Method for modulating or controlling sodium channel current by reactive oxygen species (ROS) originating from mitochondria
Method for modulating or controlling sodium channel current of a cell includes inducing mitochondrial reactive oxygen species (ROS) production in the cell.
1. A method of reducing arrhythmic risk in an individual with elevated intracellular NADH level, comprising the steps of:
a) providing an individual with elevated intracellular NADH level;
b) lowering the intracellular NADH level to a predetermined normal level by administering to the individual a therapeutic amount of a mitochondrial targeted antioxidant; and
c) wherein achieving the normal intracellular NADH level reduces arrhythmic risk in the individual.
2. The method of claim 1 , wherein the amount of antioxidant is effective to reduce arrhythmic risk.
3. The method of claim 1 , wherein the antioxidant prevents reduction in sodium channel current (I Na ) by reducing or suppressing mitochondrial ROS production.
4. The method of claim 1 , wherein the antioxidant is administered orally or intravenously.
5. The method of claim 1 , wherein the individual is suffering from arrhythmia.
6. The method of claim 1 , wherein the antioxidant comprises at least one member selected from the group consisting of a powder, a tablet, a capsule, a solution, a suspension, and an injectable formulation.
7. The method of claim 1 , wherein the antioxidant prevents a change in sodium channel current (I Na ) by reducing or suppressing mitochondrial ROS production.