Methods of treating cancer by administering antibodies to CD200
Methods and compositions for regulating immunity are disclosed. For enhancing an immune response, agents that inhibit OX-2 are administered. Such methods are useful in treating cancer. For suppressing an immune response, an OX-2 protein or a nucleic acid encoding an OX-2 protein is administered. Such methods are useful in preventing graft rejection, fetal loss, autoimmune disease, allergies and in inducing tumor cell growth.
1. A method of stimulating type-1 cytokine production comprising administering an effective amount of an antibody that binds and inhibits a CD200 protein to a cell or animal in need thereof.
2. The method according to claim 1 for enhancing an immune response.
3. The method according to claim 1 for treating cancer.
4. The method according to claim 3 wherein the cancer is leukemia.
5. A method according to claim 4 further comprising administering a chemotherapeutic agent.
6. The method according to claim 1 wherein the antibody is a monoclonal antibody.
7. A method according to claim 6 wherein the antibody comprises a humanized antibody.
8. A method according to claim 6 wherein the antibody comprises an Fv, scFv, Fab′ or F(ab′)2 fragment.