Kinase inhibitors

1. A compound of Formula (I):

wherein:

X is CH or N;

R 1 is selected from H, halo, CN, C 1 -C 10 alkyl or halo(C 1 -C 4 )alkyl, wherein C 1 -C 10 alkyl, or halo(C 1 -C 4 )alkyl is optionally substituted;

R 2 is aryl, cycloalkyl, arylalkyl, or heterocyclyl, wherein the aryl, cycloalkyl, arylalkyl, or heterocyclyl is optionally and independently substituted at one or more carbon atoms with 1-4 R 5 or R 5a groups; and wherein aryl and heterocyclyl having one or more nitrogen atoms is optionally and independently substituted at one or more nitrogen atoms with 1-4 R 6 or R 6a groups;

R 3 is independently halo, CN, or R 7 ; and

R 4 is selected from (CH 2 ) n OH, (CH 2 ) n NR 11 R 12 , C(O)NHR 7 , C(O)NR 11 R 12 , C(O)R 7 , C(O)NR 7 R 7 , C(O)NR 7 R 8 , (CH 2 ) n NR 7 R 7 , (CH 2 ) n NR 7 R 8 , (CH 2 ) n CN, (CH 2 ) n SR 7 , (CH 2 ) n S(O) n R 7 , or (CH 2 ) n S(O) n NR 7 R 7 , wherein each n is independently 1 or 2;

wherein:

Each R 5 is independently selected from halo, CF 3 , SR 7 , OR 7 , OC(O)R 7 , O(CH 2 ) n NR 7 R 7 , O(CH 2 ) n NR 11 R 12 , O(CH 2 ) n R 7 , O(CH 2 ) n C(O)NR 11 R 12 , O(CH 2 ) n C(O)NR 7 R 7 , NR 7 R 7 , NR 7 R 8 , NHC(O)NH 2 , C(O)OR 7 , NO 2 , CN, C(O)R 7 , OSO 2 CH 3 , S(O) n R 7 , S(O) n NR 7 R 7 , NR 7 C(O)NR 7 R 7 , NR 7 C(O)R 7 , NR 7 C(O)OR 7 , NR 7 S(O) n R 7 , or NR 11 R 12 , wherein each n is independently 1 or 2;

Each R 5a is independently selected from amino, halo, hydroxy, C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 3 -C 10 alkynyl, C 3 -C 12 cycloalkyl, C 5 -C 10 cycloalkenyl, alkoxy, haloalkyl, aryl, heteroaryl, or heterocyclyl, wherein the C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 3 -C 10 alkynyl, C 3 -C 12 cycloalkyl, C 5 -C 10 cycloalkenyl, alkoxy, haloalkyl, aryl, heteroaryl, or heterocyclyl is optionally and independently substituted with 1 to 3 groups selected from halo, hydroxy, alkyl, R 9 , or R 10 ;

Each R 6 is independently R 7 , C(O)CH 2 CN, C(O)R 7 , C(O)OR 7 , CO 2 (C 1 -C 6 alkyl), C(O)NR 7 R 7 , SO 2 NR 7 R 7 , or SO 2 R 7 ;

Each R 6a is independently hydroxy, C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 3 -C 10 alkynyl, C 3 -C 12 cycloalkyl, C 5 -C 10 cycloalkenyl, haloalkyl, wherein each R 6a group is optionally and independently substituted with 1-3 groups selected from hydroxy, aryl, alkyl, halo, R 9 , or R 10 ;

Each R 7 is independently H, C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 3 -C 10 alkynyl, C 3 -C 12 cycloalkyl, C 5 -C 12 cycloalkenyl, aryl, aryl(C 1 -C 4 )alkyl, haloalkyl, heteroaryl, or heterocyclyl, wherein the C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 3 -C 10 alkynyl, C 3 -C 12 cycloalkyl, C 5 -C 12 cycloalkenyl, aryl, aryl(C 1 -C 4 )alkyl, haloalkyl, heteroaryl, or heterocyclyl is optionally and independently substituted with 1-4 groups selected from aryl, cycloalkyl, heteroaryl, heterocyclyl, alkyl, halo, amino, hydroxy, R 9 , or R 10 ;

Each R 8 is independently C(O)R 7 , C(O)OR 7 , C(O)NR 7 R 7 , or S(O) n R 7 , wherein n is 1 or 2;

