COMBINATIONS FOR THE TREATMENT OF IMMUNOINFLAMMATORY DISORDERS
The invention features pharmaceutical compositions that include dipyridamole and a corticosteroid.
1 . A method of reducing the levels of TNFα in mammalian blood, comprising contacting cells in the blood with a composition consisting of a corticosteroid, dipyridamole, and excipients.
2 . The method of claim 1 , wherein the method suppresses the secretion of TNFα.
3 . The method of claim 1 , wherein the cells have been stimulated to secrete TNFα.
4 . The method of claim 3 wherein the cells comprise white blood cells.
5 . The method of claim 1 , further comprising the step of confirming the reduction in TNFα levels.
6 . The method of claim 5 , wherein the confirming step comprises the use of an antibody or an antibody-based assay.
7 . The method of claim 6 wherein the antibody-based assay is an ELISA.
8 . The method of claim 1 , wherein said corticosteroid is algestone, 6-alpha-fluoroprednisolone, 6-alpha-methylprednisolone, 6-alpha-methylprednisolone 21-acetate, 6-alpha-methylprednisolone 21-hemisuccinate sodium salt, 6-alpha,9-alpha-difluoroprednisolone 21-acetate 17-butyrate, amcinafal, beclomethasone, beclomethasone dipropionate, beclomethasone dipropionate monohydrate, 6-beta-hydroxycortisol, betamethasone, betamethasone-17-valerate, budesonide, clobetasol, clobetasol propionate, clobetasone, clocortolone, clocortolone pivalate, cortisone, cortisone acetate, cortodoxone, deflazacort, 21-deoxycortisol, deprodone, descinolone, desonide, desoximethasone, dexamethasone, dexamethasone-21-acetate, dichlorisone, diflorasone, diflorasone diacetate, diflucortolone, doxibetasol, fludrocortisone, flumethasone, flumethasone pivalate, flumoxonide, flunisolide, fluocinonide, fluocinolone acetonide, 9-fluorocortisone, fluorohydroxyandrostenedione, fluorometholone, fluorometholone acetate, fluoxymesterone, flupredidene, fluprednisolone, flurandrenolide, formocortal, halcinonide, halometasone, halopredone, hyrcanoside, hydrocortisone, hydrocortisone acetate, hydrocortisone butyrate, hydrocortisone cypionate, hydrocortisone sodium phosphate, hydrocortisone sodium succinate, hydrocortisone probutate, hydrocortisone valerate, 6-hydroxydexamethasone, isoflupredone, isoflupredone acetate, isoprednidene, meclorisone, methylprednisolone, methylprednisolone acetate, methylprednisolone sodium succinate, paramethasone, paramethasone acetate, prednisolone, prednisolone acetate, prednisolone metasulphobenzoate, prednisolone sodium phosphate, prednisolone tebutate, prednisolone-21-hemisuccinate free acid, prednisolone-21-acetate, prednisolone-21(beta-D-glucuronide), prednisone, prednylidene, procinonide, tralonide, triamcinolone, triamcinolone acetonide, triamcinolone acetonide 21-palmitate, triamcinolone diacetate, or triamcinolone hexacetonide.
9 . The method of claim 8 , wherein said corticosteroid is prednisone or prednisolone.
10 . The method of claim 9 , wherein said composition comprises 0.5 to 10 mg of prednisone or prednisolone.
11 . The method of claim 9 , wherein said composition comprises 100 to 400 mg of dipyridamole.
12 . The method of claim 1 , wherein said composition comprises 100 to 400 mg of dipyridamole.
13 . The method of claim 1 , wherein said composition comprises 0.5 to 10 mg corticosteroid.
14 . The method of claim 13 , wherein said composition comprises 0.5 to 10 mg corticosteroid and 100 to 400 mg of dipyridamole.