IP Library › Granted Patent US 8,613,931
Granted Patent B2
US 8,613,931 · App. 12/997,674 · Granted Dec 24, 2013

Compounds for treating beta-amyloidoses

Inventors: Markus Mandler (Vienna, AT); Christian Gieffers (Dossenheim, DE); Frank Mattner (Vienna, AT); Andrea Dolischka (Vienna, AT); Oleksandr Otava (Vienna, AT)
Assignee: Affiris AG
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Quick Facts
Patent No.
US 8,613,931
App. No.
12/997,674
Granted
Dec 24, 2013
Kind
B2
Abstract

The present invention relates to the use of mimotopes in the treatment of diseases associated with β-amyloid formation and/or aggregation (β-Amyloidoses) including Alzheimer's disease, whereby said mimotopes are able to induce the in vivo formation of antibodies directed to Aβ1-40/42, AβpE3-40/42, Aβ3-40/42 and Aβ11-40/42.

Claims (15)

1. An isolated peptide consisting of 7 to 20 amino acid residues, wherein the isolated peptide comprises an amino acid sequence selected from the group consisting of IRWDTP(C) (SEQ ID NO: 106), VRWDVYP(C) (SEQ ID NO: 107), IRYDAPL(C) (SEQ ID NO: 108), IRYDMAG(C) (SEQ ID NO: 109), IRWDTSL(C) (SEQ ID NO: 110), IRWDQP(C) (SEQ ID NO: 111), IRWDG(C) (SEQ ID NO: 112), IRWDGG(C) (SEQ ID NO: 113), EVWHRHQ(C) (SEQ ID NO: 114), ERWHEKH(C) (SEQ ID NO: 115), EVWHRLQ(C) (SEQ ID NO: 116), ELWHRYP(C) (SEQ ID NO: 117), ELWHRAF(C) (SEQ ID NO: 118), ELWHRA(C) (SEQ ID NO: 119), EVWHRG(C) (SEQ ID NO: 120), EVWHRH(C) (SEQ ID NO: 121), ERWHEK(C) (SEQ ID NO: 122), QDFRHY(C) (SEQ ID NO: 123), SEFKHG(C) (SEQ ID NO: 124), TSFRHG(C) (SEQ ID NC): 125), TSVFRH(C) (SEQ ID NO: 126), TPFRHT(C) (SEQ ID NO: 127), SQFRHY(C) (SEQ ID NO: 128), LMFRHN(C) (SEQ ID NO: 129), SAFRHH(C) (SEQ ID NO: 130), LPFRHG(C) (SEQ ID NO: 131), SHFRHG(C) (SEQ ID NO: 132), ILFRHG(C) (SEQ ID NC): 133), QFKHDL(C) (SEQ ID NO: 134), NWFPHP(C) (SEQ ID NO: 135), EEFKYS(C) (SEQ ID NO: 136), NELRHST(C) (SEQ ID NO: 137), GEMRHQP(C) (SEQ ID NO: 138), DTYFPRS(C) (SEQ ID NO: 139), VELRHSR(C) (SEQ ID NO: 140), YSMRHDA(C) (SEQ ID NO: 141), AANYFPR(C) (SEQ ID NO: 142), SPNQFRH(C) (SEQ ID NO: 143), SSSFFPR(C) (SEQ ID NO: 144), EDWFFWH(C) (SEQ ID NO: 145), SAGSFRH(C) (SEQ ID NO: 146), QVMRHHA(C) (SEQ ID NO: 147), SEFSHSS(C) (SEQ ID NO: 148), QPNLFYH(C) (SEQ ID NO: 149), ELFKHHL(C) (SEQ ID NO: 150), TLHEFRH(C) (SEQ ID NO: 151), ATFRHSP(C) (SEQ ID NO: 152), APMYFPH(C) (SEQ ID NO: 153), TYFSHSL(C) (SEQ ID NO: 154), HEPLFSH(C) (SEQ ID NO: 155), SLMRHSS(C) (SEQ ID NO: 156), EFLRHTL(C) (SEQ ID NO: 157), ATPLFRH(C) (SEQ ID NO: 158), QELKRYY(C) (SEQ ID NO: 159), THTDFRH(C) (SEQ ID NO: 160), LHIPFRH(C) (SEQ ID NO: 161), NELFKHF(C) (SEQ ID NO: 162), SQYFPRP(C) (SEQ ID NO: 163), DEHPFRH(C) (SEQ ID NO: 164), MLPFRHG(C) (SEQ ID NO: 165), SAMRHSL(C) (SEQ ID NO: 166), TPLMFWH(C) (SEQ ID NO: 167), LQFKHST(C) (SEQ ID NO: 168), ATFRHST(C) (SEQ ID NO: 169), TGLMFKH(C) (SEQ ID NO: 170), AEFSHWH(C) (SEQ ID NO: 171), QSEFKHW(C) (SEQ ID NO: 172), AEFMHSV(C) (SEQ ID NO: 173), ADHDFRH(C) (SEQ ID NO: 174), DGLLFKH(C) (SEQ ID NO: 175), IGFRHDS(C) (SEQ ID NO: 176), SNSEFRR(C) (SEQ ID NO: 177), SELRHST(C) (SEQ ID NO: 178), THMEFRR(C) (SEQ ID NO: 179), EELRHSV(C) (SEQ ID NO: 180), QLFKHSP(C) (SEQ ID NO: 181), YEFRHAQ(C) (SEQ ID NO: 182), SNFRHSV(C) (SEQ ID NO: 183), APIQFRH(C) (SEQ ID NO: 184), AYFPHTS(C) (SEQ ID NO: 185), NSSELRH(C) (SEQ ID NO: 186), TEFRHKA(C) (SEQ ID NO: 187), TSTEMWH(C) (SEQ ID NO: 188), SQSYFKH(C) (SEQ ID NO: 189), (C)SEFKH (SEQ ID NO: 190), SEFKH(C) (SEQ ID NO: 191), (C)HEFRH (SEQ ID NO: 192) and HEFRH(C) (SEQ ID NO: 193).