Each R 9 is independently CF 3 , SR 7 , OR 7 , NR 7 R 7 , NR 11 R 12 , C(O)NR 7 R 7 , C(O)NR 11 R 12 , S(O) n NR 7 R 7 , or S(O) n R 7 , wherein each n is independently 1 or 2;

Each R 10 is C(O)O(C 1 -C 6 )alkyl, or halo(C 1 -C 4 )alkyl; and

R 11 and R 12 , taken together with the nitrogen atom to which they are bonded form:

i) a 3-8 membered saturated or partially saturated ring having no heteroatom other than the nitrogen atom to which R 11 and R 12 are bonded, wherein said 3-8 membered saturated or partially saturated ring is optionally and independently substituted with 1-4 groups selected from R 5 or R 5a at one or more substitutable carbon atoms;

ii) a 5-8 membered saturated or partially saturated ring having 1-3 heteroatoms, in addition to the nitrogen atom to which R 11 and R 12 are bonded, wherein said 1-3 heteroatoms are independently selected from nitrogen, oxygen, sulfur, sulfone or sulfoxide, and wherein said 5-8 membered saturated or partially saturated ring having 1-3 heteroatoms is optionally and independently substituted with 1-4 groups selected from R 5 or R 5a at one or more substitutable carbon atoms and at one or more substitutable nitrogen atoms with R 6 or R 6a ;

iii) a 9-10 membered saturated or partially saturated bicyclic ring having no heteroatom other than the nitrogen atom to which R 11 and R 12 are bonded, wherein said 9-10 membered saturated or partially saturated bicyclic ring having no heteroatom is optionally substituted with 1-4 groups independently selected from R 5 or R 5a at one or more substitutable carbon atoms;

iv) a 9-10 membered saturated or partially saturated bicyclic ring having 1-5 heteroatoms, in addition to the nitrogen atom to which R 11 and R 12 are bonded, wherein said heteroatoms are independently selected from nitrogen, oxygen, sulfur, sulfoxide, sulfone, carboxamide or sulfoxamide; or

v) a 6-14 membered saturated or partially saturated bridged ring having 1-3 heteroatoms in addition to the nitrogen atom to which R 11 and R 12 are bonded, wherein said 1-3 heteroatoms are independently selected from nitrogen, oxygen, sulfur, sulfone, or sulfoxide, and wherein said 6-14 membered saturated or partially saturated bridged ring having 1-3 heteroatoms is optionally and independently substituted with 1-4 groups selected from R 5 or R 5a at one or more substitutable carbon atoms and at one or more substitutable nitrogen atoms with R 6 or R 6a ;

or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 , wherein R 2 is an aryl selected from: a 5-6 membered monocyclic aryl group having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; an 8-10 membered bicyclic aryl group having 0-5 heteroatoms independently selected from nitrogen, oxygen, sulfur, sulfoxide, or sulfone; an 8-10 membered partially saturated bicyclic aryl group having 0-5 heteroatoms independently selected from nitrogen, oxygen, sulfur, sulfoxide, or sulfone; or an 8-10 membered partially saturated bicyclic aryl group having a carboxamide or sulfoxamide.

3. The compound of claim 2 , wherein R 2 is a 5-6 membered monocyclic aryl having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur optionally and independently substituted with 1-4 R 5 or R 5a groups.

4. The compound of claim 3 , wherein the 5-6 membered monocyclic aryl is phenyl or pyrimidinyl optionally and independently substituted with 1, 2, or 3 groups selected from methyl, ethyl, phenyl, isoprophyl, methoxy, hydroxyethoxy, CF 3 , OC 6 H 5 , OCH 2 CH 2 NR 11 R 12 , OCH 2 CH 2 NR 7 R 7 , OCH 2 C 6 H 5 , OCH 2 C(O)NR 11 R 12 , OCH 2 C(O)NR 7 R 7 , OSO 2 CH 3 , SO 2 CH 3 , SO 2 NHCH 3 , or NR 11 R 12 .

