Administration of compstatin to an individual for the treatment of a tumor
View Patent ↗Methods for treating, preventing or delaying onset of tumor formation and other forms of cancer are disclosed. The methods involve administration of a complement inhibitor to inhibit C5a receptor signaling in the tumor microenvironment.
1. A method for treating an individual having a tumor, the method comprising the steps of:
(1) providing an individual having a tumor;
(2) administering to the individual a therapeutically effective amount of a complement inhibitor comprising a pharmaceutically acceptable carrier and at least one polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:2 and SEQ ID NO:3; and
(3) measuring the size of the tumor in the individual;
wherein the administering of the complement inhibitor results in a reduction in tumor size, or a delay or prevention of increase in tumor size, thereby treating the individual having the tumor.
2. The method of claim 1 wherein the individual is human.
3. The method of claim 1 , wherein the complement inhibitor is administered at or targeted to the site of the tumor.
4. The method of claim 1 , wherein the complement inhibitor is administered systemically.
5. The method of claim 1 , wherein the complement inhibitor is administered together or concurrently with, or sequentially before or after, at least one other anti-cancer treatment.
6. The method of claim 1 , wherein tumor size is measured by one or more of length, width, depth, volume and weight of the tumor.
7. A method of reducing or delaying growth or development of a tumor disposed within an individual, comprising the steps of:
(1) providing the individual in which a tumor is disposed;
(2) administering to the individual a therapeutically effective amount of a complement inhibitor comprising a pharmaceutically acceptable carrier and at least one polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:2 and SEQ ID NO:3; and
(3) measuring the size of the tumor;
wherein a reduction in tumor size, or a delay or prevention of increase in tumor size, is indicative of reducing or delaying the growth or development of the tumor disposed within the individual.
8. The method of claim 7 , wherein the individual is human.
9. The method of claim 7 , wherein the complement inhibitor is administered at or targeted to the site of the tumor.
10. The method of claim 7 , wherein the complement inhibitor is administered systemically.
11. The method of claim 7 , wherein the complement inhibitor is administered together or concurrently with, or sequentially before or after, at least one other anti-cancer treatment.
12. The method of claim 7 , wherein tumor size is measured by one or more of length, width, depth, volume and weight of the tumor.