XBP1, CD138, and CS1 peptides
The disclosure features, inter alia, immunogenic XBP1-, CD138-, and CS1-derived peptides (and pharmaceutical compositions thereof). The peptides can be used in a variety of methods such as methods for inducing an immune response, methods for producing an antibody, and methods for treating a cancer (e.g., a plasma cell disorder such as multiple myeloma or Waldenstrom's macroglobulinemia). The peptides can also be included in MHC molecule multimer compositions and used in, e.g., methods for detecting a T cell in a population of cells.
1. A method for inducing an immune response in a subject having multiple myeloma, the method comprising administering to the subject a composition comprising:
(a) a CS-1 peptide consisting of the amino acid sequence of SEQ ID NO:16,
(b) an XBP-1 peptide consisting of the amino acid sequence of SEQ ID NO:6,
(c) an XBP-1 peptide consisting of the amino acid sequence of SEQ ID NO:10, and
(d) a CD138 peptide consisting of the amino acid sequence of SEQ ID NO:12.
2. The method of claim 1 , wherein the composition further comprises a pharmaceutically acceptable carrier.
3. The method of claim 2 , wherein the pharmaceutically acceptable carrier is one or more of a sterile diluent, an antibacterial agent, an antioxidant, a chelating agent, a buffer and an agent for the adjustment of tonicity.
4. The method of claim 3 , wherein the sterile diluent comprises one or more of water for injection, saline solution, fixed oils, polyethylene glycol, glycerine, propylene glycol and other synthetic solvents.
5. The method of claim 1 , wherein the composition further comprises one or more agents selected from therapeutic agents, diagnostic agents, prophylactic agents and immunostimulatory agents.
6. The method of claim 5 , wherein the composition comprises one or more immunostimulatory agents.
7. The method of claim 6 , wherein the one or more immunostimulatory agents comprises an adjuvant.
8. The method of claim 7 , wherein the adjuvant is one or more of Freund's incomplete adjuvant, alum, a ligand for a Toll receptor, QS21, RIBI, mutant cholera toxin (MCT), and mutant E. coli heat labile toxin (MLT).
9. The method of claim 8 , wherein the adjuvant comprises Freund's incomplete adjuvant.
10. The method of claim 8 , wherein the adjuvant comprises a ligand for a Toll receptor.
11. The method of claim 1 , wherein the subject is a human.