Nucleic acid encoding a T2R taste receptor
The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste transduction G-protein coupled receptors.
1. An isolated nucleic acid encoding a taste transduction G protein-coupled receptor having G protein-coupled receptor activity, the receptor comprising a polypeptide with greater than 95% amino acid sequence identity to SEQ ID NO:26, wherein said receptor detects bitter tastants.
2. The nucleic acid of claim 1 , wherein the polypeptide sequence is SEQ ID NO:26.
3. An isolated expression vector comprising the nucleic acid of claim 1 .
4. The isolated expression vector of claim 3 , wherein the polypeptide sequence is SEQ ID NO:26.
5. An isolated cell comprising the expression vector of claim 3 .
6. The isolated cell of claim 5 , wherein said polypeptide sequence is SEQ ID NO:26.