Growth factor-mimicking peptides and uses thereof
The present invention relates to a growth factor-mimicking peptide having an activity of the growth factor, and a composition and a method for improving skin conditions or for treating a wound using the same. The growth factor-mimicking peptides of this invention have identical functions or actions to natural-occurring human growth factor, and much better stability and skin penetration potency than natural-occurring growth factor. In these connections, the composition comprising the peptides of this invention can exhibit excellent efficacies on the treatment, prevention and improvement of diseases or conditions demanding growth factor activities. In addition, excellent activity and stability of the peptides of this invention can be advantageously applied to pharmaceutical compositions, quasi-drugs and cosmetics.
1. A method for improving skin conditions, comprising administering to a subject a composition containing as an active ingredient a peptide comprising the amino acid sequence of SEQ ID NO:1.
2. The method according to claim 1 , wherein the C-terminal of the peptide is modified to have a hydroxyl group (—OH) or an amino group (—NH 2 ).
3. The method according to claim 1 , wherein the N-terminal of the peptide is protected with a protection group selected from the group consisting of acetyl group, fluorenyl methoxy carbonyl group, formyl group, palmitoyl group, myristyl group, stearyl group, and polyethylene glycol (PEG).
4. The method according to claim 1 , wherein the improvement in the skin condition is improvement in wrinkle or skin elasticity, prevention of skin aging, prevention of hair loss, promotion of hair growth, improvement in skin moisture, the removal of dark spots, the treatment of acne, or wound healing.