2. A compound comprising the peptide of claim 1 coupled to a pharmaceutically acceptable carrier.

3. A pharmaceutical formulation comprising the peptide of claim 1 .

4. A vaccine comprising the peptide of claim 1 .

5. A process for treating β-amyloidoses, the process comprising administering to an individual a medicament comprising a compound comprising an amino acid sequence selected from the group consisting of EVWHRHQ(C) (SEQ ID NO: 114), ERWHEKH(C) (SEQ ID NO: 115), EVWHRLQ(C) (SEQ ID NO: 116), ELWHRYP(C) (SEQ ID NO: 117), ELWHRAF(C) (SEQ ID NO: 118), ELWHRA(C) (SEQ ID NO: 119), EVWHRG(C) (SEQ ID NO: 120), EVWHRH(C) (SEQ ID NO: 121), ERWHEK(C) (SEQ ID NO: 122), QDFRHY(C) (SEQ ID NO: 123), SEFKHG(C) (SEQ ID NO: 124), TSFRHG(C) (SEQ ID NO: 125), TSVFRH(C) (SEQ ID NO: 126), TPFRHT(C) (SEQ ID NO: 127), SQFRHY(C) (SEQ ID NO: 128), LMFRHN(C) (SEQ ID NO: 129), SAFRHH(C) (SEQ ID NO: 130), LPFRHG(C) (SEQ ID NO: 131), SHFRHG(C) (SEQ ID NO: 132), ILFRHG(C) (SEQ ID NO: 133), QFKHDL(C) (SEQ ID NO: 134), NWFPHP(C) (SEQ ID NO: 135), EEFKYS(C) (SEQ ID NO: 136), NELRHST(C) (SEQ ID NO: 137), GEMRHQP(C) (SEQ ID NO: 138), DTYFPRS(C) (SEQ ID NO: 139), VELRHSR(C) (SEQ ID NO: 140), YSMRHDA(C) (SEQ ID NO: 141), AANYFPR(C) (SEQ ID NO: 142), SPNQFRH(C) (SEQ ID NO: 143), SSSFFPR(C) (SEQ ID NO: 144), EDWFFWH(C) (SEQ ID NO: 145), SAGSFRH(C) (SEQ ID NO: 146), QVMRHHA(C) (SEQ ID NO: 147), SEFSHSS(C) (SEQ ID NO: 148), QPNLFYH(C) (SEQ ID NO: 149), ELFKHHL(C) (SEQ ID NO: 150), TLHEFRH(C) (SEQ ID NO: 151), ATFRHSP(C) (SEQ ID NO: 152), APMYFPH(C) (SEQ ID NO: 153), TYFSHSL(C) (SEQ ID NO: 154), HEPLFSH(C) (SEQ ID NO: 155), SLMRHSS(C) (SEQ ID NO: 156), EFLRHTL(C) (SEQ ID NO: 157), ATPLFRH(C) (SEQ ED NO: 158), QELKRYY(C) (SEQ ID NO: 159), THTDFRH(C) (SEQ ID NO: 160), LHIPFRH(C) (SEQ ID NO: 161), NELFKHF(C) (SEQ ID NO: 162), SQYFPRP(C) (SEQ ID NO: 163), DEHPFRH(C) (SEQ ID NO: 164), MLPFRHG(C) (SEQ ID NO: 165), SAMRHSL(C) (SEQ ID NO: 166), TPLMFWH(C) (SEQ ID NO: 167), LQFKHST(C) (SEQ ID NO: 168), ATFRHST(C) (SEQ ID NO: 169), TGLMFKH(C) (SEQ ID NO: 170), AEFSHWH(C) (SEQ ID NO: 171), QSEFKHW(C) (SEQ ID NO: 172), AEFMHSV(C) (SEQ ID NO: 173), ADHDFRH(C) (SEQ ID NO: 174), DGLLFKH(C) (SEQ ID NO: 175), IGFRHDS(C) (SEQ ID NO: 176), SNSEFRR(C) (SEQ ID NO: 177), SELRHST(C) (SEQ ID NO: 178), THMEFRR(C) (SEQ ID NO: 179), EELRHSV(C) (SEQ ID NO: 180), QLFKHSP(C) (SEQ ID NO: 181), YEFRHAQ(C) (SEQ ID NO: 182), SNFRHSV(C) (SEQ ED NO: 183), APIQFRH(C) (SEQ ID NO: 184), AYFPHTS(C) (SEQ ID NO: 185), NSSELRH(C) (SEQ ID NO: 186), TEFRHKA(C) (SEQ ID NO: 187), TSTEMWH(C) (SEQ ID NO: 188), SQSYFKH(C) (SEQ ID NO: 189), (C)SEFKH (SEQ ID NO: 190), SEFKH(C) (SEQ ID NO: 191), (C)HEFRH (SEQ ID NO: 192) and HEFRH(C) (SEQ ID NO: 193).

