RINSE COMPOSITION FOR THE STABILIZATION OF DIAGNOSTIC BIOMARKERS
Rinse composition for the stabilization of diagnostic biomarkers. In at least one embodiment of a rinse useful to stabilize a diagnostic marker, the rinse comprises a stabilizing agent useful to completely or substantially prevent degradation or inactivation of a diagnostic marker in saliva, and a liquid.
1 . An oral rinse useful to stabilize a diagnostic marker, the rinse comprising:
a stabilizing agent useful to completely or substantially prevent degradation or inactivation of a diagnostic marker in saliva; and
a liquid.
2 . The rinse of claim 1 , wherein the stabilizing agent is selected from the group consisting of a protease inhibitor, a DNase inhibitor, and a RNase inhibitor.
3 . The rinse of claim 1 , wherein the stabilizing agent is useful to completely or substantially prevent degradation or inactivation of a diagnostic marker selected from the group consisting of a protein, a glycoprotein, a nucleic acid, an enzyme, an enzyme inhibitor, and a metabolite.
4 . The rinse of claim 1 , wherein the stabilizing agent is useful to completely or substantially prevent degradation or inactivation of a diagnostic marker indicative of a disease state.
5 . The rinse of claim 4 , wherein the disease state is selected from the group consisting of a cancer, a metabolic disease, a cardiac disease, diabetes, a bacterial infection, a viral infection, a fungal infection, and a parasitic infection.
6 . The rinse of claim 1 , wherein the stabilizing agent is capable of inhibiting degradation of a diagnostic marker to a inhibitory degree, the inhibitory degree selected from the group consisting of at least about 40%, at least about 45%, at least about 50%, at least about 55%, at least about 60%, at least about 65%, at least about 70%, at least about 75%, at least about 80%, at least about 85%, at least about 90%, at least about 95%, and at least about 99%.
7 . The rinse of claim 1 , wherein the stabilizing agent is selected from the group consisting of Fixanal® Buffer 6.0, acetic acid, aluminum hydroxide bentonite, aluminum sulfate hydrate, benzoic acid, aluminum potassium sulfate dodecahydrate, caffeine, and 3-tert-butyl-hydroxyanisole, or a combination thereof.
8 . The rinse of claim 1 , wherein the liquid is selected from the group consisting of water, a beverage containing water, and glycerin.
9 . The rinse of claim 1 , further comprising:
an anti-caking agent.
10 . The rinse of claim 1 , further comprising:
a preservative.
11 . The rinse of claim 1 , further comprising:
an emulsifying agent.
12 . The rinse of claim 1 , further comprising:
a nutrient and dietary supplement.
13 . The rinse of claim 1 further comprising:
a sequestrant.
14 . The rinse of claim 1 further comprising:
a stabilizer.
15 . The rinse of claim 1 further comprising:
a flavoring substance.
16 . The rinse of claim 1 further comprising:
an additive.
17 . The rinse of claim 1 further comprising one or more additives selected from the group consisting of an anti-caking agent, a chemical preservative, an emulsifying agent, a nutrient and dietary supplement, a sequestrant, a stabilizer, and flavoring substance.
18 . A rinse useful to stabilize a diagnostic marker, the rinse comprising:
a stabilizing agent useful to completely or substantially prevent degradation or inactivation of a diagnostic marker in saliva;
at least one rinse component selected from the group consisting of an anti-caking agent, a chemical preservative, an emulsifying agent, a nutrient and dietary supplement, a sequestrant, a stabilizer, flavoring substance, and an additive; and
a liquid;
wherein the stabilizing agent is selected from the group consisting of Fixanal® Buffer 6.0, acetic acid, aluminum hydroxide bentonite, aluminum sulfate hydrate, benzoic acid, aluminum potassium sulfate dodecahydrate, caffeine, and 3-tert-butyl-hydroxyanisole, or a combination thereof.