IP Library Granted Patent US 8,428,687
Granted Patent B2
US 8,428,687 · App. 13/019,029 · Granted Apr 23, 2013

Systems and methods for matching and imaging tissue characteristics

Inventors: Elisa Konofagou (New York, NY); Jean Provost (New York, NY)
Assignee: The Trustees of Columbia University in the City of New York
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Quick Facts
Patent No.
US 8,428,687
App. No.
13/019,029
Granted
Apr 23, 2013
Kind
B2
Abstract

Systems and methods for matching a characteristic of multiple sectors of a moving tissue to verify an overlap thereof are disclosed herein. In an exemplary method, tissue data for at least a first sector and a second sector of a moving tissue is acquired. A characteristic of at least a portion of the first and second sectors is estimated from the acquired tissue data, and the estimated characteristics are matched to verify whether a portion of the first sector overlaps with a portion of the second sector. Estimating can include estimating a displacement such as an axial displacement and/or lateral displacements. Estimating can further include estimating a strain, a velocity, a strain rate and/or a stiffness or equivalent.

Claims (35)

1. A method for matching a characteristic of two or more sectors of a moving tissue to verify whether any portions thereof overlap, comprising:

acquiring tissue data for at least a first sector and a second sector of said moving tissue;

estimating, using a processing arrangement, a characteristic of at least a portion of said first sector and a characteristic of at least a portion of said second sector from said acquired tissue data; and

matching, using a processing arrangement, said estimated characteristic of said portion of said first sector with said estimated characteristic of said portion of said second sector, to verify whether said portion of said first sector overlaps with said portion of said second sector; and

determining a time delay between said matched characteristic of said portion of said first sector and said matched characteristic of said portion of said second sector.

2. The method of claim 1 , further comprising forming an image of said matched characteristic of said portion of said first sector and said matched characteristic of said portion of said second sector utilizing said determined time delay.

3. The method of claim 2 , wherein forming said image comprises forming a one-dimensional image of said tissue.

4. The method of claim 2 , wherein forming said image comprises forming a two-dimensional image of said tissue.

5. The method of claim 2 , wherein forming said image comprises forming a three-dimensional image of said tissue.

6. The method of claim 2 , wherein forming said image comprises forming a four-dimensional image of said tissue.

7. The method of claim 1 , wherein estimating said characteristic further comprises estimating a displacement.

8. The method of claim 7 , wherein said displacement comprises axial displacement.

9. The method of claim 7 , wherein said displacement comprises lateral displacement.

10. The method of claim 1 , wherein estimating said characteristic further comprises estimating a strain.

11. The method of claim 1 , wherein estimating said characteristic further comprises estimating a velocity.

12. The method of claim 1 , wherein estimating said characteristic further comprises estimating a strain rate.

13. The method of claim 1 , wherein estimating said characteristic further comprises estimating a stiffness.

14. The method of claim 1 , wherein estimating said characteristic further comprises using a speckle-tracking technique.

15. The method of claim 1 , further comprising:

acquiring electrical activity data from said moving tissue; and

determining a correspondence between said electrical activity and said estimated characteristic of said portion of said first sector and said estimated characteristic of said portion of said second sector.

16. A system for matching a characteristic of two or more sectors of a moving tissue to verify whether any portions thereof overlap, comprising:

a computer readable medium storing program instructions; and

a processor adapted to receive tissue data for at least a first sector and a second sector of said moving tissue, wherein said processor is operatively connected to said computer readable medium and configured to execute said stored program instructions, wherein said processor is further configured such that upon execution of said stored program instructions, said processor:

estimates a characteristic of at least a portion of said first sector and a characteristic of at least a portion of said second sector from said acquired tissue data, and

matches said estimated characteristic of said portion of said first sector with said estimated characteristic of said portion of said second sector, to verify whether said portion of said first sector overlaps with said portion of said second sector, and wherein said processor is further configured to determine a time delay between said matched characteristic of said portion of said first sector and said matched characteristic of said portion of said second sector.

17. The system of claim 16 , wherein said processor is further configured to form an image of said matched characteristic of said portion of said first sector and said matched characteristic of said portion of said second sector utilizing said determined time delay.

18. The system of claim 16 , further comprising a data acquisition device for acquiring data from two or more sectors of said tissue.

19. The system of claim 18 , wherein said data acquisition device comprises an ultrasound device.

20. The system of claim 18 , wherein said data acquisition device comprises an MRI device.

21. The system of claim 18 , wherein said data acquisition device comprises a CT device.

22. The system of claim 18 , wherein said data acquisition device is capable of acquiring data at a rate of at least 50 frames per second.

23. The system of claim 18 , wherein said data acquisition device is capable of acquiring data at a rate of up to 10000 frames per second.

24. The system of claim 16 , further comprising an electrical detection device configured to detect an electrical signal propagating through said tissue.

25. The system of claim 24 , wherein said electrical detection device comprises an electrocardiographic device.

Assignments (2)
CONFIRMATORY LICENSE Recorded Aug 23, 2011
From: COLUMBIA UNIV NEW YORK MORNINGSIDE
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 026789/0157 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 5, 2011
From: KONOFAGOU, ELISA; PROVOST, JEAN
To: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
Reel/Frame 026231/0708 →
Continuity (5)
Continuation In Part PCTUS2009052563 · Aug 3, 2009
Provisional Application 61108470 · Oct 24, 2008
Provisional Application 61086112 · Aug 4, 2008
Provisional Application 61085709 · Aug 1, 2008
Related Publication 20110208038A1 · Aug 25, 2011