Processes for preparing a polymeric compound

1. A method for preparing a compound of Formula I:

or pharmaceutically acceptable salt thereof, comprising:

a) removing the Cbz groups from a compound of Formula II:

or pharmaceutically acceptable salt thereof, under a hydrogenation/hydrogenolysis condition to form the compound of Formula I, or pharmaceutically acceptable salt thereof; and

b) optionally isolating the compound of Formula I, or pharmaceutically acceptable salt thereof.

2. The method of claim 1 further comprising:

c) removing the Boc group from a compound of Formula III:

or pharmaceutically acceptable salt thereof, in the presence of an acid to form the compound of Formula II, or pharmaceutically acceptable salt thereof.

3. The method of claim 2 further comprising:

d) reacting a compound of Formula IV:

or pharmaceutically acceptable salt thereof, with a compound of Formula V:

or pharmaceutically acceptable salt thereof, in the presence of a coupling reagent and an organic base to form the compound of Formula III, or pharmaceutically acceptable salt thereof.

4. The method of claim 3 further comprising:

e) reacting a compound of Formula IV:

or pharmaceutically acceptable salt thereof, with ammonia or an ammonia producing reagent, in the presence of an activating reagent and an organic base to form a compound of Formula VI:

or pharmaceutically acceptable salt thereof; and

f) removing the Boc group from the compound of Formula VI, or pharmaceutically acceptable salt thereof, in the presence of an acid to form the compound of Formula V, or pharmaceutically acceptable salt thereof.

5. The method of claim 4 further comprising:

g) hydrolyzing a compound of Formula VII:

or pharmaceutically acceptable salt thereof, in the presence of a base to form the compound of Formula IV.

6. The method of claim 5 further comprising:

h) reacting a compound of Formula VIII:

or pharmaceutically acceptable salt thereof, with a compound of Formula IX:

or pharmaceutically acceptable salt thereof, in the presence of a coupling reagent and an organic base to form the compound of Formula VII, or pharmaceutically acceptable salt thereof.

7. The method of claim 6 further comprising:

i) hydrolyzing a compound of Formula X:

or pharmaceutically acceptable salt thereof, in the presence of a base to form the compound of Formula IX; and

j) removing the Boc group from a compound of Formula X, or pharmaceutically acceptable salt thereof, in the presence of an acid to form the compound of Formula VIII, or pharmaceutically acceptable salt thereof.

8. The method of claim 7 further comprising:

k) reacting a compound of Formula XI:

or pharmaceutically acceptable salt thereof, with a compound of Formula XII:

or pharmaceutically acceptable salt thereof, in the presence of a coupling reagent and an organic base to form the compound of Formula X, or pharmaceutically acceptable salt thereof.

9. A method for preparing a compound of formula I:

or pharmaceutically acceptable salt thereof, comprising:

a1) removing the Cbz groups from a compound of Formula II-1:

or pharmaceutically acceptable salt thereof, under a hydrogenation/hydrogenolysis condition to form the compound of Formula I, or pharmaceutically acceptable salt thereof; and

b1) optionally isolating the compound of Formula I, or pharmaceutically acceptable salt thereof.

10. The method of claim 9 further comprising:

c1) reacting a compound of Formula III-1:

or pharmaceutically acceptable salt thereof, with a compound of Formula IV-1:

or pharmaceutically acceptable salt thereof, in the presence of a coupling reagent and an organic base to form the compound of Formula II-1, or pharmaceutically acceptable salt thereof.

11. The method of claim 10 further comprising:

d1) reacting a compound of Formula VI-1:

or pharmaceutically acceptable salt thereof, with a compound of Formula VII-1:

or pharmaceutically acceptable salt thereof, in the presence of a coupling reagent and an organic base to form a compound of Formula V-1:

or pharmaceutically acceptable salt thereof; and

e1) removing the Boc group from the compound of Formula V-1, or pharmaceutically acceptable salt thereof, in the presence of an acid to form the compound of Formula III-1, or pharmaceutically acceptable salt thereof.

