Inhibition of the activity of the capsaicin receptor in the treatment of type 1 diabetes, type 2 diabetes, impaired glucose tolerance or insulin resistance
The present invention provides a method of treating diseases or disorders benefiting from inactivating or down-regulating the activity of the capsaicin receptor in a mammal by inhibiting the activity of the capsaicin receptor. The present invention also provides a method of treating obesity and obesity-related diseases and disorders in a mammal by inhibiting the activity of the capsaicin receptor.
1. A method for treating type 1 diabetes, type 2 diabetes, impaired glucose tolerance, or insulin resistance in a mammal comprising: administering to the mammal a therapeutically-effective amount of a direct capsaicin receptor antagonist.
2. The method according to claim 1 , wherein the method is for treating type 2 diabetes.
3. The method according to claim 1 , wherein the method is for treating type I diabetes.
4. The method according to claim 1 , wherein method is for treating impaired glucose tolerance.
5. The method according to claim 1 , wherein the direct capsaicin receptor antagonist is a natural product, synthetic organic compounds, peptide, protein, antibody, antibody fragment, single-chain antibody, or antibody-based construct.
6. The method according to claim 1 , wherein the mammal is human.
7. The method according to claim 1 , wherein the mammal is a domestic farm animal, a zoo animal, a sports animal, or companion animal.
8. The method according to claim 1 , wherein the antagonist is selected from the group consisting of diaryl piperazines, N-(3-acyloxy-2-benzylpropyl)-N-[4-(methylsulfonylamino)benzyl-thiourea; KJM429 [N-(4-tert-butylbenzyl)-N′-[4-(methylsulfonylamino)benzyl]thiourea]; JYL1421 [N-(4-tertbutylbenzyl)-N′-[3-fluoro-4-(methylsulfonylamino)benzyl]thiourea; N-(4-chlorobenzyl)-N′-(4-hydroxy-3-iodo-5-methoxybenzyl)thiourea (IBTU); acyclic phenethylthiocarbamate, N-(4-tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl) tetrahydropyrazine-1(2H)-carboxamide (BCTC), N-alkylglycines, 4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic acid (4-tert-butyl-phenyl)-amide, and (N-(3-methoxyphenyl)-4-chlorocinnamide (SB-366791).