IP Library › Granted Patent US 10,463,689
Granted Patent B2
US 10,463,689 · App. 12/904,791 · Granted Nov 5, 2019

Pharmaceutical formulations of nitrite and uses thereof

Inventors: Christopher Kevil (Shreveport, LA); Anthony Giordano (Shreveport, LA); Douglas R. Flanagan (Iowa City, IA); Panayiotis P. Constantinides (Gurnee, IL)
Assignee: Board of Supervisors of Louisiana State University
A61K33/00A61K9/0053A61K9/2068A61K9/2866A61K9/5042
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Quick Facts
Patent No.
US 10,463,689
App. No.
12/904,791
Granted
Nov 5, 2019
Kind
B2
Abstract

The present invention relates to pharmaceutical compositions of nitrites such as inorganic nitrites, or any pharmaceutically acceptable salts, solvates, or prodrugs thereof, and the medical use of these compositions. The pharmaceutical compositions, which can be formulated for oral administration, can provide immediate release or extended release of the nitrite ion (NO 2 − ). The pharmaceutical compositions of the invention are useful, for example, for the treatment of chronic tissue ischemia.

Claims (13)

1. A sustained release pharmaceutical composition for the treatment of pain comprising:

40 mg of NaNO 2 ;

magnesium stearate;

a binding agent of polyvinyl pyrrolidone;

an enteric coating of selected from hydroxypropylmethylcellulose, methylcellulose, methyl hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, cellulose acetate phthalate, hydroxypropylmethylcellulose acetate succinate, methacrylate acid copolymers, cellulose acetate trimellitate, polyvinyl acetate phthalate, hydroxyethylcellulose phthalate, or hydroxypropyl methylcellulose phthalate; and

a pharmaceutically acceptable excipient selected from ethylcellulose, methylhydroxyethylcellulose, hydroxypropyl cellulose, cellulose acetate butyrate, and cellulose triacetate;

wherein the pharmaceutical composition does not comprise an additional active ingredient; and

wherein the pharmaceutical composition is formed as one of a tablet, capsule, caplet, and gelcap.

2. The pharmaceutical composition of claim 1 , wherein the pharmaceutically acceptable excipient is hydroxypropyl methylcellulose.

3. The pharmaceutical composition of claim 1 wherein the pharmaceutical composition is formed as a tablet.

4. The pharmaceutical composition of claim 1 wherein the pharmaceutical composition is formed as a capsule.

5. The pharmaceutical composition of claim 1 wherein the pharmaceutical composition is formed as a caplet.

6. The pharmaceutical composition of claim 1 wherein the pharmaceutical composition is formed as a gelcap.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 24, 2018
From: THERAVASC, INC.
To: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
Reel/Frame 046950/0959 →
CHANGE OF NAME Recorded Apr 11, 2012
From: THERAVASC LLC
To: THERAVASC INC.
Reel/Frame 028027/0883 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 17, 2010
From: KEVIL, CHRISTOPHER; GIORDANO, ANTHONY; FLANAGAN, DOUGLAS R.; CONSTANTINIDES, PANAYIOTIS P.
To: THERAVASC, LLC
Reel/Frame 025516/0322 →
Continuity (2)
Provisional Application 61251483 · Oct 14, 2009
Related Publication 20110086069A1 · Apr 14, 2011