Glycopeptide constructs and uses thereof
Glycopeptide conjugates, and methods of making and using such conjugates are disclosed. Certain glycopeptide conjugates comprise tumor associated carbohydrate antigens and peptide epitopes. Certain glycopeptide conjugates comprise cyclic peptide scaffolds that display carbohydrate antigens in a clustered fashion. The immunogenicity of select glycopeptide conjugates is demonstrated.
1. A multi-antigenic construct having the structure (SEQ ID NO: 24)
2. A pharmaceutical composition comprising a therapeutically effective amount of a construct of claim 1 and at least one pharmaceutically acceptable carrier or excipient.
3. A construct having the structure of:
4. A pharmaceutical composition comprising a therapeutically effective amount of a construct of claim 3 and at least one pharmaceutically acceptable carrier.