REINFORCED TISSUE GRAFT
A biocompatible tissue graft is provided. The tissue graft includes an extracellular matrix patch and a means for reinforcing the patch.
1 . A biocompatible tissue graft comprising:
an extracellular matrix patch; and
a means for reinforcing the patch to mitigate tearing and/or improve fixation retention of the patch, wherein the reinforcing means comprises at least one fiber stitched into the patch in a reinforcement pattern.
2 . (canceled)
3 . The tissue graft of claim 1 , wherein the reinforcing means comprises fibers stitched into the patch in a concentric pattern.
4 . The tissue graft of claim 3 , wherein the reinforcing means comprises multiple concentric patterns of fibers stitched into the patch.
5 . The tissue graft of claim 1 , wherein the reinforcing means comprises fibers stitched into the patch in a cross-hatched configuration.
6 . The tissue graft of claim 1 , wherein the fiber is selected from the group consisting of silk, sericin free silk, modified silk fibroins, polyesters like polyglycolic acid (PGA), polylactic acid (PLA), polylactic-co-glycolic acid (PLGA), polyethyleneglycol (PEG), polyhydroxyalkanoates (PHA), polyethylene terephthalate (PET), polyethylene (PE), ultra-high molecular weight polyethylene (UHMWPE), blends thereof, and copolymers thereof.
7 . The tissue graft of claim 1 , wherein at least one of the patch and the fiber is modified to improve adhesion between the patch and the fiber.
8 . The tissue graft of claim 1 , wherein the patch is decellularized.
9 . The tissue graft of claim 1 , wherein the patch further comprises at least one progenitor cell.
10 . The tissue graft of claim 1 , wherein the patch further comprises at least one biologically active molecule selected from the group consisting of enzymes, hormones, cytokines, colony-stimulating factors, vaccine antigens, antibodies, clotting factors, angiogenesis factors, regulatory proteins, transcription factors, receptors, and structural proteins and combinations thereof.
11 . A biocompatible tissue graft comprising:
a fascia patch; and
at least one fiber stitched into the patch in a reinforcement pattern to mitigate tearing and/or improve fixation retention of the patch.
12 . The tissue graft of claim 11 , wherein the reinforcing means comprises fibers stitched into the patch in a concentric pattern.
13 . The tissue graft of claim 12 , wherein the reinforcing means comprises multiple concentric patterns of fibers stitched into the patch.
14 . The tissue graft of claim 11 , wherein the reinforcing means comprises fibers stitched into the patch in a cross-hatched configuration.
15 . The tissue graft of claim 11 , wherein the fiber is selected from the group consisting of silk, sericin free silk, modified silk fibroins, polyesters like polyglycolic acid (PGA), polylactic acid (PLA), polylactic-co-glycolic acid (PLGA), polyethyleneglycol (PEG), polyhydroxyalkanoates (PHA), polyethylene terephthalate (PET), polyethylene (PE), ultra-high molecular weight polyethylene (UHMWPE), blends thereof, and copolymers thereof.
16 . The tissue graft of claim 11 , wherein at least one of the patch and the fiber is modified to improve adhesion between the patch and the fiber.
17 . The tissue graft of claim 11 , wherein the patch is decellularized.
18 . The tissue graft of claim 11 , wherein the patch further comprises at least one progenitor cell.
19 . The tissue graft of claim 11 , wherein the patch further comprises at least one biologically active molecule selected from the group consisting of enzymes, hormones, cytokines, colony-stimulating factors, vaccine antigens, antibodies, clotting factors, angiogenesis factors, regulatory proteins, transcription factors, receptors, and structural proteins.
20 - 29 . (canceled)
30 . A method for repairing tissue in a subject comprising:
administering to the tissue a tissue graft comprising an extracellular matrix patch and at least one fiber stitched into the patch to mitigate tearing and/or improve fixation retention of the patch.
31 . The method of claim 30 , wherein the step of administering the tissue graft comprises securing the tissue graft in or on recipient tissue.
32 . The method of claim 31 , wherein the step of securing the tissue graft in or on recipient tissue comprises suturing, stitching, or screwing.