Acetates of 2-deoxy monosaccharides with anticancer activity

1. A method reducing, mitigating, or ameliorating cancer in a patient in need thereof comprising the step of administering to said patient a therapeutically effective amount of one or more compounds of the Formula I:

or a salt thereof, wherein

R 1 , R 2 , R 3 , and R 4 are each independently H, COCH 3 , COCH 2 CH 3 , or COCH 2 CH 2 CH 3 ;

and R 5 and R 6 are each independently H or F ( 18 F or 19 F);

wherein at least one of R 1 , R 2 , R 3 , and R 4 is COCH 3 or COCH 2 CH 3 .

2. A method of inhibiting glycolysis in a patient in need thereof comprising the step of administering to said patient a therapeutically effective amount of one or more compounds of the Formula I:

or a salt thereof, wherein R 1 , R 2 , R 3 , and R 4 are each independently H, COCH 3 , COCH 2 CH 3 , or

COCH 2 CH 2 CH 3 ;

and R 5 and R 6 are each independently H or F ( 18 F or 19 F);

wherein at least one of R 1 , R 2 , R 3 , and R 4 is COCH 3 or COCH 2 CH 3 .

3. A compound of the structural formula:

4. A compound of the structural formula:

5. A compound of the structural formula:

6. A compound of the structural formula:

7. A compound of the structural formula:

8. A compound of the structural formula: