Analgesic compounds, compositions, and uses thereof
The invention relates to compounds, compositions, and methods for diminishing pain in a subject in need thereof comprising administering the compounds and compositions herein described.
1. A compound according to Formula I or a salt thereof:
wherein in Formula I:
R 1 and R 2 are independently hydrogen or alkyl, or R 1 and R 2 form together a radical according to the formula (CH 2 ) n , wherein n is selected from the group consisting of 2, 3, 4, 5 and 6;
R 3 is, independently at each occurrence, hydrogen, alkyl, substituted alkyl, alkenyl, alkynyl, halogen, phenyl, substituted phenyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, hydroxyl, alkoxy, cyano, nitro, acyl, carboxy, carboxyalkyl, or amido;
R 4 is hydrogen, alkyl, substituted alkyl, or acyl; and
W is carboxy, or carboxyalkyl.
2. The compound of claim 1 , wherein R 1 and R 2 are CH 3 .
3. A compound selected from the group consisting of (S)-2-(2-hydroxyphenylamino)-thiazoline-5,5-dimethyl-4-carboxylic acid, (R)-2-(2-hydroxyphenylamino)-thiazoline-5,5-dimethyl-4-carboxylic acid, (R)-2-(2-Hydroxy-4-methoxyphenylamino)-thiazoline-4-carboxylic acid, (R)-2-(4-Fluoro-2-hydroxyphenylamino)-thiazoline-4-carboxylic acid, (R)-2-(3,5-Dichloro-2-hydroxy-4-methylphenylamino)-thiazoline-4-carboxylic acid, (R)-2-(5-tert-Butyl-2-hydroxyphenylamino)-thiazoline-4-carboxylic acid, (R)-2-(2-Hydroxy-4-methoxycarbonylphenylamino)-thiazoline-4-carboxylic acid, (R)-2-(5-Ethanesulfonyl-2-hydroxy-phenylamino)-thiazoline-4-carboxylic acid, (R)-2-(4-Chloro-2-hydroxyphenylamino)-thiazoline-4-carboxylic acid, (R)-2-(2-Hydroxy-5-methoxyphenylamino)-thiazoline-4-carboxylic acid, (S)-2-(2-Hydroxy-5-chlorophenylamino)-thiazoline-5,5-dimethyl-4-carboxylic acid methyl ester, (S)-2-(2-Hydroxy-5-chlorophenylamino)-thiazoline-5,5-dimethyl-4-carboxylic acid, (S)-2-(2-Hydroxy-5-methylphenylamino)-thiazoline-5,5-dimethyl-4-carboxylic acid methyl ester, (S)-2-(2-Hydroxy-5-methylphenylamino)-thiazoline-5,5-dimethyl-4-carboxylic acid, (S)-2-(2-Hydroxy-4-methoxyphenylamino)-thiazoline-5,5-dimethyl-4-carboxylic acid, (S)-2-(2-Hydroxy-4-methoxyphenylamino)-thiazoline-5,5-dimethyl-4-carboxylic acid methyl ester, (S)-2-(4-Chloro-2-hydroxyphenylamino)-thiazoline-5,5-dimethyl-4-carboxylic acid, (S)-2-(2-Hydroxy-5-nitrophenylamino)-thiazoline-5,5-dimethyl-4-carboxylic acid methyl ester, (S)-2-(2-Hydroxy-5-nitrophenylamino)-thiazoline-5,5-dimethyl-4-carboxylic acid, (S)-2-(5-Ethanesulfonyl-2-hydroxyphenylamino)-thiazoline-5,5-dimethyl-4-carboxylic acid methyl ester, (S)-2-(5-Ethanesulfonyl-2-hydroxyphenylamino)-thiazoline-5,5-dimethyl-4-carboxylic acid, (R)-2-(2-hydroxyphenylamino)-thiazoline-4-carboxylic acid methyl ester, (S)-2-(2-hydroxyphenylamino)-thiazoline-5,5-dimethyl-4-carboxylic acid methyl ester, (R)-2-(4-chloro-2-hydroxyphenylamino)-thiazoline-4-carboxylic acid methyl ester, (S)-2-(4-chloro-2-hydroxyphenylamino)-thiazoline-5,5-dimethyl-4-carboxylic acid methyl ester, (R)-2-(4-chloro-2-hydroxyphenylamino)-thiazoline-4-carboxylic acid, and (R)-2-(2-hydroxyphenylamino)-thiazoline-5,5-dimethyl-4-carboxylic acid methyl ester, mixtures thereof and salts thereof.