4-phenoxy-nicotinamide or 4-phenoxy-pyrimidine-5-carboxamide compounds

1. A compound of formula I,

wherein

A 1 is CR 13 ;

A 2 is CR 14 ;

R 1 and R 2 are independently from each other selected from the group consisting of hydrogen, C 1-7 -alkyl, halogen, halogen-C 1-7 -alkyl, cyano and C 1-7 -alkoxy;

R 13 and R 14 are independently from each other selected from the group consisting of hydrogen, halogen, halogen-C 1-7 -alkyl, and C 1-7 -alkoxy;

R 3 and R 4 together are —NR 21 (CR 17 R 18 ) 2 — and form part of a ring; wherein

R 17 and R 18 are independently from each other hydrogen or methyl;

R 21 is selected from the group consisting of hydrogen, C 1-7 -alkyl, C 3-7 -cycloalkyl optionally substituted by carboxyl-C 1-7 -alkyl or C 1-7 -alkoxycarbonyl, C 3-7 -cycloalkyl-C 1-7 -alkyl wherein the C 3-7 -cycloalkyl is optionally substituted by carboxyl-C 1-7 -alkyl or C 1-7 -alkoxycarbonyl, and C 1-7 -alkylsulfonyl,

B 1 is N or N + —O − ;

B 2 is CR 7 or N;

R 5 , R 6 and R 7 independently from each other are selected from the group consisting of hydrogen, halogen, C 1-7 -alkyl, C 1-7 -alkoxy, halogen-C 1-7 -alkyl, halogen-C 1-7 -alkoxy, and cyano;

and R 8 , R 9 , R 10 , R 11 and R 12 are independently from each other selected from the group consisting of hydrogen, C 1-7 -alkyl, C 2-7 -alkenyl, C 2-7 -alkinyl, halogen, halogen-C 1-7 -alkyl, C 1-7 -alkoxy, halogen-C 1-7 -alkoxy, hydroxy, hydroxy-C 1-7 -alkoxy, hydroxy-C 1-7 -alkyl, hydroxy-C 3-7 -alkenyl, hydroxy-C 3-7 -alkinyl, cyano, carboxyl, C 1-7 -alkoxycarbonyl, aminocarbonyl, carboxyl-C 1-7 -alkyl, carboxyl-C 2-7 -alkenyl, carboxyl-C 2-7 -alkinyl, C 1-7 -alkoxycarbonyl-C 1-7 -alkyl, C 1-7 -alkoxycarbonyl-C 2-7 -alkenyl, C 1-7 -alkoxycarbonyl-C 2-7 -alkinyl, carboxyl-C 1-7 -alkoxy, C 1-7 -alkoxycarbonyl-C 1-7 -alkoxy, carboxyl-C 1-7 -alkyl-aminocarbonyl, carboxyl-C 1-7 -alkyl-(C 1-7 -alkylamino)-carbonyl, C 1-7 -alkoxycarbonyl-C 1-7 -alkyl-aminocarbonyl, C 1-7 -alkoxycarbonyl-C 1-7 -alkyl-(C 1-7 -alkylamino)-carbonyl, carboxyl-C 1-7 -alkyl-aminocarbonyl-C 1-7 -alkyl, carboxyl-C 1-7 -alkyl-(C 1-7 -alkylamino)-carbonyl-C 1-7 -alkyl, C 1-7 -alkoxycarbonyl-C 1-7 -alkyl-aminocarbonyl-C 1-7 -alkyl, C 1-7 -alkoxycarbonyl-C 1-7 -alkyl-(C 1-7 -alkylamino)-carbonyl-C 1-7 -alkyl, hydroxy-C 1-7 -alkyl-aminocarbonyl, di-(hydroxy-C 1-7 -alkyl)aminocarbonyl, aminocarbonyl-C 1-7 -alkyl-aminocarbonyl, hydroxysulfonyl-C 1-7 -alkyl-aminocarbonyl, hydroxysulfonyl-C 1-7 -alkyl-(C 1-7 -alkyl-amino)-carbonyl, di-(C 1-7 -alkoxycarbonyl-C 1-7 -alkyl)-methylaminocarbonyl, phenyl optionally substituted by one to three groups selected from halogen, C 1-7 -alkoxy, carboxyl or C 1-7 -alkoxycarbonyl, phenyl-carbonyl wherein the phenyl is optionally substituted by one to three groups selected from halogen, C 1-7 -alkoxy, carboxyl and C 1-7 -alkoxycarbonyl, phenyl-aminocarbonyl wherein the phenyl is optionally substituted by one to three groups selected from halogen, C 1-7 -alkoxy, carboxyl and C 1-7 -alkoxycarbonyl, phenyl-C 1-7 -alkyl wherein the phenyl is optionally substituted by one to three groups selected from halogen, C 1-7 -alkoxy, carboxyl and C 1-7 -alkoxycarbonyl, phenyl-C 2-7 -alkinyl wherein the phenyl is optionally substituted by one to three groups selected from halogen, C 1-7 -alkoxy, carboxyl and C 1-7 -alkoxycarbonyl,

