Oxazolopyrimidines as Edg-1 receptor agonists
View Patent ↗The present invention relates to oxazolopyrimidine compounds of the formula I in which A, R 1 , R 2 and R 3 are defined as indicated in the claims. The compounds of the formula I modulate the activity of the Edg-1 receptor and in particular are agonists of this receptor, and are useful for the treatment of diseases such as atherosclerosis, heart failure or peripheral arterial occlusive disease, for example. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.
1. A compound selected from any of the following compounds:
2-(3-fluoro-phenyl)-5-morpholin-4-ylmethyl-7-propoxy-oxazolo[5,4-d]pyrimidine,
3-(5-morpholin-4-ylmethyl-7-propoxy-oxazolo[5,4-d]pyrimidin-2-yl)-phenol,
2-(2-chloro-5-fluoro-phenyl)-5-[1,4]oxazepan-4-ylmethyl-7-propoxy-oxazolo[5,4-d]pyrimidine,
2-(2-chloro-pyridin-4-yl)-5-morpholin-4-ylmethyl-7-propoxy-oxazolo[5,4-d]pyrimidine,
5-cyclohexylmethyl-7-propoxy-2-m-tolyl-oxazolo[5,4-d]pyrimidine,
5-(1-phenyl-ethyl)-7-propoxy-2-m-tolyl-oxazolo[5,4-d]pyrimidine,
3-{4-[5-(4-chloro-benzyl)-7-propoxy-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-propane-1,2-diol,
1-{4-[5-(4-chloro-benzyl)-7-ethoxy-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-3-diethylamino-propan-2-ol,
1-{4-[5-(4-chloro-benzyl)-7-ethoxy-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-3-morpholin-4-yl-propan-2-ol,
1-hydroxy-cyclopropanecarboxylic acid (3-{4-[5-(4-chloro-benzyl)-7-ethoxy-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-2-hydroxy-propyl)-amide,
N-(3-{4-[5-(4-chloro-benzyl)-7-propoxy-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-2-hydroxy-propyl)-acetamide,
4-{4-[5-(4-chloro-benzyl)-7-propoxy-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-butyric acid,
(2-{4-[5-(4-chloro-benzyl)-7-propoxy-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetylamino)-acetic acid,
3-(3-{4-[5-(4-chloro-benzyl)-7-propoxy-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-2-hydroxy-propylamino)-propionic acid,
(S)-1-(2-{4-[5-(4-chloro-benzyl)-7-propoxy-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetyl)-pyrrolidine-2-carboxylic acid,
1-(5-tert-butyl-4H-[1,2,4]triazole-3-sulfonyl)-3-{4-[5-(4-chloro-benzyl)-7-ethoxy-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-propan-2-ol, and
4-[5-(4-chloro-benzyl)-7-ethoxy-oxazolo[5,4-d]pyrimidin-2-yl]-2-fluoro-phenol,
including any stereoisomeric forms, any mixture of stereoisomeric forms in any ratio, or a physiologically acceptable salt thereof, or a physiologically acceptable solvate of any of them.
2. A pharmaceutical composition, comprising at least one compound of as claimed in claim 1 , or a physiologically acceptable salt thereof, or a physiologically acceptable solvate of any of them, and a pharmaceutically acceptable carrier.