Granted Patent
B2
US 8,815,828 · App. 12/997,199 · Granted Aug 26, 2014
Therapeutic combinations for use in neoplasia
Inventors:
Satya Narayan (Gainesville, FL); Aruna S. Jaiswal (Gainesville, FL); David A. Ostrov (Gainesville, FL)
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Abstract
The invention features compositions and methods that are useful for the treatment of neoplasia (e.g., breast cancer) by increasing DNA damage and reducing base excision repair (BER).
Claims (2)
1. A kit for the treatment of breast cancer, the kit comprising temozolomide, O 6 -benzylguanine or curcumin and NSC-666715 (Benzosulfonamide, 4-chloro-N-[5-[(4-chlorophenyl)amino]1H-1,2,4-triazol-3-yl]-2-mercapto-5-methyl-(9Cl)), and directions for the use of the kit for the treatment of breast cancer.
2. A pharmaceutical composition for the treatment of breast cancer, the composition comprising temozolomide, O 6 -benzylguanine or curcumin, and NSC-666715 (Benzo sulfonamide, 4-chloro-N-[5-[(4-chlorophenyl)amino]1H-1,2,4-triazol-3-yl]-2-mercapto-5-methyl-(9Cl)).
Assignments (2)
CONFIRMATORY LICENSE
Recorded Nov 30, 2016
From: UNIVERSITY OF FLORIDA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 040785/0905 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Mar 24, 2011
From: NARAYAN, SATYA; JAISWAL, ARUNA S.; OSTROV, DAVID A.
To: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
Reel/Frame 026011/0378 →
Continuity (3)
Provisional Application
61133949
· Jul 2, 2008
Provisional Application
61113861
· Nov 12, 2008