Modulation of bacterial quorum sensing with synthetic ligands
The present invention provides compounds and methods for modulation of the quorum sensing of bacteria. In an embodiment, the compounds of the present invention are able to act as replacements for naturally occurring bacterial quorum sensing ligands in a ligand-protein binding system; that is, they imitate the effect of natural ligands and produce an agonistic effect. In another embodiment, the compounds of the present invention are able to act in a manner which disturbs or inhibits the naturally occurring ligand-protein binding system in quorum sensing bacteria; that is, they produce an antagonistic effect. The compounds of the present invention comprise N-acylated-homoserine lactones (AHLs) comprised of a wide range of acyl groups.
1. A compound represented by the formula FX1:
or a pharmaceutically acceptable salt or ester thereof,
wherein m is 1;
each R1, R2, and R3 is hydrogen;
X is —O—;
Y is
L is —(CH 2 ) p —, wherein p is selected from the range of 1 to 15;
Z is selected from the group consisting of:
n is 0; and
A is selected from the group consisting of:
2. The compound of claim 1 wherein p is 1 or 2.