BMP-1 PROCOLLAGEN C-PROTEINASE FOR DIAGNOSIS AND TREATMENT OF BONE AND SOFT TISSUE DEFECTS AND DISORDERS
Uses of BMP-1 isoforms for diagnosing and treating defects and disorders of bone and soft tissues are described. Also described is a newly isolated variant of the BMP-1 isoform BMP-1-3.
1 . A method for diagnosing acute pancreatitis in an individual comprising: testing a blood sample from an individual to determine the presence in the sample of the BMP-1 isoform BMP-1-7, wherein the presence of said BMP-1 isoform in circulating blood of said individual is indicative of acute pancreatitis in the individual.
2 . A method for diagnosing chronic renal failure in an individual comprising: testing a blood sample from an individual to determine the presence in the sample of BMP-1 isoforms BMP-1-3 and BMP-1-5, wherein the presence of both said BMP-1 isoforms in circulating blood of said individual is indicative of chronic renal failure in said individual.
3 . A method of treating ischemic acute renal failure in an individual comprising administering a BMP-1 isoform systemically to the individual after diagnosis of renal injury.
4 . A method of treating ischemia/reperfusion damage to a kidney in an individual comprising: administering to the individual one or more antibody molecules specific for one or more BMP-1 isoforms in an amount effective to inhibit ischemia/reperfusion injury in said individual.
5 . The method according to claim 4 , wherein the one or more antibody molecules to one or more BMP-1 isoforms is administered systemically to the individual prior to an ischemia/reperfusion event.
6 . The method according to claim 4 , wherein an antibody molecule to BMP-1-1, an antibody molecule to BMP-1-3, or a combination of such antibody molecules is administered to the individual.