5. The compound of claim 1 , wherein R 4 is (CH 2 ) n NR 11 R 12 , and R 11 and R 12 , taken together with the nitrogen atom to which they are bonded form:

i) a 3-8 membered saturated or partially saturated ring having no heteroatom other than the nitrogen atom to which R 11 and R 12 are bonded, wherein said 3-8 membered saturated or partially saturated ring is optionally and independently substituted with 1-4 groups selected from R 5 or R 5a at one or more substitutable carbon atoms;

ii) a 5-8 membered saturated or partially saturated ring having 1-3 heteroatoms, in addition to the nitrogen atom to which R 11 and R 12 are bonded, wherein said 1-3 heteroatoms are independently selected from nitrogen, oxygen, sulfur, sulfone or sulfoxide, and wherein said 5-8 membered saturated or partially saturated ring having 1-3 heteroatoms is optionally and independently substituted with 1-4 groups selected from R 5 or R 5a at one or more substitutable carbon atoms and at one or more substitutable nitrogen atoms with R 6 or R 6a ;

iii) a 9-10 membered saturated or partially saturated bicyclic ring having no heteroatom other than the nitrogen atom to which R 11 and R 12 are bonded, wherein said 9-10 membered saturated or partially saturated bicyclic ring having no heteroatom is optionally substituted with 1-4 groups independently selected from R 5 or R 5a at one or more substitutable carbon atoms;

iv) a 9-10 membered saturated or partially saturated bicyclic ring having 1-5 heteroatoms, in addition to the nitrogen atom to which R 11 and R 12 are bonded, wherein said heteroatoms are independently selected from nitrogen, oxygen, sulfur, sulfoxide, sulfone, carboxamide or sulfoxamide; or

v) a 6-14 membered saturated or partially saturated bridged ring having 1-3 heteroatoms in addition to the nitrogen atom to which R 11 and R 12 are bonded, wherein said 1-3 heteroatoms are independently selected from nitrogen, oxygen, sulfur, sulfone, or sulfoxide, and wherein said 6-14 membered saturated or partially saturated bridged ring having 1-3 heteroatoms is optionally and independently substituted with 1-4 groups selected from R 5 or R 5a at one or more substitutable carbon atoms and at one or more substitutable nitrogen atoms with R 6 or R 6a .

6. The compound of claim 5 , wherein R 11 and R 12 , taken together with the nitrogen atom to which they are bonded form a 3-8 membered saturated or partially saturated ring having no heteroatom other than the nitrogen atom to which R 11 and R 12 are bonded, wherein said 3-8 membered ring is optionally and independently substituted with 1-4 groups selected from R 5 or R 5a at one or more substitutable carbon atoms.

7. The compound of claim 6 , wherein the 3-8 membered saturated or partially saturated ring is a 4-6 membered ring selected from azetidinyl, pyrrolidinyl, or piperidinyl optionally and independently substituted with 1-2 groups selected from hydroxy, halo, OC(O)R 7 , CH 2 OH, CH 2 CH 2 OH, NH 2 , NR 7 R 7 , NHC(O)NHR 7 , NHSO 2 R 7 , C(O)OR 7 , or C(O)NHR 7 at one or more substitutable carbon atoms.

8. A compound selected from:

methyl 1-(5-methyl-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-yl)-1H-pyrrole-3-carboxylate;

ethyl 1-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-3-methyl-1H-pyrazole-4-carboxylate;

1-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-3-methyl-1H-pyrazole-4-carboxylic acid;

(1-(2-(3,5-dimethylphenylamino)-5-fluoropyrimidin-4-yl)-3-methyl-1H-pyrazol-4-yl)methanol;

(1-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-3-methyl-1H-pyrazol-4-yl)methanol;

(1-(2-(3,5-dimethylphenylamino)-5-fluoropyrimidin-4-yl)-1H-pyrazol-4-yl)methanol;

(1-(2-(3,5-dimethoxyphenylamino)-5-fluoro pyrimidin-4-yl)-1H-pyrazol-4-yl)methanol;

(1-(2-(3,5-dimethoxyphenylamino)-5-fluoropyrimidin-4-yl)-3-methyl-1H-pyrazol-4-yl)methanol;

(1-(2-(3,5-dimethyl phenylamino)pyrimidin-4-yl)-1H-pyrrol-3-yl)methanol;

(1-(2-(2,3-dihydro-1H-inden-5-ylamino)pyrimidin-4-yl)-1H-pyrrol-3-yl)methanol;

(1-(2-(3,5-dimethyl-4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methanol;

(1-(2-(3,5-dimethyl-4-phenoxyphenylamino)pyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methanol;

(1-(2-(3,5-dimethylphenylamino)-5-fluoropyrimidin-4-yl)-1H-pyrrol-3-yl)methanol;

(1-(2-(3,5-dimethylphenylamino)-5-fluoropyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methanol;

