Use of L-butylphthalide in the manufacture of medicaments for treatment of cerebral infarct
The present invention discloses the use of L-butylphthalide of formula (I) in the manufacture of medicaments for the prevention and treatment of cerebral infarct, especially induced by focal cerebral ischemia.
1. A method of using L-butylphthalide of formula (I) for reducing the volume of cerebral infarct in a subject suffering from cerebral infarct, comprising orally administering a therapeutically effective dose of L-butylphthalide of formula (I),
to the subject 15 minutes after ischemia to reduce the volume of the cerebral infarct.
2. The method of use according to claim 1 , wherein said cerebral infarct is induced by focal cerebral ischemia.
3. The method of use according to claim 1 , wherein the therapeutically effective dose of said L-butylphthalide is 0.1-100 mg/kg per day.
4. A method of using L-butylphthalide of formula (I) for improving neurological behavioral symptoms in a subject suffering from cerebral infarct, comprising orally administering a therapeutically effective dose of L-butylphthalide of formula (I),
to the subject 15 minutes after ischemia to improve the neurological behavioral symptoms induced by the cerebral infarct.