heteroaryl optionally substituted by one to three groups selected from halogen, C 1-7 -alkoxy, carboxyl and C 1-7 -alkoxycarbonyl, heteroaryl-carbonyl wherein the heteroaryl is optionally substituted by one to three groups selected from halogen, C 1-7 -alkoxy, carboxyl and C 1-7 -alkoxycarbonyl, heteroaryl-aminocarbonyl wherein the heteroaryl is optionally substituted by one to three groups selected from halogen, C 1-7 -alkoxy, carboxyl and C 1-7 -alkoxycarbonyl, heteroaryl-C 1-7 -alkyl wherein the heteroaryl is optionally substituted by one to three groups selected from halogen, C 1-7 -alkyl, C 1-7 -alkoxy, carboxyl and C 1-7 -alkoxycarbonyl, heteroaryl-C 1-7 -alkyl-aminocarbonyl wherein the heteroaryl is optionally substituted by one to three groups selected from halogen, C 1-7 -alkoxy, carboxyl and C 1-7 -alkoxycarbonyl, and heteroaryl-carbonyl-C 1-7 -alkyl wherein the heteroaryl is optionally substituted by one to three groups selected from halogen, C 1-7 -alkoxy, carboxyl and C 1-7 -alkoxycarbonyl;

or a pharmaceutically acceptable salt thereof.

2. A compound according to claim 1 , wherein R 1 and R 2 are independently from each other selected from the group consisting of hydrogen, halogen and halogen-C 1-7 -alkyl.

3. A compound according to claim 1 , wherein B 1 is N or N + —O − and B 2 is CR 7 , with R 7 being selected from the group consisting of hydrogen, halogen and C 1-7 -alkyl.

4. A compound according to claim 1 , wherein B 1 is N and B 2 is N.

5. A compound according to claim 1 , wherein R 5 and R 6 are independently from each other selected from the group consisting of hydrogen, halogen and C 1-7 -alkyl.

6. A compound according to claim 1 , wherein at least two of R 8 , R 9 , R 10 , R 11 and R 12 are selected from the group consisting of