6. The process of claim 5 , wherein the compound comprises an amino acid sequence selected from the group consisting of QDFRHY(C) (SEQ ID NO: 123), SEFKHG(C) (SEQ ID NO: 124), TSFRHG(C) (SEQ ID NO: 125), TSVFRH(C) (SEQ ID NO: 126), TPFRHT(C) (SEQ ID NO: 127), SQFRHY(C) (SEQ ID NO: 128), LMFRHN(C) (SEQ ID NO: 129), SAFRHH(C) (SEQ ID NO: 130), LPFRHG(C) (SEQ ID NO: 131), SHFRHG(C) (SEQ ID NO: 132), ILFRHG(C) (SEQ ID NO: 133), QFKHDL(C) (SEQ ID NO: 134), NWFPHP(C) (SEQ ID NO: 135), EEFKYS(C) (SEQ ID NO: 136), SPNQFRH(C) (SEQ ID NO: 143), ELFKHHL(C) (SEQ ID NO: 150), TLHEFRH(C) (SEQ ID NO: 151), THTDFRH(C) (SEQ ID NO: 160), DEHPFRH(C) (SEQ ID NO: 164), QSEFKHW(C) (SEQ ID NO: 172), ADHDFRH(C) (SEQ ID NO: 174), DGLLFKH(C) (SEQ ID NO: 175), EELRHSV(C) (SEQ ID NO: 180), YEFRHAQ(C) (SEQ ID NO: 182), TEFRHKA(C) (SEQ ID NO: 187), (C)SEFKH (SEQ ID NO: 190), SEFKH(C) (SEQ ID NO: 191), (C)HEFRH (SEQ ID NO: 192) and HEFRH(C) (SEQ ID NO: 193).

7. The process of claim 5 , wherein the compound is a polypeptide consisting of 7 to 20 amino acid residues.

8. The process of claim 5 , wherein the compound is coupled to a pharmaceutically acceptable carrier.

9. The process of claim 8 , wherein the pharmaceutically acceptable carrier is KLH (Keyhole Limpet Hemocyanin).

10. The process of claim 5 , wherein the compound is formulated for intravenous, subcutaneous, intradermal or intramuscular administration.

11. The process of claim 5 , wherein the compound is formulated with an adjuvant.

12. The process of claim 11 , wherein the adjuvant is aluminium hydroxide.

13. The process of claim 5 , wherein the medicament comprises 0.1 ng to 10 mg of the compound.

14. The process of claim 5 , wherein the compound comprises an amino acid sequence selected from the group consisting of SEFKHG(C) (SEQ ID NO: 124), TLHEFRH(C) (SEQ ID NO: 151), ILFRHG(C) (SEQ ID NO: 133), TSVFRH(C) (SEQ ID NO: 126), SQFRHY(C) (SEQ ID NO: 128), LMFRHN(C) (SEQ ID NO: 129), SPNQFRH(C) (SEQ ID NO: 143), ELFKHHL(C) (SEQ ID NO: 150), THTDFRH(C) (SEQ ID NO: 160), DEHPFRH(C) (SEQ ID NO: 164), QSEFKHW(C) (SEQ ID NO: 172), ADHDFRH(C) (SEQ ID NO: 174), YEFRHAQ(C) (SEQ ID NO: 182) and TEFRHKA(C) (SEQ ID NO: 187).

15. The process of claim 5 , wherein the compound comprises an amino acid sequence selected from the group consisting of EVWHRHQ(C) (SEQ ID NO: 114), ERWHEKH(C) (SEQ ID NO: 115), EVWHRLQ(C) (SEQ ID NO: 116), ELWHRYP(C) (SEQ ID NO: 117), ELWHRAF(C) (SEQ ID NO: 118), ELWHRA(C) (SEQ ID NO: 119), EVWHRG(C) (SEQ ID NO: 120), EVWHRH(C) (SEQ ID NO: 121) and ERWHEK(C) (SEQ ID NO: 122).

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 17, 2011
From: MANDLER, MARKUS; GIEFFERS, CHRISTIAN; MATTNER, FRANK; DOLISCHKA, ANDREA; OTAVA, OLEKSANDR
To: AFFIRIS AG
Reel/Frame 025973/0886 →
Priority Claims (1)
AT A 951/2008 · Jun 12, 2008 · national
Continuity (1)
Related Publication 20110097351A1 · Apr 28, 2011