comprises a polyethyleneimine.
6. A pharmaceutical product comprising
a peptide or protein,
a polycationic delivery agent, and
a polyanionic delivery agent
as a combined preparation, where the polyanionic delivery agent comprises
(a) a polyoxometalate, or
(b) (PO 3 )x where x is 12-13, and
where the polycationic delivery agent comprises a polyalkyleneimine or a polyhydroxyalkyleneimine.