Pyridine derivatives and their use in the treatment of psychotic disorders

1. A method of treatment of anxiety disorders which comprises administering to a host in need thereof an effective amount of a compound of formula (I):

wherein:

X represents a nitrogen atom;

Y represents (—C(H 2 )—) 2 ;

Z represents an oxygen atom;

A represents hydrogen or —CH 2 OH;

R z represents hydrogen, C 1-6 alkyl, C 1-6 alkoxy, —COR 7 or —SO 2 R 7 ;

R 1 represents halogen, C 1-6 alkyl, C 1-6 alkoxy, ═O, haloC 1-6 alkyl, haloC 1-6 alkoxy, hydroxyl or —CH 2 OH;

m represents an integer from 0 to 3;

R 2 represents halogen, ═O, C 1-6 alkyl (optionally substituted by one or more hydroxyl groups), —COOR 7 , —CONR 7 R 8 , C 1-6 alkoxy, haloC 1-6 alkyl, haloC 1-6 alkoxy or C 1-6 alkylOC 1-6 alkyl,

n represents an integer from 0 to 3;

p and q independently represent 1;

R 3 represents an -aryl, -heteroaryl, -heterocyclyl, -aryl-aryl, -aryl-heteroaryl, -aryl-heterocyclyl, -heteroaryl-aryl, -heteroaryl-heteroaryl, -heteroaryl-heterocyclyl, -heterocyclyl-aryl, -heterocyclyl-heteroaryl or -heterocyclyl-heterocyclyl group, all of which may be optionally substituted by one or more (e.g. 1, 2 or 3) halogen, C 1-6 alkyl (optionally substituted by one or more hydroxyl groups), C 3-8 cycloalkyl, C 1-6 alkoxy, hydroxyl, haloC 1-6 alkyl, haloC 1-6 alkoxy, cyano, —S—C 1-6 alkyl, —SO—C 1-6 alkyl, —SO 2 —C 1-6 alkyl, —COR 7 , —CONR 7 R 8 , —NR 7 R 8 , —NR 7 COC 1-6 alkyl, —NR 7 SO 2 —C 1-6 alkyl, C 1-6 alkyl-NR 7 R 8 , —OCONR 7 R 8 , —NR 7 CO 2 R 8 or —SO 2 NR 7 R 8 groups;

R 4 and R 5 independently represent C 1-6 alkyl, or R 4 and R 5 together with the carbon atom to which they are attached may together form a C 3-8 cycloalkyl group;

R 6 represents halogen, C 1-6 alkyl, C 3-8 cycloalkyl, C 1-6 alkoxy, haloC 1-6 alkyl or haloC 1-6 alkoxy;

s represents an integer from 0 to 4;

R 7 and R 8 independently represent hydrogen, C 1-6 alkyl or C 3-8 cycloalkyl;

or a pharmaceutically acceptable salt or solvate thereof.

2. The method of claim 1 , wherein the anxiety disorder is post traumatic stress disorder.

3. The method of claim 1 , wherein R 3 represents -aryl mono substituted by a halogen or C 1-6 alkyl group, -aryl di substituted by a halogen and C 1-6 alkyl group, -aryl monosubstituted by C 1-6 alkyl substituted by one or more hydroxyl groups, -aryl di substituted by a halogen, -heteroaryl monosubstituted by C 1-6 alkyl or -heteroaryl di substituted by a halogen and a C 1-6 alkyl group.

4. The method of claim 3 , wherein the anxiety disorder is post traumatic stress disorder.

5. A method of treatment of anxiety disorders which comprises administering to a host in need thereof an effective amount of a compound of formula:

or a pharmaceutically acceptable salt thereof.

6. The method of claim 5 , wherein the anxiety disorder is post traumatic stress disorder.