Composition and methods for promoting lush hair growth
Compositions, kits and methods are provided for conditioning, revitalizing, volumizing or increasing the natural pigmentation of the hair, including hair on the scalp, eyelashes, eyebrows, mustache and beard, promoting healthy growth, and treating and preventing loss, thinning or miniaturization of hair due to aging, various genetic, pathological, radiation, chemotherapy, chemical treatment, environmental or other reasons.
1. A composition comprising a compound of Formula I having the structure of
in combination with a physiologically acceptable excipient, wherein X is O, S, or CH 2 ; and R 1 is methyl, ethyl, propyl or iso-propyl.
2. The composition of claim 1 , wherein the compound is 7-(3,5-dihydroxy-2-(3-hydroxy-4-(3-(trifluoromethyl)phenoxy)-1-butenyl)cyclopentyl)-, N-ethyl, (1R-(1alpha(Z), 2beta(1E,3R*), 3alpha, 5alpha) (5-Heptenamide) having the structure of
3. The composition of claim 1 , wherein the composition is formulated for topical application.
4. The composition of claim 3 , wherein the composition is in a form of aqueous solution, emulsion, gel, lotion, or cream.
5. The composition of claim 1 , wherein the excipient is a cosmetically acceptable excipient.
6. The composition of claim 1 , wherein the excipient is a pharmaceutically acceptable excipient.
7. The composition of claim 1 , further comprising: one or more B-complex vitamin.
8. The composition of claim 1 , further comprising: panthenol or pantethine.
9. The composition of claim 1 , further comprising: a 5-alpha-reductase inhibitor.
10. The composition of claim 9 , wherein the 5-alpha-reductase inhibitor is spironolactone or Zinc PCA.
11. The composition of claim 1 , further comprising: hyaluronic acid or hyaluronate salt.
12. The composition of claim 1 , further comprising: biotin.
13. The composition of claim 1 , further comprising: glucosamine or glycosamineglycan.
14. The composition of claim 1 , further comprising: a peptide or an acylated peptide.
15. The composition of claim 1 , further comprising: hyaluronic acid, panthenol, panthetine, spironolactone, peptide, and glucosamine or glycosamineglycan.
16. The composition of claim 15 , wherein the peptide is a cosmetically acceptable tri-, tetra-, penta-, hexa-, or hepta-peptide or an acylated peptide thereof.
17. The composition of claim 1 , wherein the concentration of compound of Formula I is about 0.001-0.5% by weight of the total composition.
18. The composition of claim 1 , wherein the compound of Formula I is 5-Heptenamide at a concentration of about 0.01-0.1% by weight of the total composition.
19. A topical cosmetic or cosmeceutical composition, comprising:
i) at least one Type-F prostaglandin analogue which is a 20-carbon unsaturated carboxylic acid, with two double bonds cis at C 5 and trans at C 13 and a cyclopentane ring having hydroxy groups at C 9 and C 11 based on the structure of Type-F prostaglandin with the structure of
ii) at least one B-complex vitamin or derivative thereof, and iii) optionally at least one mucopolysaccharide.
20. The composition of claim 19 , wherein the Type-F prostaglandin analogue is bimatoprost, with the structure of
21. The composition of claim 19 , wherein the B-complex vitamin is panthenol or pantethine.
22. The composition of claim 19 , further comprising: a 5-alpha-reductase inhibitor.
23. The composition of claim 22 , wherein the 5-alpha-reductase inhibitor is spironolactone or Zinc PCA.
24. The composition of claim 19 , further comprising: glucosamine.
25. The composition of claim 19 , further comprising: biotin.
26. The composition of claim 19 , wherein the mucopolysaccharide is hyaluronic acid, hyaluronate salt or glycosamineglycan.
27. The composition of claim 19 , further comprising: a peptide or an acylated peptide.
28. The composition of claim 27 , wherein the peptide is a cosmetically acceptable tri-, tetra-, penta-, hexa-, or hepta-peptide or an acylated peptide thereof.
29. The composition of claim 19 , further comprising: hyaluronic acid, panthenol, panthetine, spironolactone, peptide, and glucosamine or glycosamineglycan.
30. The composition of claim 19 , wherein the concentration of the Type-F prostaglandin analogue is about 0.001-0.5% by weight of the total composition.
