Topical Uses of Szeto-Schiller Peptides
Provided are methods for improving the appearance aging or of peri-menopausal, menopausal, or post-menopausal skin comprising: applying to the skin tissue of a mammal in need of such regulation, a safe and effective amount of a composition comprising at least one Szeto-Schiller peptide and a dermatologically acceptable carrier. Compositions for use in the methods are also provided.
1 . A method of improving the appearance of peri-menopausal, menopausal, or post-menopausal skin comprising: applying to the skin tissue of a mammal in need of such regulation, a safe and effective amount of a composition comprising at least one Szeto-Schiller peptide selected from the group consisting of: Dmt-D-Arg-Phe-Lys-NH 2 (SEQ. ID. NO: 2), Phe-D-Arg-Phe-Lys-NH 2 (SEQ. ID. NO. 3) and D-Arg-Dmt-Lys-Phe-NH 2 (SEQ ID. NO: 4); and a dermatologically acceptable carrier.
2 . The method of claim 1 wherein the peptide is in the range from 0.1 ppm to 1000 ppm.
3 . The method of claim 2 wherein the peptide is the range from 1 ppm to 10 ppm.
4 . The method of claim 1 comprising up to 0.1% by weight of peptide.
5 . The method of claim 1 wherein the carrier comprises lecithin.
6 . The method of claim 1 wherein said composition further comprises one or more additional ingredients selected from the group consisting of: ascorbic acid and ascorbic acid derivatives; lipoic acid; α-hydroxy acids; and tocotrienols and tocotrienol derivatives and vitamin E compositions enriched with tocotrienols or tocotrienol derivatives.
7 . The method of claim 1 wherein severe skin dryness, dullness, or lack of radiance are improved.
8 . A method of preventing or retarding exaggerated lines and wrinkles of peri-menopausal, menopausal, or post-menopausal skin comprising: applying to the skin tissue of a mammal in need of such regulation, a safe and effective amount of a composition comprising at least one Szeto-Schiller peptide selected from the group consisting of: Dmt-D-Arg-Phe-Lys-NH 2 (SEQ. ID. NO: 2), Phe-D-Arg-Phe-Lys-NH 2 (SEQ. ID. NO. 3) and D-Arg-Dmt-Lys-Phe-NH 2 (SEQ ID. NO: 4); and a dermatologically acceptable carrier.
9 . The method of claim 8 wherein the peptide is in the range from 0.1 ppm to 1000 ppm.
10 . The method of claim 9 wherein the peptide is in the range from 1 ppm to 10 ppm.
11 . The method of claim 8 comprising up to 0.1% by weight of peptide.
12 . The method of claim 8 wherein the carrier comprises lecithin.
13 . The method of claim 8 wherein said composition further comprises one or more additional ingredients selected from the group consisting of: ascorbic acid and ascorbic acid derivatives; lipoic acid; α-hydroxy acids; and tocotrienols and tocotrienol derivatives and vitamin E compositions enriched with tocotrienols or tocotrienol derivatives.
14 . A method of preventing or retarding the appearance of spider vessels or red blotchiness in peri-menopausal, menopausal, or post-menopausal skin comprising: applying to the skin tissue of a mammal in need of such regulation, a safe and effective amount of a composition comprising at least one Szeto-Schiller peptide selected from the group consisting of: Dmt-D-Arg-Phe-Lys-NH 2 (SEQ. ID. NO: 2), Phe-D-Arg-Phe-Lys-NH 2 (SEQ. ID. NO. 3) and D-Arg-Dmt-Lys-Phe-NH 2 (SEQ ID. NO: 4); and a dermatologically acceptable carrier.
15 . The method of claim 14 wherein the peptide is in the range from 0.1 ppm to 1000 ppm.
16 . The method of claim 15 wherein the peptide is the range from 1 ppm to 10 ppm.
17 . The method of claim 14 comprising up to 0.1% by weight of peptide.
18 . The method of claim 14 wherein the carrier comprises lecithin.
19 . The method of claim 14 wherein said composition further comprises one or more additional ingredients selected from the group consisting of: ascorbic acid and ascorbic acid derivatives; lipoic acid; α-hydroxy acids; and tocotrienols and tocotrienol derivatives and vitamin E compositions enriched with tocotrienols or tocotrienol derivatives.
20 . A method of improving the appearance aging skin comprising: applying to the skin tissue of a mammal in need of such regulation, a safe and effective amount of a composition containing one or more peptides selected from the group consisting of Dmt-D-Arg-Phe-Lys-NH 2 (SEQ. ID. NO: 2), Phe-D-Arg-Phe-Lys-NH 2 (SEQ. ID. NO. 3) and D-Arg-Dmt-Lys-Phe-NH 2 (SEQ ID. NO: 4) in a dermatologically acceptable carrier.
21 . The method of claim 20 wherein the amount peptide is in the range from 0.1 ppm to 1000 ppm.
22 . The method of claim 21 wherein the amount of peptide is in the range from 1 ppm to 10 ppm.
23 . The method of claim 20 comprising no more than 0.1% by weight of peptide.
24 . The method of claim 20 wherein said composition further comprises one or more additional ingredients selected from the group consisting of: ascorbic acid and ascorbic acid derivatives; lipoic acid; α-hydroxy acids; and tocotrienols and tocotrienol derivatives and vitamin E compositions enriched with tocotrienols or tocotrienol derivatives.
25 . The method of claim 20 wherein skin dryness, dullness, or lack of radiance are improved.
26 . The method of claim 20 wherein exaggerated lines and wrinkles are prevented or retarded.
27 . The method of claim 20 wherein the appearance of spider vessels or red blotchiness is prevented or retarded.
28 . A topical composition to prevent and repair skin aging, comprising: an effective amount of at least one Szeto-Schiller peptide and a dermatologically acceptable carrier.
29 . The topical composition of claim 28 further comprising one or more additional ingredients selected from the group consisting of: ascorbic acid and ascorbic acid derivatives; lipoic acid; α-hydroxy acids; and tocotrienols and tocotrienol derivatives and vitamin E compositions enriched with tocotrienols or tocotrienol derivatives.
30 . The topical composition of claim 28 wherein the peptide is in the range from 0.1 ppm to 1000 ppm.
31 . The topical composition of claim 30 wherein the peptide is in the range from 50 to 500 ppm.
32 . The topical composition of claim 28 comprising up to 0.1% by weight of peptide.
33 . The topical composition of claim 28 wherein the carrier comprises lecithin.
34 . A method for the prevention and treatment of skin aging comprising: applying a composition containing Szeto-Schiller peptide selected from the group consisting of: Dmt-D-Arg-Phe-Lys-NH 2 (SEQ. ID. NO: 2), Phe-D-Arg-Phe-Lys-NH 2 (SEQ. ID. NO. 3) and D-Arg-Dmt-Lys-Phe-NH 2 (SEQ ID. NO: 4); and a dermatologically acceptable carrier to skin tissue.
35 . The method of claim 34 wherein the peptide is in the range from 0.1 ppm to 1000 ppm.
36 . The method of claim 35 wherein the peptide is in the range from 50 to 500 ppm.
37 . The method of claim 34 comprising up to 0.1% by weight peptide.
38 . The method of claim 34 wherein the carrier comprises lecithin.
39 . The method of claim 34 wherein said composition further comprises one or more additional ingredients selected from the group consisting of: ascorbic acid and ascorbic acid derivatives; lipoic acid; α-hydroxy acids; and tocotrienols and tocotrienol derivatives and vitamin E compositions enriched with tocotrienols or tocotrienol derivatives.