2-(4-(5-fluoro-4-(3-(hydroxymethyl)-4-methyl-1H-pyrrol-1-yl)pyrimidin-2-ylamino)-2,6-dimethylphenoxy)ethanol;

(1-(2-(3,5-dimethoxyphenylamino)-5-fluoropyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methanol;

(1-(2-(3,5-bis(trifluoromethyl)phenylamino)-5-fluoropyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methanol;

(1-(5-fluoro-2-(naphthalene-2-ylamino)pyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methanol;

(1-(5-chloro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methanol;

(4-cyclopropyl-1-(5- methyl-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-yl)-1H-pyrrol-3-yl)methanol;

(4-methyl-1-(5-methyl-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-yl)-1H-pyrrol-3-yl)methanol;

2-(4-(4-(3-(hydroxyl methyl)-4-methyl-1H-pyrrol-1-yl)-5-methyl pyrimidin-2-ylamino)-2,6-dimethoxyphenoxy)ethanol;

2-(4-(4-(4-(3-(hydroxylmethyl)-4-methyl-1H-pyrrol-1-yl)-5-methyl pyrimidin-2-ylamino)-2-methylphenyl)piperazin-1-yl)ethanol;

(S)-1-(4-(4-(3-(hydroxylmethyl)-4-methyl-1H-pyrrol-1-yl)-5-methyl pyrimidin-2-ylamino)-2-methylphenyl)pyrrolidin-3-ol;

(1-(5-fluoro-2-(4-(methylsulfonyl)phenylamino)pyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methanol;

(1-(2-(3,5-dimethylphenylamino)-5-(trifluoromethyl)pyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methanol;

(1-(2-(3,5-dimethylphenylamino)-5-fluoropyrimidin-4-yl)-4-phenyl-1H-pyrrol-3-yl)methanol;

(1-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-yl)-4-(furan-3-yl)-1H-pyrrol-3-yl)methanol;

1-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-N-(2-hydroxyethyl)-N,3-dimethyl-1H-pyrazole-4-carboxamide;

1-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-N,N-bis(2-hydroxyethyl)-3-methyl-1H-pyrazole-4-carboxamide;

(S)-(1-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-3-methyl-1H-pyrazol-4-yl)(3-hydroxypyrrolidin-1-yl)methanone;

(R)-(1-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-3-methyl-1H-pyrazol-4-yl)(3-hydroxypyrrolidin-1-yl)methanone;

N-(2-aminoethyl)-1-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide;

1-(2-(3,5-dimethoxyphenylamino)-5-fluoropyrimidin-4-yl)-N-(3,5-dimethyl phenyl)-1H-pyrazole-4-carboxamide;

(1-(2-(3,5-dimethoxyphenylamino)-5-fluoropyrimidin-4-yl)-1H-pyrazol-4-yl)(piperidin-1-yl)methanone;

(S)-1-(2-(3,5-dimethoxyphenylamino)-5-fluoropyrimidin-4-yl)-N-(1-hydroxy propan-2-yl)-3-methyl-1H-pyrazole-4-carboxamide;

N-benzyl-1-(2-(3,5-dimethoxyphenylamino)-5-fluoropyrimidin-4-yl)-1H-pyrazole-4-carboxamide;

(R)-(1-(2-(3,5-dimethylphenylamino)-5-fluoropyrimidin-4-yl)-3-methyl-1H-pyrazol-4-yl)(3-hydroxypyrrolidin-1-yl)methanone;

2-((1-(2-(3,5-dimethylphenylamino)-5-fluoropyrimidin-4-yl)-3-methyl-1H-pyrazol-4-yl)methylamino)ethanol;

2-(4-((4-methyl-1-(5-methyl-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-yl)-1H-pyrrol-3-yl)methyl)piperazin-1-yl)ethanol;

(R)-1-((1-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methyl)pyrrolidin-3-ol;

1-((4-cyclopropyl-1-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-1H-pyrrol-3-yl)methyl)azetidin-3-ol;

4-(4-((benzylamino)methyl)-3-methyl-1H-pyrazol-1-yl)-N-(3,5-dimethylphenyl)pyrimidin-2-amine;

4-(4-(3-((3-hydroxyazetidin-1-yl)methyl)-4-methyl-1H-pyrrol-1-yl)pyrimidin-2-ylamino)-2,6-dimethylphenyl methanesulfonate;

