Use of 5,6-dimethylxanthenone-4-acetic acid as an antiviral agent
The invention relates to the areas of therapeutics, pharmaceuticals, drug discovery, and immunotherapy. More specifically, the present invention relates to methods of stimulating the immune system through the administration of flavone acetic acid [FAA] analogs, and in particular, the flavone acetic acid analog, 5,6-dimethylxanthenone-4-acetic acid (DMXAA) so as to comprise an antimicrobial therapeutic agent for the treatment of viral infections of DNA and RNA viruses in humans and non-human animals. The invention is especially suitable for use in a process of treating and preventing infection by, for example, rhinoviruses, enteroviruses, and influenza viruses.
1. A method for treating a viral pathogen infection in a mammal comprising administering to the mammal in need of such treatment a pharmaceutical composition comprising DMXAA (5,6-dimethylxanthenone-4-acetic acid) or
a pharmaceutically acceptable salt or ester thereof with a pharmaceutically acceptable acid; and
(B) one or more pharmaceutically acceptable carriers, diluents or excipients;
wherein the administered pharmaceutical composition is provided in a therapeutic amount sufficient to induce expression of IFN-β thereby providing an IFN-β-mediated anti-viral response, wherein the viral pathogen is an influenza virus.
2. The method of claim 1 , wherein said virus infects respiratory tract, and said administration of said composition is to the respiratory system of said recipient mammal.
3. The method of claim 1 , wherein DMXAA is administered in conjunction with a second compound, said second compound being a therapeutic agent.
4. A method of treating a mammal who has already been exposed to a viral pathogen comprising administering to the mammal in need of such treatment a pharmaceutical composition comprising DMXAA (5,6-dimethylxanthenone-4-acetic acid) or a pharmaceutically acceptable salt or ester thereof with a pharmaceutically acceptable acid; and
one or more pharmaceutical acceptable carriers, diluents or excipients;
wherein the administered pharmaceutical composition is provided in a prophylactic amount sufficient to induce expression of IFN-β thereby providing an IFN-β-mediated anti-viral response; and
wherein the viral pathogen is an influenza virus.
5. The method of claim 4 , wherein said virus infects respiratory tract, and said administration of said composition is to the respiratory system of said recipient mammal.
6. The method of claim 4 , wherein the mammal is selected from the group consisting of young children, immunocompromised individuals, travelers, military personnel, healthcare workers, and the elderly.
7. A method of treating a mammal who is at risk of infection by a viral pathogen comprising administering to the mammal in need of such treatment a pharmaceutical composition comprising DMXAA (5,6-dimethylxanthenone-4-acetic acid) or a pharmaceutically acceptable salt or ester thereof with a pharmaceutically acceptable acid;
and one or more pharmaceutically acceptable diluents or excipients;
wherein the administered pharmaceutical composition is provided in a prophylactic amount sufficient to induce expression of IFN-β thereby providing an IFN-β-mediated anti-viral response; and
wherein the viral pathogen is an influenza virus, and
wherein the mammal is selected from the group consisting of young children, travelers, military personnel, healthcare workers, and elderly.