Substituted pyrimido isoquinoline derivatives
View Patent ↗Pyrimido isoquinoline derivatives represented by formula (I): wherein: R1, R2, R3, R4, R7, R8, R9, R10, and are as defined in the disclosure. Also disclosed are methods of preparing the compounds of formula (I) and their use in therapeutics.
1. A compound of formula (I):
wherein:
R1 represents a 4-pyridine ring or a 4-pyrimidine ring;
R2 represents a hydrogen atom;
R3 represents a hydrogen atom;
R4 represents a hydrogen atom or a halogen atom;
R7, R8, R9, R10 represent independently from each other a hydrogen atom, a halogen atom, a C 1-6 alkoxy group, a nitro, a hydroxyl or an amino; and
represents a single or a double bond, wherein when represents a single bond then there are hydrogen atoms attached to the carbon atoms adjacent to R3 and R4;
or an acid addition salt thereof.
2. The compound according to claim 1 of formula (I):
wherein:
R1 represents a 4-pyridine ring or a 4-pyrimidine ring;
R2 represents a hydrogen atom;
R3 represents a hydrogen atom;
R4 represents a hydrogen atom;
R7, R8, R9, R10 represent independently from each other a hydrogen atom, a halogen atom, a C 1-6 alkoxy group, a nitro, a hydroxyl or an amino; and
represents a single or a double bond, wherein when represents a single bond then there are hydrogen atoms attached to the carbon atoms adjacent to R3 and R4;
or an acid addition salt thereof.
3. The compound according to claim 1 selected from the group consisting of:
2-Pyridin-4-yl-pyrimido[2,1-a]isoquinolin-4-one;
10-Bromo-2-pyridin-4-yl-pyrimido[2,1-a]isoquinolin-4-one;
10-Methoxy-2-pyridin-4-yl-pyrimido[2,1-a]isoquinolin-4-one;
8-Nitro-2-pyridin-4-yl-pyrimido[2,1-a]isoquinolin-4-one;
8-Amino-2-pyridin-4-yl-pyrimido[2,1-a]isoquinolin-4-one;
10-Hydroxy-2-pyridin-4-yl-pyrimido[2,1-a]isoquinolin-4-one;
10-Methoxy-2-pyrimidin-4-yl-pyrimido[2,1-a]isoquinolin-4-one;
2-Pyridin-4-yl-6,7-dihydro-pyrimido[2,1-a]isoquinolin-4-one; and
9,10-Dimethoxy-2-pyridin-4-yl-6,7-dihydro-pyrimido[2,1-a]isoquinolin-4-one;
or an acid addition salt thereof.
4. A pharmaceutical composition comprising a compound of formula (I) according to claim 1 or a pharmaceutically acceptable salt thereof and one or more pharmaceutical additives.
5. A pharmaceutical composition comprising a compound of formula (I) according to claim 2 or a pharmaceutically acceptable salt thereof and one or more pharmaceutical additives.
6. A pharmaceutical composition comprising a compound according to claim 3 or a pharmaceutically acceptable salt thereof and one or more pharmaceutical additives.