(R)-4-(4-(3-((3-hydroxypyrrolidin-1-yl)methyl)-4-methyl-1H-pyrrol-1-yl)pyrimidin-2-ylamino)-N,2-dimethylbenzenesulfonamide;

(R)-1-((1-(2-(3,5-dimethyl-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl amino)pyrimidin-4-yl)-3-methyl-1H-pyrazol-4-yl)methyl)pyrrolidin-3-ol;

(S)-1-((1-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methyl)pyrrolidine-3-carboxylic acid;

(R)-1-((1-(2-(3,5-dimethyl-4-phenoxyphenylamino)pyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methyl)pyrrolidin-3-ol;

(R)-1-(1-((1-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methyl)pyrrolidin-3-yl)urea;

1-((4-methyl-1-(2-(2-methylbiphenyl-4-ylamino)pyrimidin-4-yl)-1H-pyrrol-3-yl)methyl)azetidin-3-ol;

1-((1-(2-(2,3-dihydro-1H-inden-5-ylamino)pyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methyl)azetidin-3-ol1-((4-methyl-1-(2-(1-methyl-1H-indo1-5-ylamino)pyrimidin-4-yl)-1H-pyrrol-3-yl)methyl)azetidin-3-ol;

(R)-1-((4-methyl-1-(2-(1-methyl-1H-indo-5-ylamino)pyrimidin-4-yl)-1H-pyrrol-3-yl)methyl) pyrrolidin-3-ol;

4-(3-((4,4-difluoropiperidin-1-yl)methyl)-4-methyl-1H-pyrrol-1-yl)-N-(3,5-dimethylphenyl)pyrimidin-2-amine;

(R)-2-(4-(4-(4-((3-hydroxypyrrolidin-1-yl)methyl)-3-methyl-1H-pyrazol-1-yl)pyrimidin-2-ylamino)-2,6-dimethylphenoxy)-1-morpholinoethanone;

2-(4-(4-(4-((3-hydroxyazetidin-1-yl)methyl)-3-methyl-1H-pyrazol-1-yl)pyrimidin-2-ylamino)-2,6-dimethylphenoxy)-1-morpholinoethanone;

N-(3,5-dimethylphenyl)-5-fluoro-4-(3-methyl-4-(pyrrolidin-1-ylmethyl)-1H-pyrazol-1-yl)pyrimidin-2-amine;

N-(3,5-dimethylphenyl)-5-fluoro-4-(3-methyl-4-(pyrrolidin-1-ylmethyl)-1H-pyrazol-1-yl)pyrimidin-2-amine;

(S)-2-((1-(2-(3,5-dimethylphenylamino)-5-fluoropyrimidin-4-yl)-3-methyl-1H-pyrazol-4-yl)methyl amino)propan-1-ol;

4-(4-((cyclopropylamino)methyl)-3-methyl-1H-pyrazol-1-yl)-N-(3,5-dimethylphenyl)-5-fluoropyrimidin-2-amine;

4-(4-((cyclohexylamino)methyl)-3-methyl-pyrazol-1-yl)-N-(3,5-dimethylphenyl)-5-fluoropyrimidin-2-amine;

N-(3,5-dimethylphenyl)-5-fluoro-4-(3-methyl-4-(piperidin-1-ylmethyl)-1H-1-pyrazol-1-yl)pyrimidin-2-amine;

N-(3,5-dimethylphenyl)-5-fluoro-4-(3-methyl-4-(morpholinomethyl)-1H-pyrazol-1-yl)pyrimidin-2-amine;

N-(3,5-dimethylphenyl)-5-fluoro-4-(3-methyl-4-((phenylamino)methyl)-1H-pyrazol-1-yl)pyrimidin-2-amine;

4-(4-((3,4-dihydroisoquinolin-2(1H)-yl)methyl)-3-methyl-1H-pyrazol-1-yl)-N-(3,5-dimethyl phenyl)-5-fluoropyrimidin-2-amine;

4-(4-((benzyl(methyl)amino)methyl)-3-methyl-1H-pyrazol-1-yl)-N-(3,5-dimethylphenyl)-5-fluoro pyrimidin-2-amine;

N 1 -((1-(2-(3,5-dimethylphenylamino)-5-fluoropyrimidin-4-yl)-3-methyl-1H-pyrazol-4-yl)methyl)ethane-1,2-diamine;

