IP Library Granted Patent US 10,500,384
Granted Patent B2
US 10,500,384 · App. 12/986,812 · Granted Dec 10, 2019

Delivery system

Inventors: James J. Yoo (Winston-Salem, NC); Anthony Atala (Winston-Salem, NC); Kyle W. Binder (Winston-Salem, NC); Weixin Zhao (Winston-Salem, NC); Dennis Dice (Yadkinville, NC); Tao Xu (El Paso, TX)
Assignee: Wake Forest University Health Sciences
A61M35/00
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Quick Facts
Patent No.
US 10,500,384
App. No.
12/986,812
Granted
Dec 10, 2019
Kind
B2
Abstract

Provided herein is a delivery system, including: (a) an optical sensor configured to detect data useful to create a map of a bodily surface; and (b) a printer operatively associated with the optical sensor and configured to deliver compositions (optionally including cells) to the bodily surface based upon the data or map. Methods of forming a tissue on a bodily surface of a patient in need thereof are also provided, as are methods, systems and computer program products useful for processing bodily surface data.

Claims (24)

1. A system for processing data of a bodily surface obtained from a three-dimensional optical detector to provide a path to a printer operatively associated to said optical detector, said system comprising:

means for interpreting data from said optical detector to form a model of the bodily surface;

means for transforming said model into a negative mold of the bodily surface, which mold is split into a plurality of Z-axis layers; and

means for overlaying each of said layers of the negative mold with a series of lines which represents coverage of the bodily surface, wherein said lines provide a path for control software to use to control the printer to deliver cells and/or compositions to said bodily surface in situ based upon said bodily surface data,

wherein the bodily surface data is wound surface data, and

wherein said data is updated in real-time during delivery of the cells and/or compositions by said printer.

2. The system of claim 1 , further comprising means for obtaining the data.

3. The system of claim 1 , wherein the data is skin wound surface data, and wherein the Z-axis layers correspond to tissue layers comprising dermis and/or epidermis layers of skin tissue.

4. The system of claim 1 , wherein the data are represented as an object including the Z axis layers, and

wherein each of the Z axis layers are represented by a grid which comprises the series of lines.

5. The system of claim 4 , further comprising means for parsing the object in a manner that incorporates locations of different cells and/or compositions to be printed by the printer.

6. The system of claim 1 , wherein said Z-axis layers correspond to one or more tissue layers.

7. A computer program product for processing data of a bodily surface obtained from a three-dimensional optical detector to provide a path to a printer operatively associated to said optical detector, the computer program product comprising a non-transitory computer readable medium having computer readable program code embodied therein, the computer readable program code comprising:

computer readable program code which interprets the data of the bodily surface from said optical detector to form a model of the bodily surface;

computer readable program code which transforms said model into a negative mold of the bodily surface, which mold is split into a plurality of Z-axis layers; and

computer readable program code which overlays each of said Z-axis layers of the negative mold with a series of lines which represents coverage of the bodily surface, wherein said lines provide a path for control software to use to control the printer to deliver cells and/or compositions to said bodily surface in situ based upon said data,

wherein the bodily surface data is wound surface data,

wherein said data is updated in real-time during delivery of the cells and/or compositions by said printer,

wherein the data are represented as an object including the layers,

wherein each of the layers are represented by a grid which comprises the series of lines, and

wherein the computer readable program code is configured to direct the printer to deliver cells to a first location of the bodily surface associated with a first piece of the grid representing the object while analyzing a second piece of the grid.

8. The computer program product of claim 7 , further comprising computer readable program code which parses the object in a manner that incorporates locations of different cells and/or compositions to be printed by the printer.

9. The computer program product of claim 7 , wherein said Z-axis layers correspond to one or more tissue layers.

10. The computer program product of claim 9 , wherein said bodily surface is a skin wound surface, and wherein the tissue layers comprise dermis and/or layers of skin tissue epidermis layers of skin tissue.

Assignments (2)
CONFIRMATORY LICENSE Recorded Jul 7, 2011
From: WAKE FOREST UNIVERSITY HEALTH SCIENCES
To: US ARMY, SECRETARY OF THE ARMY
Reel/Frame 026558/0587 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 9, 2011
From: YOO, JAMES J.; ATALA, ANTHONY; BINDER, KYLE W.; ZHAO, WEIXIN; DICE, DENNIS; XU, TAO
To: WAKE FOREST UNIVERSITY HEALTH SCIENCES
Reel/Frame 025925/0045 →
Continuity (2)
Provisional Application 61293481 · Jan 8, 2010
Related Publication 20110172611A1 · Jul 14, 2011