IP Library › Granted Patent US 8,084,220
Granted Patent B2
US 8,084,220 · App. 12/955,398 · Granted Dec 27, 2011

Methods for detecting the presence of expanded CGG repeats in the FMR1 gene 5′ untranslated region

Assignee: The Regents of the University of California
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Quick Facts
Patent No.
US 8,084,220
App. No.
12/955,398
Granted
Dec 27, 2011
Kind
B2
Abstract

The invention provides improved methods for detecting the presence of expanded CGG repeats in the fragile X mental retardation 1 (FMR1) gene and for quantifying the amount of protein produced by the gene.

Claims (4)

1. A method of detecting the presence of fragile X mental retardation protein (FMRP) in a biological sample, said method comprising an enzyme-linked immunosorbent assay (ELISA) using a chicken IgY antibody as a capture antibody, said chicken IgY antibody specifically recognizing SEQ ID No: 3, wherein detecting binding of a detecting antibody to a polypeptide captured by said chicken IgY antibody in the biological sample indicates the presence of said FMRP in said sample.

2. A method of claim 1 , wherein said detecting antibody is a mouse anti-FMRP antibody.

3. A method of claim 1 , wherein said detecting is by detecting the presence of a luminescent substrate.

4. A method of claim 1 , wherein said detecting comprising quantifying the amount of said FMRP present in said sample.

Assignments (3)
CONFIRMATORY LICENSE Recorded Jul 6, 2011
From: UNIVERSITY OF CALIFORNIA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 026546/0010 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 11, 2011
From: HAGERMAN, PAUL J.; IWAHASHI, CHRISTINE K.
To: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Reel/Frame 025962/0372 →
CONFIRMATORY LICENSE Recorded Mar 1, 2011
From: UNIVERSITY OF CALIFORNIA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 025864/0241 →
Continuity (3)
Division 11779873 · Jul 18, 2007
Provisional Application 60832024 · Jul 19, 2006
Related Publication 20110207153A1 · Aug 25, 2011