N-(3,5-dimethylphenyl)-5-fluoro-4-(4-((4-fluorophenethylamino)methyl)-3-methyl-1-pyrazol-1-yl)pyrimidin-2-amine;

N-(3,5-dimethylphenyl)-5-fluoro-4-(3-methyl-4-((pyridin-4-ylmethylamino)methyl)-1H-pyrazol-1-yl)pyrimidin-2-amine;

(S)-1-((1-(2-(3,5-dimethylphenylamino)-5-fluoropyrimidin-4-yl)-3-methyl-1H-pyrazol-4-yl)methyl)pyrrolidin-3-ol;

(R)-1-((1-(2-(3,5-dimethylphenylamino)-5-fluoropyrimidin-4-yl)-3-methyl-1H-pyrazol-4-yl)methyl)pyrrolidin-3-ol;

1-((1-(2-(3,5-dimethylphenylamino)-5-fluoropyrimidin-4-yl)-3-methyl-1H-1-pyrazol-4-yl)methyl)piperidin-4-ol;

N-(3,5-dimethylphenyl)-5-fluoro-4-(3-methyl-4-(piperidin-1-ylmethyl)-1H-pyrrol-1-yl)pyrimidin-2-amine;

1-((3-methyl-1-(5-methyl-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-yl)-1H-pyrazol-4-yl)methyl)azetidin-3-ol;

2-((1-(2-(3,5-dimethylphenylamino)-5-fluoropyrimidin-4-yl)-3-methyl-1H-pyrazol-4-yl)methyl amino)ethanol;

4-(4-((benzylamino)methyl)-3-methyl-1H-pyrazol-1-yl)-N-(3,5-dimethylphenyl)-5-fluoropyrimidin-2-amine;

N-(3,5-dimethylphenyl)-5-fluoro-4-(3-methyl-4-((4-methylpiperazin-1-yl)methyl)-1H-pyrazol-1-yl)pyrimidin-2-amine;

4-(4-((dimethylamino)methyl)-3-methyl-1H-pyrazol-1-yl)-N-(3,5-dimethylphenyl)-5-fluoropyrimidin-2-amine;

N-(3,5-dimethylphenyl)-5-fluoro-4-(3-methyl-4-((piperidin-4-ylamino) methyl)-1H-pyrazol-1-yl)pyrimidin-2-amine trihydrochloride;

N-(3,5-dimethylphenyl)-5-fluoro-4-(3-(3-sulfonylpyrrolidin-1-ylmethyl)-1H-pyrrol-1-yl)pyrimidin-2-amine;

4-(3-((dimethylamino)methyl)-4-methyl-1H-pyrrol-1-yl)-N-(3,5-dimethylphenyl)-5-fluoropyrimidin-2-amine;

N-(3,5-dimethylphenyl)-5-fluoro-4-(3-methyl-4-(morpholinomethyl)-1H-pyrrol-1-yl)pyrimidin-2-amine;

(R)-1-((1-(2-(3,5-dimethylphenylamino)-5-fluoropyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methyl) pyrrolidin-3-ol;

1-((1-(2-(3,4-dimethylphenylamino)-5-fluoropyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methyl)azetidin-3-ol;

(R)-2-(4-(5-fluoro-4-(3-((3-hydroxypyrrolidin-1-yl)methyl)-4-methyl-1H-pyrrol-1-yl)pyrimidin-2-ylamino)-2,6-dimethylphenoxy)-1-morpholinoethanone;

3-(4-((4-methyl-1-(5-methyl-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-yl)-1H-pyrrol-3-yl)methyl)piperazin-1-yl)-3-oxopropanenitrile;

(R)-4-(3-((3-aminopyrrolidin-1-yl)methyl)-4-methyl-1H-pyrrol-1-yl)-N-(3,5-dimethylphenyl)-5-fluoropyrimidin-2-amine;

1-((1-(5-fluoro-2-(naphthalen-2-ylamino)pyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methyl)azetidin-3-ol;

1-((1-(2-(4-(benzyloxy)-3,5-dimethoxyphenylamino)-5-methylpyrimidin-4-yl)-1H-pyrrol-3-yl)methyl)azetidin-3-ol;

(R)-4-(5-fluoro-4-(3-((3-hydroxypyrrolidin-1-yl)methyl)-4-methyl-1H-pyrrol-1-yl)pyrimidin-2-ylamino)-2,6-dimethylphenyl methanesulfonate;

