Chemical compounds 572
View Patent ↗Compounds of formula (I): The present invention relates to novel indazolyl ester or amide derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments.
1. A compound
or a pharmaceutically acceptable salt thereof.
2. A mixture of N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(6-methoxypyridin-3-yl)propan-2-yl]cyclopropanecarboxamide, or a pharmaceutically acceptable salt thereof; and N-[(1S,2R)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(6-methoxypyridin-3-yl)propan-2-yl]cyclopropanecarboxamide, or a pharmaceutically acceptable salt thereof.
3. The mixture according to claim 2 , wherein the mixture is a racemic mixture.
4. N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(6-methoxypyridin-3-yl)propan-2-yl]cyclopropanecarboxamide, or a pharmaceutically acceptable salt thereof.
5. The compound according to claim 4 , which is N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(6-methoxypyridin-3-yl)propan-2-yl]cyclopropanecarboxamide.
6. The compound according to claim 4 , which is N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(6-methoxypyridin-3-yl)propan-2-yl]cyclopropanecarboxamide in the form of a pharmaceutically acceptable salt.
7. A pharmaceutical composition comprising a compound or a pharmaceutically acceptable salt thereof as claimed in claim 1 , and a pharmaceutically acceptable adjuvant, diluent or carrier.
8. A pharmaceutical composition comprising a mixture as claimed in claim 2 or 3 , and a pharmaceutically acceptable adjuvant, diluent or carrier.
9. A pharmaceutical composition comprising a compound or a pharmaceutically acceptable salt thereof as claimed in claim 4 , and a pharmaceutically acceptable adjuvant, diluent or carrier.
10. A pharmaceutical composition comprising a compound as claimed in claim 5 , and a pharmaceutically acceptable adjuvant, diluent or carrier.
11. A method of treating asthma, which comprises administering to a mammal that has asthma and is in need of treatment for asthma an effective amount of a compound or a pharmaceutically acceptable salt thereof as claimed in claim 1 .
12. A method of treating COPD, which comprises administering to a mammal that has COPD and is in need of treatment for COPD an effective amount of a compound or a pharmaceutically acceptable salt thereof as claimed in claim 1 .