Granted Patent
B2
US 8,916,532 · App. 12/989,758 · Granted Dec 23, 2014
Methods for enhancing utrophin production via inhibition of microRNA
Inventors:
Catherine Moorwood (Philadelphia, PA); Utpal Basu (Kolkata, IN); Gopal Patel (Roseville, CA); Olga Lozynska (Philadelphia, PA); Tejvir S. Khurana (Narnerth, PA)
View Patent ↗
Loading inventors, assignments & file history…
Abstract
This invention provides a method for enhancing utrophin protein production in a cell by inhibiting an utrophin microRNA molecule. Moreover, the invention provides that methods for enhancing utrophin protein production in a muscle cell are used for treating a muscular dystrophy and/or other myopathies.
Claims (1)
1. A method for treating Duchenne Muscular Dystrophy (DMD disease in a subject, comprising the step of administering to said subject a composition for inhibiting utrophin microRNA molecule, wherein said composition comprises a let-7c antisense molecule comprising the nucleic acid sequence set forth in SEQ ID NO: 2, thereby treating said DMD disease in said subject.
Assignments (2)
CONFIRMATORY LICENSE
Recorded Feb 13, 2015
From: UNIVERSITY OF PENNSYLVANIA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 034996/0103 →
CONFIRMATORY LICENSE
Recorded Jan 11, 2011
From: UNIVERSITY OF PENNSYLVANIA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 025615/0613 →
Continuity (2)
Provisional Application
61071408
· Apr 28, 2008