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1. A compound of the following formula:

wherein X is N or CH;

Y is N or CR 2 ;

Z is N or CR 3 ;

R 1 is aryl or heteroaryl, wherein said aryl and heteroaryl groups are optionally substituted on either the carbon or the heteroatom with one to three substituents independently selected from the group consisting of halo, hydroxyl, cyano, SO 2 R 4 , C 1-6 alkyl and heterocyclyl; wherein said alkyl group is optionally substituted with one to three halo, hydroxyl or cyano, and said heterocyclyl group is optionally substituted on either the carbon or heteroatom with one to three halo, hydroxyl or oxo;

R 2 is hydrogen, halo, cyano, C 1-6 alkyl, C 3-6 cycloalkyl, heteroaryl, heterocyclyl, (C═O)heterocyclyl, (C═O)R 4 , (C═O)OR 4 , (C═O)NR 4 R 5 , SO 2 R 4 , SO 2 NR 4 R 5 , NR 4 SO 2 R 5 or SO 2 (heterocyclyl); wherein said alkyl group is optionally substituted with one to three halo, hydroxyl, O(C═O)NR 4 R 5 , heteroaryl, heterocyclyl or NR 4 R 5 ; said heterocyclyl groups are optionally substituted on either the carbon or heteroatom with one to two groups independently selected from the group consisting of C 1-3 alkyl, hydroxyl and oxo; and said heteroaryl groups are optionally substituted on either the carbon or heteroatom with C 1-6 alkyl;

R 3 is hydrogen or C 1-6 alkyl, wherein said alkyl group is optionally substituted with one to three halo or hydroxyl;

R 4 is hydrogen or C 1-6 alkyl;

R 5 is hydrogen or C 1-6 alkyl;

or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 wherein R 1 is aryl, wherein said aryl group is substituted with one to three substituents independently selected from the group consisting of halo and C 1-6 alkyl, wherein said alkyl group is optionally substituted with hydroxyl; or a pharmaceutically acceptable salt thereof.

3. The compound of claim 2 wherein R 1 is phenyl, wherein said phenyl group is substituted with one to three substituents independently selected from the group consisting of halo and C 1-6 alkyl, wherein said alkyl group is optionally substituted with hydroxyl; or a pharmaceutically acceptable salt thereof.

4. The compound of claim 1 wherein X is CH; Y is CR 2 ; Z is CR 3 ; or a pharmaceutically acceptable salt thereof.

5. The compound of claim 4 wherein R 2 is C 1-6 alkyl, heterocyclyl, (C═O)heterocyclyl or (C═O)NR 4 R 5 ; wherein said alkyl group is optionally substituted with one to three halo, hydroxyl, O(C═O)NR 4 R 5 , heteroaryl, heterocyclyl or NR 4 R 5 ; said heterocyclyl groups are optionally substituted on either the carbon or heteroatom with one to two groups independently selected from the group consisting of hydroxyl or oxo; or a pharmaceutically acceptable salt thereof.

6. The compound of claim 5 wherein R 2 is C 1-3 alkyl, (C═O)heterocyclyl or (C═O)NR 4 R 5 ; wherein said alkyl group is optionally substituted with heterocyclyl or NR 4 R 5 ; said heterocyclyl groups are optionally substituted on either the carbon or heteroatom with one to two groups independently selected from the group consisting of hydroxyl or oxo; or a pharmaceutically acceptable salt thereof.

7. The compound of claim 1 selected from

5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[4-(methylsulfonyl)phenyl]amino}thiophene-3-carboxamide;

5-(4-chlorophenyl)-2-{[4-(methylsulfonyl)phenyl]amino}thiophene-3-carboxamide;

2-{[4-(methylsulfonyl)phenyl]amino}-5-(6-morpholin-4-ylpyridin-3-yl)thiophene-3-carboxamide;

5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({4-[(methylamino)carbonyl]phenyl}amino)thiophene-3-carboxamide;

5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({4-[(dimethylamino)carbonyl]phenyl}amino)thiophene-3-carboxamide;

5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-(pyridin-4-ylamino)thiophene-3-carboxamide;

5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[2-(hydroxymethyl)pyridin-4-yl]amino}thiophene-3-carboxamide;

2-[(4-cyanophenyl)amino]-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide;

5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[4-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]amino}thiophene-3-carboxamide;

2-[(4-acetylphenyl)amino]-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide;

5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[4-(1-hydroxy-1-methylethyl)phenyl]amino}thiophene-3-carboxamide;

Methyl 4-({3-(aminocarbonyl)-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-thienyl}amino)benzoate;

ethyl 4-({3-(aminocarbonyl)-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-thienyl}amino)benzoate;

5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}thiophene-3-carboxamide;

2-Anilino-5-phenylthiophene-3-carboxamide;

5-Phenyl-2-(pyridin-3-ylamino)thiophene-3-carboxamide;

5-Phenyl-2-(pyrimidin-5-ylamino)thiophene-3-carboxamide;

5-Phenyl-2-(pyridin-4-ylamino)thiophene-3-carboxamide;

2-anilino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide;

5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[4-(hydroxymethyl)phenyl]amino}thiophene-3-carboxamide;

5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[4-(morpholin-4-ylmethyl)phenyl]amino}thiophene-3-carboxamide;

5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({4-[(1,1-dioxidothiomorpholin-4-yl)methyl]phenyl}amino)thiophene-3-carboxamide;

5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({4-[(dimethylamino)methyl]phenyl}amino)thiophene-3-carboxamide;

5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[4-(pyrrolidin-1-ylmethyl)phenyl]amino}thiophene-3-carboxamide;

5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[4-(morpholin-4-ylsulfonyl)phenyl]amino}thiophene-3-carboxamide;

5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({4-[(dimethylamino)sulfonyl]phenyl}amino)thiophene-3-carboxamide;

5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({4-[(1,1-dioxidothiomorpholin-4-yl)sulfonyl]phenyl}amino)thiophene-3-carboxamide;

5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({4-[(methylsulfonyl)amino]phenyl}amino)thiophene-3-carboxamide;

5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({4-[(methylsulfonyl)amino]phenyl}amino)thiophene-3-carboxamide;

2-({4-[(1,1-dioxidothiomorpholin-4-yl)methyl]phenyl}amino)-5-[4-(methyl sulfonyl)phenyl]thiophene-3-carboxamide;

Methyl [4-({3-(aminocarbonyl)-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-thienyl}amino)benzyl]carbamate;

5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[4-(2H-1,2,3-triazole-2-ylmethyl)phenyl]amino}thiophene-3-carboxamide;

5-(4-(1-Hydroxy-1-methylethyl)phenyl)-2-(3-pyridinylamino)-3-thiophenecarboxamide;

5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)-phenyl]-2-({4-[(4-methylpiperazin-1-yl)carbonyl]-phenyl}amino)-thiophene-3-carboxamide;

5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({4-[(1,1-dioxidothiomorpholin-4-yl)carbonyl]phenyl}amino)thiophene-3-carboxamide;

5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-[(4-formylphenyl)amino]thiophene-3-carboxamide;

or a pharmaceutically acceptable salt thereof.

8. A pharmaceutical composition comprising a pharmaceutically effective amount of the compound according to claim 1 , and a pharmaceutically acceptable carrier.