(R)-1-((1-(5-fluoro-2-(4-(2-hydroxyethoxy)-3,5-dimethylphenylamino)pyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methyl)pyrrolidin-3-ol;

1-((4-methyl-1-(5-methyl-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-yl)-1H-pyrrol-3-yl)methyl)azetidin-3-ol;

1-((4-methyl-1-(5-methyl-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-yl)-1H-pyrrol-3-yl)methyl)azetidin-3-yl acetate;

1-((4-methyl-1-(5-methyl-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-yl)-1H-pyrrol-3-yl)methyl)azetidin-3-yl pivalate;

1-((4-cyclopropyl-1-(5-methyl-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-yl)-1H-pyrrol-3-yl)methyl)azetidin-3-ol;

1-((4-methyl-1-(5-methyl-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-yl)-1H-pyrrol-3-yl)methypurea;

4-(3-((1,4-diazepan-1-yl)methyl)-4-methyl-1H-pyrrol-1-yl)-5-methyl-N-(3,4,5-trimethoxyphenyl)pyrimidin-2-amine trihydrochloride;

(S)-1-((1-(2-(3,5-dimethylphenylamino)-5-fluoropyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methyl) pyrrolidin-3-ol;

2,2-dimethyl-1-(4-((4-methyl-1-(5-methyl-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-yl)-1H-pyrrol-3-yl)methyl)-1,4-diazepan-1-yl)propan-1-one;

(S)-1-((1-(2-(3,5-dimethylphenylamino)-5-fluoropyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methyl)pyrrolidin-3-ol;

1-((1-(2-(3,5-dimethylphenylamino)-5-fluoropyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methyl)piperidin-4-ol;

(S)-2-((1-(2-(3,5-dimethylphenylamino)-5-fluoropyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methylamino)propan-1-ol;

4-(3-((benzylamino)methyl)-4-methyl-1H-pyrrol-1-yl)-N-(3,5-dimethoxyphenyl)-5-fluoro pyrimidin-2-amine;

(R)-1-((1-(2-(3,5-dimethoxyphenylamino)-5-fluoropyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methyl)pyrrolidin-3-ol;

4-(3-((dimethylamino)methyl)-4-(furan-3-yl)-1H-pyrrol-1-yl)-5-fluoro-N-(3,4,5-trimethoxyphenyl)pyrimidin-2-amine;

1-((1-(2-(3,5-dimethoxyphenylamino)-5-fluoropyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methyl) piperidin-4-ol;

N-(3,5-dimethoxyphenyl)-4-(3-((dimethylamino)methyl)-4-methyl-1H-pyrrol-1-yl)-5-fluoropyrimidin-2-amine;

(R)-1-((1-(5-fluoro-2-(3-(trifluoromethyl)phenylamino)pyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methyl)pyrrolidin-3-ol;

1-((1-(5-fluoro-2-(3-(trifluoromethyl)phenylamino)pyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl) methyl)piperidin-4-ol;

2-(4-((1-(5-chloro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methyl)piperazin-1-yl)ethanol;

1-((1-(5-chloro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methypazetidin-3-ol;

1-((1-(5-chloro-2-(4-(2-hydroxyethoxy)-3,5-dimethylphenylamino)pyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methypazetidin-3-ol;

4-(3-((dimethylamino)methyl)-4-methyl-1H-pyrrol-1-yl)-N-(3,5-dimethylphenyl)-5-methylpyrimidin-2-amine;

4-(3-((dimethylamino)methyl)-4-methyl-1H-pyrrol-1-yl)-N-(3,5-dimethylphenyl)-5-methylpyrimidin-2-amine;

1-((1-(2-(3,5-dimethylphenylamino)-5-methylpyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methyl)piperidin-4-ol;

2-(4-((1-(2-(4-(4-(2-hydroxyethyl)piperazin-1-yl)-3-methylphenylamino)-5-methylpyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methyl)piperazin-1-ypethanol;

4-((1-(2-(4-(2-hydroxyethoxy)-3,5-dimethylphenylamino)-5-methylpyri midin-4-yl)-4-methyl-1H-pyrrol-3-yl)methyl)-N-methyl-1,4-diazepane-1-carboxamide;

4-((1-(2-(4-(2-hydroxyethoxy)-3,5-dimethylphenylamino)-5-methylpyri midin-4-yl)-4-methyl-1H-pyrrol-3-yl)methyl)-1,4-diazepane-1-carboxamide;