31. The composition of claim 1 , wherein the Type-F prostaglandin analogue is bimatoprost at a concentration of about 0.01-0.1% by weight of the total composition.
32. A method for promoting hair growth in a human subject, comprising:
topically applying an effective amount of the composition of claim 1 or 19 to the body of the subject such that the length of the hair is grown at least about 10% longer than that before the initial application of the inventive composition.
33. The method of claim 32 , wherein the hair is hair on the scalp, eyelashes, eyebrows, mustache or beard of the subject.
34. The method of claim 32 , wherein the hair is grown at least about 50% longer than that before the initial application of the inventive composition.
35. The method of claim 32 , wherein the density of the hair is increased at least about 10% than that before the initial application of the inventive composition.
36. The method of claim 32 , wherein the composition is applied to the subject per day at least 3 days a week.
37. The method of claim 32 , wherein the composition is applied to the root area of the eyelashes of the subject.
38. The method of claim 32 , wherein the composition is applied to the scalp of the subject.
39. A method for preventing or inhibiting hair loss in a human subject, comprising: topically applying an effective amount of the composition of claim 1 or 19 to the body of the subject.
40. The method of claim 39 , wherein the hair is hair on the scalp, eyelashes, eyebrows, mustache or beard of the subject.
41. A method for preventing or inhibiting hair miniaturization in a human subject, comprising: topically applying an effective amount of the composition of claim 1 or 19 to the body of the subject.
42. The method of claim 41 , wherein the hair is hair on the scalp, eyelashes, eyebrows, mustache or beard of the subject.
43. A method for treating alopecia or baldness in a human subject, comprising: topically applying an effective amount of the composition of claim 1 or 19 to the body of the subject.
44. The method of claim 43 , wherein the composition is applied to the scalp, the root area of the eyelashes, eyebrows, mustache or beard of the subject.
45. The method of claim 43 , wherein the alopecia or baldness is due to aging, chemotherapy, hormone, or environmental reasons.
46. A method for restructuring and/or increasing the volume of the hair shaft in a human subject, comprising: topically applying an effective amount of the composition of claim 1 or 19 to the body of the subject, such that the volume of the hair shaft is increased at least about 10% compared to that before the initial application of the inventive composition.
47. The method of claim 46 , wherein the cross-sectional diameter of the hair shaft is increased at least about 10% compared to that before the initial application of the inventive composition.
48. The method of claim 46 , wherein the hair is hair on the scalp, eyelashes, eyebrows, mustache or beard of the subject.
49. The method of claim 46 , wherein the composition is applied to the subject per day at least 3 days a week.
50. A method for enhancing pigmentation of the hair in a human subject, comprising: topically applying an effective amount of the composition of claim 1 or 19 to the body of the subject such that the pigmentation of the hair is increased at least about 10% compared to that of the natural hair of the subject.
51. The method of claim 50 , wherein the hair is hair on the scalp, eyelashes, eyebrows, mustache or beard of the subject.
52. A kit, comprising: a vessel containing the composition of claim 1 or 19 .
53. The kit of claim 52 , further comprising: a printed instruction for how to use the composition.
54. The kit of claim 53 , wherein the instruction includes instruction for how to topically apply the composition to the body of a human subject.
55. The kit of claim 54 , wherein the instruction for how to topically apply the composition to the body of a human subject includes instruction for how to apply to the scalp, the root area of the eyelashes, eyebrows, mustache or beard of the subject.
56. The kit of claim 52 , further comprising: an applicator for applying the composition to a human body.
57. The kit of claim 52 , wherein the vessel contains mascara which includes the composition.
58. A method for manufacturing a topical composition, comprising:
dissolving a compound of Formula I having the structure of
in propylene glycol, wherein X is O, S, or CH 2 ; and R 1 is methyl, ethyl, propyl or iso-propyl; and mixing the solution of the compound with at least one physiologically acceptable excipient.
59. The method of claim 58 , further comprising:
dissolving spironolactone in butylene glycol; and
mixing the solution of spironolactone with the solution of the compound.
60. The method of claim 58 , further comprising:
mixing the solution of the compound with hyaluronic acid, panthenol, panthetine, spironolactone, peptide, glucosamine or glycosamineglycan.