12. The method of claim 10 further comprising:

f1) reacting a compound of Formula VIII-1:

or pharmaceutically acceptable salt thereof, with a compound of Formula VII-1:

or pharmaceutically acceptable salt thereof, in the presence of a coupling reagent and an organic base to form a compound of Formula IX-1:

or pharmaceutically acceptable salt thereof; and

g1) removing the Boc group from the compound of Formula IX-1, or pharmaceutically acceptable salt thereof, in the presence of an acid to form the compound of Formula VI-1, or pharmaceutically acceptable salt thereof.

13. The method of claim 12 further comprising:

h1) reacting a compound of Formula XI-1:

or pharmaceutically acceptable salt thereof, with a compound of Formula XII-1:

or pharmaceutically acceptable salt thereof, optionally in the presence of an organic base to form a compound of Formula X-1:

or pharmaceutically acceptable salt thereof; and

i1) removing the Boc group from the compound of Formula X-1 or pharmaceutically acceptable salt thereof, in the presence of an acid to form the compound of Formula VIII-1, or pharmaceutically acceptable salt thereof.

14. The method of claim 12 further comprising:

j1) reacting a compound of Formula XI-1:

or pharmaceutically acceptable salt thereof, with a compound of Formula XIII-1:

or pharmaceutically acceptable salt thereof, to form the compound of Formula VII-1, or pharmaceutically acceptable salt thereof.

15. The method of claim 14 further comprising:

k1) reacting a compound of Formula XIV-1:

or pharmaceutically acceptable salt thereof, with a compound of Formula XIII-1:

or pharmaceutically acceptable salt thereof, to form the compound of Formula IV-1, or pharmaceutically acceptable salt thereof.

16. The method of claim 9 further comprising:

c2) reacting a compound of Formula III-2:

or pharmaceutically acceptable salt thereof, with a compound of Formula IV-2:

or pharmaceutically acceptable salt thereof, in the presence of a coupling reagent and an organic base to form the compound of Formula II-1, or pharmaceutically acceptable salt thereof.

17. The method of claim 16 further comprising:

d2) removing the Boc group from a compound of Formula V-2:

or pharmaceutically acceptable salt thereof, under an acidic condition to form the compound of Formula III-2, or pharmaceutically acceptable salt thereof.

18. The method of claim 17 , further comprising:

e2) reacting a compound of Formula VI-2:

or pharmaceutically acceptable salt thereof, with a compound of Formula VII-2:

or pharmaceutically acceptable salt thereof, in the presence of a coupling reagent and an organic base to form the compound of Formula V-2, or pharmaceutically acceptable salt thereof.

19. The method of claim 18 further comprising:

f2) removing the Boc group from a compound of Formula VIII-2:

or pharmaceutically acceptable salt thereof, under an acidic condition to form the compound of Formula VI-2, or pharmaceutically acceptable salt thereof.

20. The method of claim 19 further comprising:

g2) reacting a compound of Formula IX-2:

or pharmaceutically acceptable salt thereof, with a compound of Formula VII-2:

or pharmaceutically acceptable salt thereof, in the presence of a coupling reagent and an organic base to form the compound of Formula VIII-2, or pharmaceutically acceptable salt thereof.

21. The method of claim 20 further comprising:

h2) removing the Boc group from a compound of Formula X-2:

or pharmaceutically acceptable salt thereof, under an acidic condition to form the compound of Formula IX-2, or pharmaceutically acceptable salt thereof.

22. The method of claim 21 further comprising:

i2) reacting a compound of Formula VII-2:

or pharmaceutically acceptable salt thereof, with a compound of Formula XI-2:

or pharmaceutically acceptable salt thereof, in the presence of a coupling reagent and an organic base to form the compound of Formula X-2, or pharmaceutically acceptable salt thereof.

23. A compound chosen from:

or pharmaceutically acceptable salt thereof.