Methods of treating infections originating from viruses in the herpesviridae family
Three RNases (ranpirnase, the second embodiment disclosed in U.S. Pat. No. 5,728,805, and recombinant Amphinase-2) are tested against identified herpesviridae infections. With some exceptions, quantitative PCR assays indicate that the RNases have anti-viral activity against many of these viruses.
1. A method of treating a herpesviridae infection that is other than roseolovirus-6A, comprising the step of administering to a living subject in need of such treatment a therapeutically effective amount of a polypeptide consisting of the amino acid sequence disclosed in FIG. 2 of U.S. Pat. No. 5,559,212.
2. A method of treating a herpesviridae infection that is other than roseolovirus-6A, comprising the step of administering to a living subject in need of such treatment a therapeutically effective amount of a polypeptide consisting of the amino acid sequence of SEQ ID NO:2 of U.S. Pat. No. 5,728,805.
3. A method of treating human cytomegalovirus, comprising the step of administering to a living subject in need of such treatment a therapeutically effective amount of:
a. a polypeptide consisting of the amino acid sequence disclosed in FIG. 2 of U.S. Pat. No. 5,559,212, or
b. a polypeptide consisting of the amino acid sequence of SEQ ID NO:2 of U.S. Pat. No. 5,728,805.
4. A method of treating roseolovirus-6B, comprising the step of administering to a living subject in need of such treatment a therapeutically effective amount of:
a. a polypeptide consisting of the amino acid sequence disclosed in FIG. 2 of U.S. Pat. No. 5,559,212, or
b. a polypeptide consisting of the amino acid sequence of SEQ ID NO:2 of U.S. Pat. No. 5,728,805.
5. A method of treating Epstein-Barr virus, comprising the step of administering to a living subject in need of such treatment a therapeutically effective amount of:
a. a polypeptide consisting of the amino acid sequence disclosed in FIG. 2 of U.S. Pat. No. 5,559,212, or
b. a polypeptide consisting of the amino acid sequence of SEQ ID NO:2 of U.S. Pat. No. 5,728,805.
6. A method of treating herpes simplex virus, comprising the step of administering to a living subject in need of such treatment a therapeutically effective amount of:
a. a polypeptide consisting of the amino acid sequence disclosed in FIG. 2 of U.S. Pat. No. 5,559,212, or
b. a polypeptide consisting of the amino acid sequence of SEQ ID NO:2 of U.S. Pat. No. 5,728,805.