Treatment of neuropathic pain using anti-thrombospondin antibodies
View Patent ↗The present invention describes methods and compositions for modulating synaptogenesis and axon and/or dendritic growth. The methods include the use of agents that modulate a thrombospondin and/or an α2δ subunit of a calcium channel.
1. A method of treating neuropathic pain in an individual comprising administering to an individual having neuropathic pain an effective amount of, an antibody that binds to a thrombospondin and blocks the interaction between the thrombospondin and one or more calcium channel subunits selected from the group consisting of α2δ1, α2δ2, α2δ3, and α2δ4.
2. The method of claim 1 , wherein the antibody specifically binds to an EGF-like domain of the thrombospondin.
3. The method of claim 1 , wherein the antibody specifically binds to the third EGF-like domain of the thrombospondin.
4. The method of claim 1 , wherein the thrombospondin is TSP1, TSP2, TSP3, TSP4, or cartilage oligomeric matrix.
5. The method of claim 1 , wherein the antibody is a polyclonal antibody or a monoclonal antibody.
6. The method of claim 1 , wherein the antibody is a chimeric antibody or a humanized antibody.