C 1-7 -alkyl, C 2-7 -alkenyl, C 2-7 -alkinyl, halogen, halogen-C 1-7 -alkyl, C 1-7 -alkoxy, halogen-C alkoxy, hydroxy, hydroxy-C 1-7 -alkoxy, hydroxy-C 1-7 -alkyl, hydroxy-C 3-7 -alkenyl, hydroxy-C 3-7 -alkinyl, cyano, carboxyl, C 1-7 -alkoxycarbonyl, aminocarbonyl, carboxyl-C 1-7 -alkyl, carboxyl-C 2-7 -alkenyl, carboxyl-C 2-7 -alkinyl, C 1-7 -alkoxycarbonyl-C 1-7 -alkyl, C 1-7 -alkoxycarbonyl-C 2-7 -alkenyl, C 1-7 -alkoxycarbonyl-C 2-7 -alkinyl, carboxyl-C 1-7 -alkoxy, C 1-7 -alkoxycarbonyl-C 1-7 -alkoxy, carboxyl-C 1-7 -alkyl-aminocarbonyl, carboxyl-C 1-7 -alkyl-(C 1-7 -alkylamino)-carbonyl, C 1-7 -alkoxycarbonyl-C 1-7 -alkyl-aminocarbonyl, C 1-7 -alkoxycarbonyl-C 1-7 -alkyl-(C 1-7 -alkylamino)-carbonyl, carboxyl-C 1-7 -alkyl-aminocarbonyl-C 1-7 -alkyl, carboxyl-C 1-7 -alkyl-(C 1-7 -alkylamino)-carbonyl-C 1-7 -alkyl, C 1-7 -alkoxycarbonyl-C 1-7 -alkyl-aminocarbonyl-C 1-7 -alkyl, C 1-7 -alkoxycarbonyl-C 1-7 -alkyl-(C 1-7 -alkylamino)-carbonyl-C 1-7 -alkyl, hydroxy-C 1-7 -alkyl-aminocarbonyl, di-(hydroxy-C 1-7 -alkyl)aminocarbonyl, aminocarbonyl-C 1-7 -alkyl-aminocarbonyl, hydroxysulfonyl-C 1-7 -alkyl-aminocarbonyl, hydroxysulfonyl-C 1-7 -alkyl-(C 1-7 -alkyl-amino)-carbonyl, di-(C 1-7 -alkoxycarbonyl-C 1-7 -alkyl)-methylaminocarbonyl, phenyl optionally substituted by one to three groups selected from halogen, C 1-7 -alkoxy, carboxyl and C 1-7 -alkoxycarbonyl, phenyl-carbonyl wherein the phenyl is optionally substituted by one to three groups selected from halogen, C 1-7 -alkoxy, carboxyl and C 1-7 -alkoxycarbonyl, phenyl-aminocarbonyl wherein the phenyl is optionally substituted by one to three groups selected from halogen, C 1-7 -alkoxy, carboxyl and C 1-7 -alkoxycarbonyl, phenyl-C 1-7 -alkyl wherein the phenyl is optionally substituted by one to three groups selected from halogen, C 1-7 -alkoxy, carboxyl and C 1-7 -alkoxycarbonyl, phenyl-C 2-7 -alkinyl wherein the phenyl is optionally substituted by one to three groups selected from halogen, C 1-7 -alkoxy, carboxyl and C 1-7 -alkoxycarbonyl, heteroaryl optionally substituted by one to three groups selected from halogen, C 1-7 -alkoxy, carboxyl and C 1-7 -alkoxycarbonyl, heteroaryl-carbonyl wherein the heteroaryl is optionally substituted by one to three groups selected from halogen, C 1-7 -alkoxy, carboxyl and C 1-7 -alkoxycarbonyl, heteroaryl-aminocarbonyl wherein the heteroaryl is optionally substituted by one to three groups selected from halogen, C 1-7 -alkoxy, carboxyl and C 1-7 -alkoxycarbonyl, heteroaryl-C 1-7 -alkyl wherein the heteroaryl is optionally substituted by one to three groups selected from halogen, C 1-7 -alkyl, C 1-7 -alkoxy, carboxyl and C 1-7 -alkoxycarbonyl, heteroaryl-C 1-7 -alkyl-aminocarbonyl wherein the heteroaryl is optionally substituted by one to three groups selected from halogen, C 1-7 -alkoxy, carboxyl and C 1-7 -alkoxycarbonyl, and heteroaryl-carbonyl-C 1-7 -alkyl wherein the heteroaryl is optionally substituted by one to three groups selected from halogen, C 1-7 -alkoxy, carboxyl and C 1-7 -alkoxycarbonyl,

and the other ones of R 8 , R 9 , R 10 , R 11 and R 12 are hydrogen.

7. A compound according to claim 1 , wherein at least two of R 8 , R 9 , R 10 , R 11 and R 12 are selected from the group consisting of

halogen, hydroxy, hydroxy-C 1-7 -alkoxy, hydroxy-C 1-7 -alkyl, cyano, carboxyl, C 1-7 -alkoxycarbonyl, aminocarbonyl, carboxyl-C 1-7 -alkoxy, C 1-7 -alkoxycarbonyl-C 1-7 -alkoxy, carboxyl-C 1-7 -alkyl-aminocarbonyl, carboxyl-C 1-7 -alkyl-(C 1-7 -alkylamino)-carbonyl, C 1-7 -alkoxycarbonyl-C 1-7 -alkyl-aminocarbonyl, hydroxy-C 1-7 -alkyl-aminocarbonyl, di-(hydroxy-C 1-7 -alkyl)aminocarbonyl, aminocarbonyl-C 1-7 -alkyl-aminocarbonyl, hydroxysulfonyl-C 1-7 -alkyl-aminocarbonyl, hydroxysulfonyl-C 1-7 -alkyl-(C 1-7 -alkyl-amino)-carbonyl, di-(C 1-7 -alkoxycarbonyl-C 1-7 -alkyl)-methylaminocarbonyl, phenyl-aminocarbonyl wherein the phenyl is optionally substituted by one to three groups selected from halogen, C 1-7 -alkoxy, carboxyl and C 1-7 -alkoxycarbonyl, heteroaryl-aminocarbonyl wherein the heteroaryl is optionally substituted by one to three groups selected from halogen, C 1-7 -alkoxy, carboxyl and C 1-7 -alkoxycarbonyl, heteroaryl-C 1-7 -alkyl wherein the heteroaryl is optionally substituted by one to three groups selected from halogen, C 1-7 -alkyl, C 1-7 -alkoxy, carboxyl and C 1-7 -alkoxycarbonyl, heteroaryl-C 1-7 -alkyl-aminocarbonyl wherein the heteroaryl is optionally substituted by one to three groups selected from halogen, C 1-7 -alkoxy, carboxyl and C 1-7 -alkoxycarbonyl, and heteroaryl-carbonyl-C 1-7 -alkyl wherein the heteroaryl is optionally substituted by one to three groups selected from halogen, C 1-7 -alkoxy, carboxyl and C 1-7 -alkoxycarbonyl,

