Delivery of active agents using a chocolate vehicle
This invention provides edible compositions comprising pharmaceutically or nutraceutically active agents in particulate form homogeneously dispersed in a fat matrix, such as chocolate or chocolate compound coating.
1. A dietary supplement comprising a chocolate matrix having calcium carbonate powder homogeneously dispersed throughout said chocolate, said calcium carbonate having a median particle size between about 10 μm and about 13 μm, said chocolate comprising a fat matrix composed of about 90% to about 100% by weight cocoa butter, said coca butter being in the Form V crystalline polymorph and having a melting point between about 35° C. and about 40° C., said chocolate matrix further comprising one or more additional active agents homogeneously dispersed therein, said one or more additional active agents selected from the group consisting of: vitamin A, vitamin C, vitamin D, vitamin E, vitamin K, thiamin, riboflavin, niacin, vitamin B6, folic acid, vitamin B12, biotin, pantothenic acid, calcium, phosphorus, iodine, magnesium, zinc, selenium, copper, manganese, chromium, molybdenum, chloride, potassium, boron, nickel, silicon, vanadium, lutein, lycopene, iron, tin, ginseng root, and ginkgo biloba leaf;
wherein the calcium carbonate and one or more additional active agents collectively comprise at least about 20% by weight of the chocolate matrix; and
wherein the apparent viscosity of the chocolate matrix comprising the calcium carbonate and one or more additional active agents, in the molten state, is between about 500 and about 200,000 cP when measured on a spindle viscometer at a spindle rate of 20 RPM at about 56° C.
2. The dietary supplement of claim 1 , wherein the apparent viscosity of the chocolate matrix comprising the one or more active agents, in the molten state, is between about 1,000 and about 100,000 cP when measured on a spindle viscometer at a spindle rate of 20 RPM at about 56° C.
3. The dietary supplement of claim 1 , wherein the apparent viscosity of the chocolate matrix comprising the one or more active agents, in the molten state, is between about 5,000 and about 50,000 cP when measured on a spindle viscometer at a spindle rate of 20 RPM at about 56° C.
4. The dietary supplement of claim 1 , wherein the apparent viscosity of the chocolate matrix comprising the one or more active agents, in the molten state, is between about 15,000 and about 30,000 cP when measured on a spindle viscometer at a spindle rate of 20 RPM at about 56° C.