1-((4-methyl-1-(5-methyl-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-yl)-1H-pyrrol-3-yl)methyl)piperidin-4-ol;

(1-((4-methyl-1-(5-methyl-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-yl)-1H-pyrrol-3-yl)methyl)piperidin-4-yl)methanol;

1-((1-(2-(3,5-dimethyl-4-(2(pyrrolidin-1-ypethoxy)phenylamino)-5-methylpyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methyl) azetidin-3-ol;

2-(4-(4-(3-((dimethylamino)methyl)-4-methyl-1H-pyrrol-1-yl)-5-methylpyrimidin-2-ylamino)-2,6-dimethylphenoxy)ethanol;

(R)-1-((1-(5-fluoro-2-(4-(2-hydroxyethoxy)-3,5-dimethylphenylamino)pyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methyl)pyrrolidin-3-ol;

4-(3-((dimethylamino)methyl)-4-methyl-1H-pyrrol-1-yl)-5-fluoro-N-(3-(trifluoromethyl)phenyl) pyrimidin-2-amine;

2-(4-(5-fluoro-4-(3-((3-hydroxyazetidin-1-yl)methyl)-4-methyl-1H-pyrrol-1-yl)pyrimidin-2-ylamino)-2,6-dimethylphenoxy)-1-(pyrrolidin-1-yl)ethanone;

(R)-1-((1-(2-(3,5-dimethylphenyl amino)-5-(trifluoromethyl) pyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methyl)pyrrolidin-3-ol;

1-((1-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-yl)-4-(furan-3-yl)-1H-pyrrol-3-yl)methypazetidin-3-ol;

4-(3-((dimethylamino)methyl)-4-phenyl-1H-pyrrol-1-yl)-N-(3,5-dimethylphenyl)-5-fluoropyrimidin-2-amine;

(R)-1-((1-(2-(3,5-dimethylphenylamino)-5-fluoropyrimidin-4-yl)-4-phenyl-1H-pyrrol-3-yl)methyl)pyrrolidin-3-ol;

N-(3,5-bis(trifluoromethyl)phenyl)-4-(3-((dimethylamino)methyl)-4-methyl-1H-pyrrol-1-yl)-5-fluoropyrimidin-2-amine;

(R)-1-((1-(2-(3,5-bis(trifluoromethyl)phenylamino)-5-fluoropyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methyl)pyrrolidin-3-ol;

1-((1-(2-(3,5-bis(trifluoromethyl)phenylamino)-5-fluoropyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methyl)piperidin-4-ol;

4-(3-((dimethylamino)methyl)-1H-pyrrol-1-yl)-N-(3,5-dimethylphenyl)-5-fluoropyrimidin-2-amine;

(R)-1-((1-(2-(3,5-dimethylphenylamino)-5-fluoropyrimidin-4-yl)-1H-pyrrol-3-yl)methyl)pyrrolidin-3-ol;

4-(3-(2,5-diazabicyclo[2.2.1]heptan-2-ylmethyl)-4-methyl-1H-pyrrol-1-yl)-5-bromo-N-(3,4,5-trimethoxyphenyl)pyrimidin-2-amine trihydrochloride;

(R)-2-(4-(5-fluoro-4-(3-((3-hydroxypyrrolidin-1-yl)methyl)-4-methyl-1H-pyrrol-1-yl)pyrimidin-2-ylamino)-2,6-dimethylphenoxy)-1-morpholinoethanone;

2-(4-(4-(3-(2,5-diazabicyclo[2.2.1]heptan-2-ylmethyl)-4-methyl-1H-pyrrol-1-yl)-5-methylpyrimidin-2-ylamino)-2,6-dimethylphenoxy)ethanol trihydrochloride;

4-(3-((1,4-diazepan-1-yl)methyl)-4-methyl-1H-pyrrol-1-yl)-5-chloro-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)pyrimidin-2-amine;

1-((1-(5-chloro-2-(2,3-dihydrobenzo[b][1,4]dioxin-6-ylamino)pyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methyl)azetidin-3-ol; or

(R)-1-((1-(2-(4,6-dimethylpyrimidin-2-ylamino)-5-fluoropyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methyl)pyrrolidin-3-ol.

9. A pharmaceutical formulation comprising a compound of claim 1 in combination with a pharmaceutically acceptable carrier, diluent or excipient.

10. The compound of claim 1 , wherein X is CH.