and the other ones of R 8 , R 9 , R 10 , R 11 and R 12 are hydrogen.

8. A compound according to claim 1 , wherein R 8 and R 11 are halogen and R 9 , R 10 and R 12 are hydrogen.

9. A compound according to claim 1 , selected from the group consisting of

[4-(2,5-dichloro-phenoxy)-pyridin-3-yl]-(3,4-dihydro-2H-quinoxalin-1-yl)-methanone,

[4-(2,5-dichloro-phenoxy)-pyridin-3-yl]-(4-methyl-3,4-dihydro-2H-quinoxalin-1-yl)-methanone,

2-{4-[4-(2,5-dichloro-phenoxy)-pyridine-3-carbonyl]-3,4-dihydro-2H-quinoxalin-1-ylmethyl}-cyclopropanecarboxylic acid ethyl ester,

(4-cyclopropylmethyl-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-phenoxy)-pyridin-3-yl]-methanone,

[4-(2,5-dichloro-phenoxy)-pyridin-3-yl]-(4-methanesulfonyl-3,4-dihydro-2H-quinoxalin-1-yl)-methanone,

(4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-phenoxy)-pyridin-3-yl]-methanone,

(6-chloro-4-cyclopropyl-7-fluoro-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-phenoxy)-pyridin-3-yl]-methanone,

(6-chloro-4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-phenoxy)-pyridin-3-yl]-methanone,

and pharmaceutically-acceptable salts thereof.

10. A compound according to claim 1 , selected from the group consisting of

[4-(4-bromo-2,5-dichloro-phenoxy)-pyridin-3-yl]-(4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-methanone,

2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzoic acid methyl ester,

4-chloro-5-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-phthalic acid dimethyl ester,

{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzoylamino}-acetic acid methyl ester,

{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzoylamino}-acetic acid,

({2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzoyl}-methyl-amino)-acetic acid methyl ester,

({2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzoyl}-methyl-amino)-acetic acid,

3-{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzoylamino}-propionic acid ethyl ester,

and pharmaceutically-acceptable salts thereof.

11. A compound according to claim 1 , selected from the group consisting of

3-{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzoylamino}-propionic acid,

2-{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzoylamino}-ethanesulfonic acid,

2-({2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzoyl}-methyl-amino)-ethanesulfonic acid,

3-{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzoylamino}-propane-1-sulfonic acid,

and pharmaceutically-acceptable salts thereof.

12. A compound selected from the group consisting of

[4-(2,5-dichloro-phenoxy)-pyridin-3-yl]-(4-methyl-3,4-dihydro-2H-quinoxalin-1-yl)-methanone,

(4-cyclopropylmethyl-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-phenoxy)-pyridin-3-yl]-methanone,

(4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-phenoxy)-pyridin-3-yl]-methanone,

(6-chloro-4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-phenoxy)-pyridin-3-yl]-methanone,

[4-(4-bromo-2,5-dichloro-phenoxy)-pyridin-3-yl]-(4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-methanone,

{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzoylamino}-acetic acid,

3-{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzoylamino}-propionic acid,

2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-N-(1H-tetrazol-5-yl)-benzamide,

2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-N-(1H-tetrazol-5-ylmethyl)-benzamide,

4-{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzoylamino}-1-methyl-1H-pyrrole-2-carboxylic acid,

4-{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzoylamino}-benzoic acid,

2-{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzoylamino}-4-methyl-thiazole-5-carboxylic acid,

2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzonitrile,

(4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-phenoxy)-6-methyl-pyridin-3-yl]-methanone,

3-{2,5-dichloro-4-[5-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-2-methyl-pyridin-4-yloxy]-benzoylamino}-propionic acid,

2,5-dichloro-4-[5-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-2-methyl-pyridin-4-yloxy]-N-(1H-tetrazol-5-yl)-benzamide,

(4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-phenoxy)-1-oxy-pyridin-3-yl]-methanone,

[4-(2,5-dichloro-phenoxy)-pyrimidin-5-yl]-(4-methyl-3,4-dihydro-2H-quinoxalin-1-yl)-methanone,

and pharmaceutically acceptable salts thereof.

