Method and composition for delivering zinc to the nasal membrane
A viscous gel for delivering minor effective amounts of active substances through the nasal membrane into the body.
1. A gel composition for delivering an active substance to a nasal membrane, the composition comprising:
a zinc active substance present in sufficient amount in the gel composition to provide at least 4 mM to about 60 mM zinc ions in the gel composition;
sodium chloride as an agent to facilitate diffusion of the active substance through mucous in the nasal passage;
0.05 to 5 wt % glycerin
90 to 99 wt % purified water; and
0.000001% to 5 wt %, thickening agent selected from the group consisting of carrageenan, sugar, guar gum, hydroxycellulose, methylcellulose, and hydroxyethylcellulose.
2. The gel composition of claim 1 , wherein the thickening agent is hydroxyethylcellulose.
3. The gel composition of claim 1 , wherein the active substance comprises zinc gluconate.
4. The gel composition of claim 1 , wherein the composition comprises less than 1.5 wt % zinc gluconate.
5. The gel composition of claim 1 , further comprising a permeation enhancer.
6. The gel composition of claim 1 , comprising about 0.9 to about 2.0 weight percent zinc gluconate.
7. The gel composition of claim 1 , comprising 0.1 to 3 wt % of the thickening agent.
8. The gel composition of claim 1 , comprising 0.185 wt % to 2.8 wt % zinc gluconate.
9. The gel composition of claim 1 , comprising about 20 to 44 mM zinc ion.
10. The gel composition of claim 1 , wherein the viscosity of the composition is between 2,500 cp and 40,000 cp.
11. The gel composition of claim 1 , wherein the viscosity of the composition is between 5,000 cp and 20,000 cp.
12. A method of treating a cold, comprising the step of administering an effective amount of the gel composition of claim 1 to a nasal membrane.
13. A system for applying a composition to a nasal membrane comprising an applicator and the gel composition according to claim 1 .