IP Library Granted Patent US 8,470,382
Granted Patent B2
US 8,470,382 · App. 12/964,187 · Granted Jun 25, 2013

Carnitine granulate and methods for its production

Inventor: Thomas Büchner (Naters, CH)
Assignee: Lonza Ltd.
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 8,470,382
App. No.
12/964,187
Granted
Jun 25, 2013
Kind
B2
Abstract

Subject of the invention is a method for the production of a carnitine granulate, which includes the steps of (a) providing an aqueous solution comprising at least 65% (w/w) carnitine, (b) providing a particulate carrier comprising silica, the carrier having an average particle size of more than 150 μm, and (c) mixing the aqueous solution and the carrier. Another subject of the invention is a carnitine granulate.

Claims (21)

1. A method for the production of a carnitine granulate, comprising the steps of

(a) providing an aqueous solution comprising at least 65% (w/w) carnitine,

(b) providing a particulate carrier comprising silica, the carrier having an average particle size of more than 150 μm, and

(c) mixing the aqueous solution and the carrier,

wherein the temperature of the aqueous solution is above 60° C., and

whereby a drying step is excluded.

2. The method of claim 1 , wherein the viscosity of the carnitine solution in step (a) is between 0.5 to 150 mPas.

3. The method of claim 1 , wherein the average particle diameter of the carrier is between 150 and 500 μm.

4. The method of claim 1 , wherein the BET surface of the carrier is between 100 and 1000 m 2 /g.

5. The method of claim 1 , wherein in step (c) the aqueous solution is fed into a mixer containing the carrier whilst the mixer is agitated.

6. The method of claim 1 , wherein an anticaking agent is added.

7. The method of claim 1 , wherein the anticaking agent is hydrophobized silica particles.

8. The method of claim 5 , wherein in step (c) the aqueous solution is fed into the mixer during at least two time intervals, between which the feeding is interrupted whilst agitating the mixture.

9. The method of claim 1 , wherein step (c) comprises the steps of

(c1) feeding a first portion of the aqueous solution into the mixer,

(c2) agitating the mixture for at least 3 minutes whilst no aqueous solution is fed into the mixer,

(c3) feeding a second portion of the aqueous solution into the mixer,

(c4) agitating the mixture for at least 3 minutes whilst no aqueous solution is fed into the mixer,

wherein an anticaking agent is added during or after step (c3) or (c4),

wherein the mixer is agitated during steps (c1) to (c4).

10. The method of claim 1 , wherein the carnitine is L-carnitine.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 18, 2026
From: LONZA LTD, ALSO KNOWN AS LONZA AG
To: CAPSUGEL SWITZERLAND AG
Reel/Frame 073827/0097 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 22, 2011
From: BUCHNER, THOMAS
To: LONZA LTD
Reel/Frame 026168/0485 →
Priority Claims (1)
EP 09015339 · Dec 11, 2009 · regional
Continuity (2)
Provisional Application 61285805 · Dec 11, 2009
Related Publication 20110190394A1 · Aug 4, 2011