13. A pharmaceutical composition comprising a compound according to claim 1 and a pharmaceutically acceptable carrier and/or adjuvant.

14. A compound selected from the group consisting of

2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-N-(1H-tetrazol-5-yl)-benzamide,

2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-N-(1H-tetrazol-5-ylmethyl)-benzamide,

4-{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzoylamino}-butyric acid,

4-{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzoylamino}-1-methyl-1H-pyrrole-2-carboxylic acid methyl ester,

4-{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzoylamino}-1-methyl-1H-pyrrole-2-carboxylic acid,

4-{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzoylamino}-benzoic acid methyl ester,

4-{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzoylamino}-benzoic acid,

2-{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzoylamino}-4-methyl-thiazole-5-carboxylic acid ethyl ester,

2-{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzoylamino}-4-methyl-thiazole-5-carboxylic acid,

5-{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzoylamino}-[1,3,4]thiadiazole-2-carboxylic acid ethyl ester,

2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-N-[1,3,4]thiadiazol-2-yl-benzamide,

2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-N-(2-hydroxy-ethyl)-benzamide,

2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-N,N-bis-(2-hydroxy-ethyl)-benzamide,

2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-N-(2-hydroxy-1-hydroxymethyl-ethyl)-benzamide,

2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzamide,

and pharmaceutically acceptable salts thereof.

15. A compound according to claim 1 , selected from the group consisting of

N-(2-carbamoyl-ethyl)-2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzamide,

4-{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzoylamino}-heptanedioic acid dimethyl ester,

(4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-4-hydroxymethyl-phenoxy)-pyridin-3-yl]-methanone,

2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzonitrile,

(4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-4-hydroxy-phenoxy)-pyridin-3-yl]-methanone,

{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-phenoxy}-acetic acid ethyl ester,

{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-phenoxy}-acetic acid,

2-{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-phenoxy}-2-methyl-propionic acid ethyl ester,

2-{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-phenoxy}-2-methyl-propionic acid,

(4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-{4-[2,5-dichloro-4-(2-hydroxy-ethoxy)-phenoxy]-pyridin-3-yl}-methanone,

(4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-phenoxy)-6-methyl-pyridin-3-yl]-methanone,

[4-(4-bromo-2,5-dichloro-phenoxy)-6-methyl-pyridin-3-yl]-(4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-methanone,

2,5-dichloro-4-[5-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-2-methyl-pyridin-4-yloxy]-benzoic acid methyl ester,

2,5-dichloro-4-[5-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-2-methyl-pyridin-4-yloxy]-benzoic acid,

3-{2,5-dichloro-4-[5-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-2-methyl-pyridin-4-yloxy]-benzoylamino}-propionic acid ethyl ester,

and pharmaceutically acceptable salts thereof.

16. A compound according to claim 1 , selected from the group consisting of

3-{2,5-dichloro-4-[5-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-2-methyl-pyridin-4-yloxy]-benzoylamino}-propionic acid,

{2,5-dichloro-4-[5-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-2-methyl-pyridin-4-yloxy]-benzoylamino}-acetic acid methyl ester,

{2,5-dichloro-4-[5-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-2-methyl-pyridin-4-yloxy]-benzoylamino}-acetic acid,

2,5-dichloro-4-[5-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-2-methyl-pyridin-4-yloxy]-N-(1H-tetrazol-5-yl)-benzamide,

2,5-dichloro-4-[5-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-2-methyl-pyridin-4-yloxy]-N-(1H-tetrazol-5-ylmethyl)-benzamide,

[2-chloro-4-(2,5-dichloro-phenoxy)-6-methyl-pyridin-3-yl]-(4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-methanone,

(4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-phenoxy)-1-oxy-pyridin-3-yl]-methanone,

[4-(2,5-dichloro-phenoxy)-pyrimidin-5-yl]-(3,4-dihydro-2H-quinoxalin-1-yl)-methanone,

[4-(2,5-dichloro-phenoxy)-pyrimidin-5-yl]-(4-methyl-3,4-dihydro-2H-quinoxalin-1-yl)-methanone,

and pharmaceutically acceptable salts thereof.